Matches in SemOpenAlex for { <https://semopenalex.org/work/W2620802335> ?p ?o ?g. }
- W2620802335 endingPage "5506" @default.
- W2620802335 startingPage "5493" @default.
- W2620802335 abstract "In this work, we report the multicomponent synthesis of a focused histone deacetylase (HDAC) inhibitor library with peptoid-based cap groups and different zinc-binding groups. All synthesized compounds were tested in a cellular HDAC inhibition assay and an MTT assay for cytotoxicity. On the basis of their noteworthy activity in the cellular HDAC assays, four compounds were further screened for their inhibitory activity against recombinant HDAC1–3, HDAC6, and HDAC8. All four compounds showed potent inhibition of HDAC1–3 as well as significant inhibition of HDAC6 with IC50 values in the submicromolar concentration range. Compound 4j, the most potent HDAC inhibitor in the cellular HDAC assay, revealed remarkable chemosensitizing properties and enhanced the cisplatin sensitivity of the cisplatin-resistant head–neck cancer cell line Cal27CisR by almost 7-fold. Furthermore, 4j almost completely reversed the cisplatin resistance in Cal27CisR. This effect is related to a synergistic induction of apoptosis as seen in the combination of 4j with cisplatin." @default.
- W2620802335 created "2017-06-09" @default.
- W2620802335 creator A5002848963 @default.
- W2620802335 creator A5003943852 @default.
- W2620802335 creator A5014802356 @default.
- W2620802335 creator A5016266091 @default.
- W2620802335 creator A5039406847 @default.
- W2620802335 creator A5044976489 @default.
- W2620802335 creator A5060303681 @default.
- W2620802335 creator A5060391945 @default.
- W2620802335 creator A5063949219 @default.
- W2620802335 creator A5064230603 @default.
- W2620802335 creator A5066801219 @default.
- W2620802335 creator A5087659225 @default.
- W2620802335 creator A5090497813 @default.
- W2620802335 date "2017-06-16" @default.
- W2620802335 modified "2023-09-25" @default.
- W2620802335 title "Design, Multicomponent Synthesis, and Anticancer Activity of a Focused Histone Deacetylase (HDAC) Inhibitor Library with Peptoid-Based Cap Groups" @default.
- W2620802335 cites W1493333783 @default.
- W2620802335 cites W1964248507 @default.
- W2620802335 cites W1964958542 @default.
- W2620802335 cites W1987193623 @default.
- W2620802335 cites W1997160178 @default.
- W2620802335 cites W1997757782 @default.
- W2620802335 cites W2000330869 @default.
- W2620802335 cites W2003356525 @default.
- W2620802335 cites W2006508993 @default.
- W2620802335 cites W2006978350 @default.
- W2620802335 cites W2008968950 @default.
- W2620802335 cites W2011171311 @default.
- W2620802335 cites W2014364284 @default.
- W2620802335 cites W2015122991 @default.
- W2620802335 cites W2023618081 @default.
- W2620802335 cites W2024616427 @default.
- W2620802335 cites W2027619236 @default.
- W2620802335 cites W2029148944 @default.
- W2620802335 cites W2029636016 @default.
- W2620802335 cites W2030571488 @default.
- W2620802335 cites W2032696829 @default.
- W2620802335 cites W2039984482 @default.
- W2620802335 cites W2041997366 @default.
- W2620802335 cites W2042806682 @default.
- W2620802335 cites W2055796578 @default.
- W2620802335 cites W2059683587 @default.
- W2620802335 cites W2062378498 @default.
- W2620802335 cites W2063078660 @default.
- W2620802335 cites W2063375109 @default.
- W2620802335 cites W2070361837 @default.
- W2620802335 cites W2080377507 @default.
- W2620802335 cites W2080854558 @default.
- W2620802335 cites W2086787471 @default.
- W2620802335 cites W2090033540 @default.
- W2620802335 cites W2090601659 @default.
- W2620802335 cites W2092476693 @default.
- W2620802335 cites W2094383719 @default.
- W2620802335 cites W2094691730 @default.
- W2620802335 cites W2095026025 @default.
- W2620802335 cites W2095399906 @default.
- W2620802335 cites W2099540110 @default.
- W2620802335 cites W2112918122 @default.
- W2620802335 cites W2116381732 @default.
- W2620802335 cites W2124706780 @default.
- W2620802335 cites W2126852131 @default.
- W2620802335 cites W2130867670 @default.
- W2620802335 cites W2133209813 @default.
- W2620802335 cites W2134406194 @default.
- W2620802335 cites W2140216615 @default.
- W2620802335 cites W2141037581 @default.
- W2620802335 cites W2144418931 @default.
- W2620802335 cites W2157830796 @default.
- W2620802335 cites W2158534713 @default.
- W2620802335 cites W2171645821 @default.
- W2620802335 cites W2238240583 @default.
- W2620802335 cites W2256019504 @default.
- W2620802335 cites W2275197865 @default.
- W2620802335 cites W2275536346 @default.
- W2620802335 cites W2333790767 @default.
- W2620802335 cites W2397502158 @default.
- W2620802335 cites W2400007510 @default.
- W2620802335 cites W2499955277 @default.
- W2620802335 cites W2507135630 @default.
- W2620802335 cites W2574603196 @default.
- W2620802335 doi "https://doi.org/10.1021/acs.jmedchem.7b00197" @default.
- W2620802335 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28574690" @default.
- W2620802335 hasPublicationYear "2017" @default.
- W2620802335 type Work @default.
- W2620802335 sameAs 2620802335 @default.
- W2620802335 citedByCount "30" @default.
- W2620802335 countsByYear W26208023352017 @default.
- W2620802335 countsByYear W26208023352018 @default.
- W2620802335 countsByYear W26208023352019 @default.
- W2620802335 countsByYear W26208023352020 @default.
- W2620802335 countsByYear W26208023352021 @default.
- W2620802335 countsByYear W26208023352022 @default.
- W2620802335 countsByYear W26208023352023 @default.
- W2620802335 crossrefType "journal-article" @default.
- W2620802335 hasAuthorship W2620802335A5002848963 @default.
- W2620802335 hasAuthorship W2620802335A5003943852 @default.