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- W2620959971 abstract "In spite of treatment with the current standard of care antiplatelet regimens including dual antiplatelet therapy, recurrence rates of ischemic events remain elevated for high-risk patients with atherosclerotic disease. This may be in part attributed to the fact that other key platelet activation pathways remain uninhibited and can thus continue to trigger platelet activation and lead to thrombotic complications. Thrombin is a powerful inducer of platelet activation and mediates its effects directly on platelets through protease activator receptors (PARs), particularly the PAR-1 subtype, making PAR-1 inhibition an attractive approach for reducing atherothrombotic events. These observations have led to the development of several PAR-1 antagonists. Vorapaxar is a direct inhibitor of PAR-1 and the only agent of this class approved for the prevention of recurrent ischemic events in patients with prior myocardial infarction or peripheral artery disease. In the present manuscript, we present a review of the pathophysiologic role of thrombin on thrombotic complications, the impact of vorapaxar on outcomes, including the most recent updates deriving from clinical trials, as well as future perspectives in the field." @default.
- W2620959971 created "2017-06-09" @default.
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- W2620959971 date "2017-05-31" @default.
- W2620959971 modified "2023-09-27" @default.
- W2620959971 title "Role for Thrombin Receptor Antagonism With Vorapaxar in Secondary Prevention of Atherothrombotic Events: From Bench to Bedside" @default.
- W2620959971 cites W1233730209 @default.
- W2620959971 cites W1485191699 @default.
- W2620959971 cites W1504954231 @default.
- W2620959971 cites W1553345686 @default.
- W2620959971 cites W1907663636 @default.
- W2620959971 cites W191849520 @default.
- W2620959971 cites W1930503019 @default.
- W2620959971 cites W1948406140 @default.
- W2620959971 cites W1963938486 @default.
- W2620959971 cites W1964067479 @default.
- W2620959971 cites W1966562996 @default.
- W2620959971 cites W1980287140 @default.
- W2620959971 cites W1986266381 @default.
- W2620959971 cites W1990381860 @default.
- W2620959971 cites W1991372259 @default.
- W2620959971 cites W1996056369 @default.
- W2620959971 cites W1997519752 @default.
- W2620959971 cites W2013172045 @default.
- W2620959971 cites W2018383335 @default.
- W2620959971 cites W2019661749 @default.
- W2620959971 cites W2023056589 @default.
- W2620959971 cites W2033021604 @default.
- W2620959971 cites W2044658006 @default.
- W2620959971 cites W2045872180 @default.
- W2620959971 cites W2046011250 @default.
- W2620959971 cites W2049344791 @default.
- W2620959971 cites W205013270 @default.
- W2620959971 cites W2056151177 @default.
- W2620959971 cites W2058217708 @default.
- W2620959971 cites W2058252463 @default.
- W2620959971 cites W2058326090 @default.
- W2620959971 cites W2058915460 @default.
- W2620959971 cites W2065955007 @default.
- W2620959971 cites W2067972505 @default.
- W2620959971 cites W2068520355 @default.
- W2620959971 cites W2073737948 @default.
- W2620959971 cites W2081615170 @default.
- W2620959971 cites W2083272472 @default.
- W2620959971 cites W2085302164 @default.
- W2620959971 cites W2086404974 @default.
- W2620959971 cites W2086976004 @default.
- W2620959971 cites W2091112630 @default.
- W2620959971 cites W2093117751 @default.
- W2620959971 cites W2102785524 @default.
- W2620959971 cites W2104810826 @default.
- W2620959971 cites W2104969665 @default.
- W2620959971 cites W2105735830 @default.
- W2620959971 cites W2113441742 @default.
- W2620959971 cites W2115558889 @default.
- W2620959971 cites W2122082665 @default.
- W2620959971 cites W2123673539 @default.
- W2620959971 cites W2127160975 @default.
- W2620959971 cites W2130615932 @default.
- W2620959971 cites W2134322421 @default.
- W2620959971 cites W2140501627 @default.
- W2620959971 cites W2142004106 @default.
- W2620959971 cites W2142021807 @default.
- W2620959971 cites W2152813238 @default.
- W2620959971 cites W2154382954 @default.
- W2620959971 cites W2156725039 @default.
- W2620959971 cites W2158306641 @default.
- W2620959971 cites W2158910198 @default.
- W2620959971 cites W2164915878 @default.
- W2620959971 cites W2165325119 @default.
- W2620959971 cites W2165614730 @default.
- W2620959971 cites W2166196321 @default.
- W2620959971 cites W2166268102 @default.
- W2620959971 cites W2169387542 @default.
- W2620959971 cites W2174434727 @default.
- W2620959971 cites W2234841805 @default.
- W2620959971 cites W2295484744 @default.
- W2620959971 cites W2339352537 @default.
- W2620959971 cites W2481987364 @default.
- W2620959971 cites W2492202010 @default.
- W2620959971 cites W2498004564 @default.
- W2620959971 cites W2544128045 @default.
- W2620959971 cites W2556414715 @default.
- W2620959971 cites W2590563478 @default.
- W2620959971 cites W311320695 @default.
- W2620959971 cites W4236878386 @default.
- W2620959971 cites W4292856638 @default.
- W2620959971 doi "https://doi.org/10.1177/1074248417708617" @default.
- W2620959971 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28565918" @default.
- W2620959971 hasPublicationYear "2017" @default.
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