Matches in SemOpenAlex for { <https://semopenalex.org/work/W2620996986> ?p ?o ?g. }
Showing items 1 to 95 of
95
with 100 items per page.
- W2620996986 endingPage "S45" @default.
- W2620996986 startingPage "S43" @default.
- W2620996986 abstract "In experimental diabetic and nondiabetic chronic kidney disease, angiotensin-converting enzyme (ACE) inhibitor and angiotensin receptor blockers (ARB) combination therapy reduce proteinuria and prevent structural lesions more effectively than either drug alone. Consistently, in humans, a multidrug individually tailored antiproteinuric treatment based on combination therapy with maximum tolerated doses of angiotensin-converting enzyme inhibitors and angiotensin receptor blockers (“Remission Clinic”) reduced proteinuria and prevented end-stage renal disease more effectively than angiotensin-converting enzyme/angiotensin receptor blockers monotherapy, in particular in subjects with nondiabetic chronic kidney disease. Fixed doses of an angiotensin-converting enzyme inhibitor or renin inhibitor added-on losartan failed to exert any additional renoprotective effect as compared with losartan monotherapy in patients with type 2 diabetes and overt nephropathy. However, the VA NEPHRON D study found that losartan and lisinopril combination therapy reduced by 34 % the risk of pre-defined reductions in estimated glomerular filtration rate, end-stage renal disease or death as compared to losartan in 1448 type 2 diabetes patients with overt nephropathy. Unfortunately, treatment effect failed to achieve the nominal significance (P = 0.07) because of premature trial interruption. Thus, the Remission Clinic protocol is the most powerful tool to prevent progression to end-stage renal disease in nondiabetic proteinuric chronic kidney disease. Results of the ongoing VALID trial will show whether this approach can be safely extended to type 2 diabetes patients." @default.
- W2620996986 created "2017-06-09" @default.
- W2620996986 creator A5059276594 @default.
- W2620996986 date "2017-04-01" @default.
- W2620996986 modified "2023-09-30" @default.
- W2620996986 title "Dual renin–angiotensin system blockade for nephroprotection" @default.
- W2620996986 cites W180946982 @default.
- W2620996986 cites W1984313472 @default.
- W2620996986 cites W2019639026 @default.
- W2620996986 cites W2049823841 @default.
- W2620996986 cites W2050071967 @default.
- W2620996986 cites W2056976690 @default.
- W2620996986 cites W2096875294 @default.
- W2620996986 cites W2100409734 @default.
- W2620996986 cites W2124602789 @default.
- W2620996986 cites W2138862624 @default.
- W2620996986 cites W2162368776 @default.
- W2620996986 cites W2528117989 @default.
- W2620996986 doi "https://doi.org/10.1016/j.nephro.2017.02.006" @default.
- W2620996986 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28577742" @default.
- W2620996986 hasPublicationYear "2017" @default.
- W2620996986 type Work @default.
- W2620996986 sameAs 2620996986 @default.
- W2620996986 citedByCount "6" @default.
- W2620996986 countsByYear W26209969862019 @default.
- W2620996986 countsByYear W26209969862020 @default.
- W2620996986 countsByYear W26209969862021 @default.
- W2620996986 countsByYear W26209969862022 @default.
- W2620996986 crossrefType "journal-article" @default.
- W2620996986 hasAuthorship W2620996986A5059276594 @default.
- W2620996986 hasConcept C104849204 @default.
- W2620996986 hasConcept C126322002 @default.
- W2620996986 hasConcept C126894567 @default.
- W2620996986 hasConcept C134018914 @default.
- W2620996986 hasConcept C159641895 @default.
- W2620996986 hasConcept C170493617 @default.
- W2620996986 hasConcept C27016395 @default.
- W2620996986 hasConcept C2777880890 @default.
- W2620996986 hasConcept C2778653478 @default.
- W2620996986 hasConcept C2779134260 @default.
- W2620996986 hasConcept C2779561371 @default.
- W2620996986 hasConcept C2779611605 @default.
- W2620996986 hasConcept C2779922275 @default.
- W2620996986 hasConcept C2780091579 @default.
- W2620996986 hasConcept C2780288358 @default.
- W2620996986 hasConcept C2781184683 @default.
- W2620996986 hasConcept C2908929049 @default.
- W2620996986 hasConcept C3019040382 @default.
- W2620996986 hasConcept C555293320 @default.
- W2620996986 hasConcept C71924100 @default.
- W2620996986 hasConcept C84393581 @default.
- W2620996986 hasConcept C98274493 @default.
- W2620996986 hasConceptScore W2620996986C104849204 @default.
- W2620996986 hasConceptScore W2620996986C126322002 @default.
- W2620996986 hasConceptScore W2620996986C126894567 @default.
- W2620996986 hasConceptScore W2620996986C134018914 @default.
- W2620996986 hasConceptScore W2620996986C159641895 @default.
- W2620996986 hasConceptScore W2620996986C170493617 @default.
- W2620996986 hasConceptScore W2620996986C27016395 @default.
- W2620996986 hasConceptScore W2620996986C2777880890 @default.
- W2620996986 hasConceptScore W2620996986C2778653478 @default.
- W2620996986 hasConceptScore W2620996986C2779134260 @default.
- W2620996986 hasConceptScore W2620996986C2779561371 @default.
- W2620996986 hasConceptScore W2620996986C2779611605 @default.
- W2620996986 hasConceptScore W2620996986C2779922275 @default.
- W2620996986 hasConceptScore W2620996986C2780091579 @default.
- W2620996986 hasConceptScore W2620996986C2780288358 @default.
- W2620996986 hasConceptScore W2620996986C2781184683 @default.
- W2620996986 hasConceptScore W2620996986C2908929049 @default.
- W2620996986 hasConceptScore W2620996986C3019040382 @default.
- W2620996986 hasConceptScore W2620996986C555293320 @default.
- W2620996986 hasConceptScore W2620996986C71924100 @default.
- W2620996986 hasConceptScore W2620996986C84393581 @default.
- W2620996986 hasConceptScore W2620996986C98274493 @default.
- W2620996986 hasLocation W26209969861 @default.
- W2620996986 hasLocation W26209969862 @default.
- W2620996986 hasOpenAccess W2620996986 @default.
- W2620996986 hasPrimaryLocation W26209969861 @default.
- W2620996986 hasRelatedWork W1998038903 @default.
- W2620996986 hasRelatedWork W2037598090 @default.
- W2620996986 hasRelatedWork W2052526306 @default.
- W2620996986 hasRelatedWork W2054881161 @default.
- W2620996986 hasRelatedWork W2094764416 @default.
- W2620996986 hasRelatedWork W2290424579 @default.
- W2620996986 hasRelatedWork W2359443551 @default.
- W2620996986 hasRelatedWork W2597005861 @default.
- W2620996986 hasRelatedWork W2974342528 @default.
- W2620996986 hasRelatedWork W63130948 @default.
- W2620996986 hasVolume "13" @default.
- W2620996986 isParatext "false" @default.
- W2620996986 isRetracted "false" @default.
- W2620996986 magId "2620996986" @default.
- W2620996986 workType "article" @default.