FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2620796620> ?p ?o ?g. }

• W2620796620 endingPage "115" @default.
• W2620796620 startingPage "104" @default.
• W2620796620 abstract "The transient receptor potential cation channel subfamily V member 1 (TRPV1), also known as the capsaicin receptor or vanilloid receptor 1 (VR1), is expressed in nociceptive neurons in the dorsal root ganglia (DRG) and participates in the transmission of pain. The present study investigated the underlying molecular mechanisms by which TRPV1 was regulated by nerve growth factor (NGF) signaling pathways in colonic hypersensitivity in response to colitis. We found that during colitis TRPV1 protein levels were significantly increased in specifically labeled colonic afferent neurons in both L1 and S1 DRGs. TRPV1 protein up-regulation in DRG was also enhanced by NGF treatment. We then found that TRPV1 protein up-regulation in DRG was regulated by activation of the phosphoinositide 3-kinase (PI3K)/Akt pathway both in vivo and in vitro. Suppression of endogenous PI3K/Akt activity during colitis or NGF treatment with a specific PI3K inhibitor LY294002 reduced TRPV1 protein production in DRG neurons, and also reduced colitis-evoked TRPV1-mediated visceral hypersensitivity tested by hyper-responsiveness to colorectal distention (CRD) and von Frey filament stimulation of abdomen. Further studies showed that TRPV1 mRNA levels in the DRG were not regulated by either colitis or NGF. We then found that an up-regulation of the protein synthesis pathway was involved by which both colitis and NGF caused a PI3K-dependent increase in the phosphorylation level of eukaryotic translation initiation factor 4E-binding protein (4E-BP)1. These results suggest a novel mechanism in colonic hypersensitivity which involves PI3K/Akt-mediated TRPV1 protein, not mRNA, up-regulation in primary afferent neurons, likely through activation of the protein synthesis pathways." @default.
• W2620796620 created "2017-06-09" @default.
• W2620796620 creator A5014760455 @default.
• W2620796620 creator A5039285070 @default.
• W2620796620 creator A5062970963 @default.
• W2620796620 creator A5081497411 @default.
• W2620796620 date "2017-09-01" @default.
• W2620796620 modified "2023-10-14" @default.
• W2620796620 title "Regulation of transient receptor potential cation channel subfamily V1 protein synthesis by the phosphoinositide 3-kinase/Akt pathway in colonic hypersensitivity" @default.
• W2620796620 cites W1550485358 @default.
• W2620796620 cites W1897402702 @default.
• W2620796620 cites W1914763441 @default.
• W2620796620 cites W1963789935 @default.
• W2620796620 cites W1963857381 @default.
• W2620796620 cites W1971263387 @default.
• W2620796620 cites W1976151711 @default.
• W2620796620 cites W1979915327 @default.
• W2620796620 cites W1982912226 @default.
• W2620796620 cites W1991136936 @default.
• W2620796620 cites W1993205491 @default.
• W2620796620 cites W2000104695 @default.
• W2620796620 cites W2005180409 @default.
• W2620796620 cites W2020268720 @default.
• W2620796620 cites W2023219363 @default.
• W2620796620 cites W2024556512 @default.
• W2620796620 cites W2031432874 @default.
• W2620796620 cites W2031586330 @default.
• W2620796620 cites W2032225587 @default.
• W2620796620 cites W2036649952 @default.
• W2620796620 cites W2038400469 @default.
• W2620796620 cites W2042970437 @default.
• W2620796620 cites W2047210289 @default.
• W2620796620 cites W2048066048 @default.
• W2620796620 cites W2060146354 @default.
• W2620796620 cites W2060948025 @default.
• W2620796620 cites W2063954888 @default.
• W2620796620 cites W2066442640 @default.
• W2620796620 cites W2067385623 @default.
• W2620796620 cites W2071657406 @default.
• W2620796620 cites W2074640318 @default.
• W2620796620 cites W2077343488 @default.
• W2620796620 cites W2079650065 @default.
• W2620796620 cites W2080289814 @default.
• W2620796620 cites W2089865983 @default.
• W2620796620 cites W2091396511 @default.
• W2620796620 cites W2094350954 @default.
• W2620796620 cites W2101546320 @default.
• W2620796620 cites W2103402799 @default.
• W2620796620 cites W2107988902 @default.
• W2620796620 cites W2115067440 @default.
• W2620796620 cites W2127459768 @default.
• W2620796620 cites W2137788707 @default.
• W2620796620 cites W2141539606 @default.
• W2620796620 cites W2142502825 @default.
• W2620796620 cites W2144537881 @default.
• W2620796620 cites W2156166679 @default.
• W2620796620 cites W2158380688 @default.
• W2620796620 cites W2160079255 @default.
• W2620796620 cites W2165979101 @default.
• W2620796620 cites W2168891784 @default.
• W2620796620 cites W2192208976 @default.
• W2620796620 cites W2338161804 @default.
• W2620796620 cites W4211114680 @default.
• W2620796620 cites W97582216 @default.
• W2620796620 doi "https://doi.org/10.1016/j.expneurol.2017.06.007" @default.
• W2620796620 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5535076" @default.
• W2620796620 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28587873" @default.
• W2620796620 hasPublicationYear "2017" @default.
• W2620796620 type Work @default.
• W2620796620 sameAs 2620796620 @default.
• W2620796620 citedByCount "22" @default.
• W2620796620 countsByYear W26207966202018 @default.
• W2620796620 countsByYear W26207966202019 @default.
• W2620796620 countsByYear W26207966202020 @default.
• W2620796620 countsByYear W26207966202021 @default.
• W2620796620 countsByYear W26207966202022 @default.
• W2620796620 countsByYear W26207966202023 @default.
• W2620796620 crossrefType "journal-article" @default.
• W2620796620 hasAuthorship W2620796620A5014760455 @default.
• W2620796620 hasAuthorship W2620796620A5039285070 @default.
• W2620796620 hasAuthorship W2620796620A5062970963 @default.
• W2620796620 hasAuthorship W2620796620A5081497411 @default.
• W2620796620 hasBestOaLocation W26207966202 @default.
• W2620796620 hasConcept C105702510 @default.
• W2620796620 hasConcept C126322002 @default.
• W2620796620 hasConcept C134018914 @default.
• W2620796620 hasConcept C140530291 @default.
• W2620796620 hasConcept C155164980 @default.
• W2620796620 hasConcept C160145004 @default.
• W2620796620 hasConcept C170493617 @default.
• W2620796620 hasConcept C185592680 @default.
• W2620796620 hasConcept C2775862500 @default.
• W2620796620 hasConcept C2776281502 @default.
• W2620796620 hasConcept C2776912716 @default.
• W2620796620 hasConcept C2778423431 @default.
• W2620796620 hasConcept C2781322055 @default.
• W2620796620 hasConcept C502942594 @default.
• W2620796620 hasConcept C55493867 @default.

• next