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- W2620933897 endingPage "109" @default.
- W2620933897 startingPage "62" @default.
- W2620933897 abstract "In the 1980s Maeda and his colleagues discover a unique phenomenon called the enhanced permeability and retention (EPR) effect. This phenomenon describes the facilitated extravasation of macromolecular drugs more selectively at tumor tissues due to the distinctive tumor vasculature and to the ability of macromolecules to attain prolonged plasma or local half-lives. Since then, this discovery has directed research toward constructing, loading, and administering macromolecular nanoconstructs with different drug molecules to target tumor tissue more selectively and effectively. Currently, many EPR-based nanomedicines are in different phases of clinical trials while some have already been approved for use in the clinic. In this chapter, we discuss the principle, features, and factors contributing to the EPR effect. We also highlight the types and characteristics of EPR-based nanoconstructs. Moreover, we discuss the main limitations that hinder taking the full advantage of EPR-based nanomedicines and finally we discuss the future prospects to face these limitations to enhance EPR-based nanomedicines transition to the clinic." @default.
- W2620933897 created "2017-06-09" @default.
- W2620933897 creator A5006902177 @default.
- W2620933897 creator A5083448333 @default.
- W2620933897 creator A5091405085 @default.
- W2620933897 date "2017-01-01" @default.
- W2620933897 modified "2023-10-15" @default.
- W2620933897 title "Current Update on the Role of Enhanced Permeability and Retention Effect in Cancer Nanomedicine" @default.
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