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• W2620795931 abstract "Among the plant derived product, azadirachtin, a neem-based insecticide, is exceptional in having a broad range of bioactivity including toxicity, growth, development and reproduction effects, repellency and antifeedancy. If considerable progress on the physiological and biological activities and agricultural application of azadirachtin has been achieved, its exact mechanism of action remains uncertain. In this study, we aimed at assessing the lethal and sublethal behavioral and physiological effects of azadirachtin on Drosophila melanogaster Meigen, 1830 (Diptera: Drosophilidae) as biological model. Azadirachtin was applied topically at two doses LD25 (0.28 μg) and LD50 (0.67 μg) on early third instar larvae. Results showed that flies preferentially ingested control medium rather than azadirachtin-treated medium. Pre-imaginal exposure (L3) to azadirachtin increased aversion to this substance suggesting a memorability of the learned avoidance. In addition, all tested flies revealed a clear preference for solvent odour rather than azadirachtin odour. Moreover, azadirachtin treatment decreased significantly the amount of food intake in the adults of both sexes. Finally, azadirachtin was found to affect digestive enzyme activities in the midgut of flies. Indeed, an inhibition of α-amylase, chitinase, and protease activities and an increase of lipasic activity were noted. These results may reflect interference of azadirachtin with regulation of feeding and metabolism, and provide some evidence of a long term antifeedancy and delayed effects through developmental stage which may reinforce the insecticidal activity of this bioinsecticide." @default.
• W2620795931 created "2017-06-09" @default.
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• W2620795931 date "2017-08-01" @default.
• W2620795931 modified "2023-10-16" @default.
• W2620795931 title "Preimaginal exposure to azadirachtin affects food selection and digestive enzymes in adults of Drosophila melanogaster (Diptera: Drosophilidae)" @default.
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• W2620795931 doi "https://doi.org/10.1016/j.pestbp.2017.06.004" @default.
• W2620795931 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28755695" @default.
• W2620795931 hasPublicationYear "2017" @default.
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