Matches in SemOpenAlex for { <https://semopenalex.org/work/W2620909969> ?p ?o ?g. }
- W2620909969 endingPage "730.e6" @default.
- W2620909969 startingPage "719" @default.
- W2620909969 abstract "Clearance of bacteria by macrophages involves internalization of the microorganisms into phagosomes, which are then delivered to endolysosomes for enzymatic degradation. These spatiotemporally segregated processes are not known to be functionally coupled. Here, we show that lysosomal degradation of bacteria sustains phagocytic uptake. In Drosophila and mammalian macrophages, lysosomal dysfunction due to loss of the endolysosomal Cl- transporter ClC-b/CLCN7 delayed degradation of internalized bacteria. Unexpectedly, defective lysosomal degradation of bacteria also attenuated further phagocytosis, resulting in elevated bacterial load. Exogenous application of bacterial peptidoglycans restored phagocytic uptake in the lysosomal degradation-defective mutants via a pathway requiring cytosolic pattern recognition receptors and NF-κB. Mammalian macrophages that are unable to degrade internalized bacteria also exhibit compromised NF-κB activation. Our findings reveal a role for phagolysosomal degradation in activating an evolutionarily conserved signaling cascade, which ensures that continuous uptake of bacteria is preceded by lysosomal degradation of microbes." @default.
- W2620909969 created "2017-06-09" @default.
- W2620909969 creator A5009544026 @default.
- W2620909969 creator A5017438792 @default.
- W2620909969 creator A5021311960 @default.
- W2620909969 creator A5026995692 @default.
- W2620909969 creator A5038232680 @default.
- W2620909969 creator A5042421898 @default.
- W2620909969 creator A5053247134 @default.
- W2620909969 creator A5055326453 @default.
- W2620909969 creator A5083024137 @default.
- W2620909969 creator A5086645286 @default.
- W2620909969 date "2017-06-01" @default.
- W2620909969 modified "2023-10-16" @default.
- W2620909969 title "Lysosomal Degradation Is Required for Sustained Phagocytosis of Bacteria by Macrophages" @default.
- W2620909969 cites W1572579115 @default.
- W2620909969 cites W1843274727 @default.
- W2620909969 cites W1859398825 @default.
- W2620909969 cites W1970997423 @default.
- W2620909969 cites W1972781757 @default.
- W2620909969 cites W1973643962 @default.
- W2620909969 cites W1978170970 @default.
- W2620909969 cites W1979881131 @default.
- W2620909969 cites W1987401543 @default.
- W2620909969 cites W1989735320 @default.
- W2620909969 cites W1998741829 @default.
- W2620909969 cites W1999257669 @default.
- W2620909969 cites W2001389730 @default.
- W2620909969 cites W2002047195 @default.
- W2620909969 cites W2009604662 @default.
- W2620909969 cites W2017593971 @default.
- W2620909969 cites W2020016337 @default.
- W2620909969 cites W2031113436 @default.
- W2620909969 cites W2032355912 @default.
- W2620909969 cites W2037127114 @default.
- W2620909969 cites W2041143337 @default.
- W2620909969 cites W2042433863 @default.
- W2620909969 cites W2050340611 @default.
- W2620909969 cites W2053785468 @default.
- W2620909969 cites W2055807373 @default.
- W2620909969 cites W2073115188 @default.
- W2620909969 cites W2075583035 @default.
- W2620909969 cites W2077906612 @default.
- W2620909969 cites W2093649371 @default.
- W2620909969 cites W2103104037 @default.
- W2620909969 cites W2103546861 @default.
- W2620909969 cites W2106684817 @default.
- W2620909969 cites W2116298621 @default.
- W2620909969 cites W2120788536 @default.
- W2620909969 cites W2135919238 @default.
- W2620909969 cites W2142293553 @default.
- W2620909969 cites W2152457344 @default.
- W2620909969 cites W2161818114 @default.
- W2620909969 cites W4213174091 @default.
- W2620909969 doi "https://doi.org/10.1016/j.chom.2017.05.002" @default.
- W2620909969 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5540652" @default.
- W2620909969 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28579255" @default.
- W2620909969 hasPublicationYear "2017" @default.
- W2620909969 type Work @default.
- W2620909969 sameAs 2620909969 @default.
- W2620909969 citedByCount "65" @default.
- W2620909969 countsByYear W26209099692017 @default.
- W2620909969 countsByYear W26209099692018 @default.
- W2620909969 countsByYear W26209099692019 @default.
- W2620909969 countsByYear W26209099692020 @default.
- W2620909969 countsByYear W26209099692021 @default.
- W2620909969 countsByYear W26209099692022 @default.
- W2620909969 countsByYear W26209099692023 @default.
- W2620909969 crossrefType "journal-article" @default.
- W2620909969 hasAuthorship W2620909969A5009544026 @default.
- W2620909969 hasAuthorship W2620909969A5017438792 @default.
- W2620909969 hasAuthorship W2620909969A5021311960 @default.
- W2620909969 hasAuthorship W2620909969A5026995692 @default.
- W2620909969 hasAuthorship W2620909969A5038232680 @default.
- W2620909969 hasAuthorship W2620909969A5042421898 @default.
- W2620909969 hasAuthorship W2620909969A5053247134 @default.
- W2620909969 hasAuthorship W2620909969A5055326453 @default.
- W2620909969 hasAuthorship W2620909969A5083024137 @default.
- W2620909969 hasAuthorship W2620909969A5086645286 @default.
- W2620909969 hasBestOaLocation W26209099691 @default.
- W2620909969 hasConcept C102747710 @default.
- W2620909969 hasConcept C120694314 @default.
- W2620909969 hasConcept C139770010 @default.
- W2620909969 hasConcept C160448771 @default.
- W2620909969 hasConcept C161478664 @default.
- W2620909969 hasConcept C170493617 @default.
- W2620909969 hasConcept C181199279 @default.
- W2620909969 hasConcept C190283241 @default.
- W2620909969 hasConcept C202751555 @default.
- W2620909969 hasConcept C203522944 @default.
- W2620909969 hasConcept C2779244956 @default.
- W2620909969 hasConcept C2780216420 @default.
- W2620909969 hasConcept C28005876 @default.
- W2620909969 hasConcept C523546767 @default.
- W2620909969 hasConcept C54355233 @default.
- W2620909969 hasConcept C55493867 @default.
- W2620909969 hasConcept C79879829 @default.
- W2620909969 hasConcept C86803240 @default.