FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2621074037> ?p ?o ?g. }

• W2621074037 endingPage "570" @default.
• W2621074037 startingPage "564" @default.
• W2621074037 abstract "Protein tyrosine phosphorylation guides many molecular interactions for cellular functions. SCIMP is a transmembrane adaptor protein (TRAP) family member that mediates selective proinflammatory cytokine responses generated by pathogen‐activated Toll‐like receptor (TLR) pathways in macrophages. TLR activation triggers SCIMP phosphorylation and selective phosphorylation of distinct tyrosine residues on this adaptor offers the potential for regulating or biasing inflammatory responses. To analyze site‐specific phosphorylation events, we developed three probes based on the SH2 domains of known SCIMP effectors, and used them for pull‐downs from macrophage extracts. CRISPR‐mediated SCIMP‐deficient RAW264.7 macrophage‐like cells were reconstituted with various phosphorylation‐deficient (Y58F, Y96F, Y120F) SCIMPs, and used to demonstrate the specificity of LPS/TLR4‐induced, site‐specific phosphorylation of SCIMP for the temporal recruitment of the effectors Grb2, Csk and SLP65. Our findings reveal potential for differential SCIMP phosphorylation and specific effectors to influence TLR signaling and inflammatory programs. Furthermore, the use of Csk‐SH2 pull‐downs to identify additional known and new Csk targets in LPS‐activated macrophages reveals the wider utility of our SH2 probes." @default.
• W2621074037 created "2017-06-09" @default.
• W2621074037 creator A5022945502 @default.
• W2621074037 creator A5023814339 @default.
• W2621074037 creator A5026924357 @default.
• W2621074037 creator A5040894479 @default.
• W2621074037 creator A5052494090 @default.
• W2621074037 creator A5074973768 @default.
• W2621074037 date "2017-03-14" @default.
• W2621074037 modified "2023-10-15" @default.
• W2621074037 title "Development of SH2 probes and pull‐down assays to detect pathogen‐induced, site‐specific tyrosine phosphorylation of the TLR adaptor SCIMP" @default.
• W2621074037 cites W164293537 @default.
• W2621074037 cites W1727774600 @default.
• W2621074037 cites W1845552116 @default.
• W2621074037 cites W1937837640 @default.
• W2621074037 cites W1969708405 @default.
• W2621074037 cites W1971201797 @default.
• W2621074037 cites W1974745521 @default.
• W2621074037 cites W1980843814 @default.
• W2621074037 cites W2001638852 @default.
• W2621074037 cites W2004077304 @default.
• W2621074037 cites W2009818164 @default.
• W2621074037 cites W2024727248 @default.
• W2621074037 cites W2034341688 @default.
• W2621074037 cites W2055519466 @default.
• W2621074037 cites W2058527576 @default.
• W2621074037 cites W2070983416 @default.
• W2621074037 cites W2083374779 @default.
• W2621074037 cites W2089428013 @default.
• W2621074037 cites W2098415113 @default.
• W2621074037 cites W2103344750 @default.
• W2621074037 cites W2138329729 @default.
• W2621074037 cites W2144121653 @default.
• W2621074037 cites W2164004507 @default.
• W2621074037 cites W2164682544 @default.
• W2621074037 cites W2178587031 @default.
• W2621074037 cites W2419130452 @default.
• W2621074037 cites W2579687242 @default.
• W2621074037 doi "https://doi.org/10.1038/icb.2017.10" @default.
• W2621074037 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28290451" @default.
• W2621074037 hasPublicationYear "2017" @default.
• W2621074037 type Work @default.
• W2621074037 sameAs 2621074037 @default.
• W2621074037 citedByCount "6" @default.
• W2621074037 countsByYear W26210740372018 @default.
• W2621074037 countsByYear W26210740372019 @default.
• W2621074037 countsByYear W26210740372022 @default.
• W2621074037 crossrefType "journal-article" @default.
• W2621074037 hasAuthorship W2621074037A5022945502 @default.
• W2621074037 hasAuthorship W2621074037A5023814339 @default.
• W2621074037 hasAuthorship W2621074037A5026924357 @default.
• W2621074037 hasAuthorship W2621074037A5040894479 @default.
• W2621074037 hasAuthorship W2621074037A5052494090 @default.
• W2621074037 hasAuthorship W2621074037A5074973768 @default.
• W2621074037 hasBestOaLocation W26210740371 @default.
• W2621074037 hasConcept C11960822 @default.
• W2621074037 hasConcept C164027704 @default.
• W2621074037 hasConcept C177917778 @default.
• W2621074037 hasConcept C183786373 @default.
• W2621074037 hasConcept C185592680 @default.
• W2621074037 hasConcept C197153747 @default.
• W2621074037 hasConcept C203014093 @default.
• W2621074037 hasConcept C2776914184 @default.
• W2621074037 hasConcept C2777553839 @default.
• W2621074037 hasConcept C51785407 @default.
• W2621074037 hasConcept C62478195 @default.
• W2621074037 hasConcept C86803240 @default.
• W2621074037 hasConcept C95444343 @default.
• W2621074037 hasConceptScore W2621074037C11960822 @default.
• W2621074037 hasConceptScore W2621074037C164027704 @default.
• W2621074037 hasConceptScore W2621074037C177917778 @default.
• W2621074037 hasConceptScore W2621074037C183786373 @default.
• W2621074037 hasConceptScore W2621074037C185592680 @default.
• W2621074037 hasConceptScore W2621074037C197153747 @default.
• W2621074037 hasConceptScore W2621074037C203014093 @default.
• W2621074037 hasConceptScore W2621074037C2776914184 @default.
• W2621074037 hasConceptScore W2621074037C2777553839 @default.
• W2621074037 hasConceptScore W2621074037C51785407 @default.
• W2621074037 hasConceptScore W2621074037C62478195 @default.
• W2621074037 hasConceptScore W2621074037C86803240 @default.
• W2621074037 hasConceptScore W2621074037C95444343 @default.
• W2621074037 hasFunder F4320334705 @default.
• W2621074037 hasFunder F4320338275 @default.
• W2621074037 hasIssue "6" @default.
• W2621074037 hasLocation W26210740371 @default.
• W2621074037 hasLocation W26210740372 @default.
• W2621074037 hasOpenAccess W2621074037 @default.
• W2621074037 hasPrimaryLocation W26210740371 @default.
• W2621074037 hasRelatedWork W1958242816 @default.
• W2621074037 hasRelatedWork W2005167514 @default.
• W2621074037 hasRelatedWork W2066039346 @default.
• W2621074037 hasRelatedWork W2075285806 @default.
• W2621074037 hasRelatedWork W2085432552 @default.
• W2621074037 hasRelatedWork W2111844459 @default.
• W2621074037 hasRelatedWork W2411955162 @default.
• W2621074037 hasRelatedWork W2621074037 @default.
• W2621074037 hasRelatedWork W2768556704 @default.
• W2621074037 hasRelatedWork W4244477508 @default.

• next