FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2621079720> ?p ?o ?g. }

• W2621079720 endingPage "206" @default.
• W2621079720 startingPage "190" @default.
• W2621079720 abstract "Deoxyelephantopin (DOE) is a natural bioactive sesquiterpene lactone from Elephantopus scaber, a traditionally relevant herb in Chinese and Indian medicine. It has shown promising anticancer effects against a broad spectrum of cancers.We examined the effect of DOE on growth, autophagy, apoptosis, cell cycle progression, metastasis, and various molecular signaling pathways in cancer cells, and endeavored to decipher the molecular mechanisms underlying its effect. The cytotoxicity of DOE was examined by MTT (3-[4,5-dimethylthiazol-2-yl]-2,5-diphenyltetrazolium bromide) and colony formation assays. The antimetastatic potential of DOE was identified by wound closure, as well as invasion and migration assays. The expression of mRNAs and proteins related to cytotoxicity in cancer cells induced by DOE was investigated using reverse transcription-polymerase chain reaction, flow cytometry, and Western blot analysis.DOE showed significant cytotoxicity and induced apoptosis in cancer cells. DOE promoted the autophagy of HCT 116 and K562 cells. DOE arrested cell cycle progression in the G2/M phase. DOE treatment caused activation of caspase-8, -9, -3 and -7, reactive oxygen species production, and cleavage of cleavage of poly-ADP-ribose polymerase (PARP), the markers of apoptosis. Moreover, apoptosis induction was associated with mitochondrial permeability and endoplasmic reticulum stress. Treatment of cancer cells with DOE inhibited mitogen-activated protein kinases, nuclear factor-kappa B, phosphatidylinositol 3-kinase (PI3K/Akt), and β-catenin signaling. Furthermore, treatment of DOE increased the expression of p53, phospho-Jun amino-terminal kinases (p-JNK), and p-p38 and decreased the expression of phospho-signal transducer and activator of transcription 3 (p-STAT3) and phospho-mammalian target of rapamycin (p-mTOR) in cancer cells. DOE downregulated matrix metalloproteinase (MMP-2) and MMP-9, urokinase-type plasminogen activator (uPA), and urokinase-type plasminogen activator receptor (uPAR) mRNA levels in cancer cells.These findings concluded that DOE may be useful as a chemotherapeutic agent against cancer." @default.
• W2621079720 created "2017-06-09" @default.
• W2621079720 creator A5008453313 @default.
• W2621079720 creator A5018888962 @default.
• W2621079720 creator A5028021022 @default.
• W2621079720 creator A5063830363 @default.
• W2621079720 date "2017-06-01" @default.
• W2621079720 modified "2023-09-27" @default.
• W2621079720 title "Molecular mechanisms of anticancer activity of deoxyelephantopin in cancer cells" @default.
• W2621079720 cites W1502277990 @default.
• W2621079720 cites W1546139069 @default.
• W2621079720 cites W1720078464 @default.
• W2621079720 cites W1965734230 @default.
• W2621079720 cites W1967880683 @default.
• W2621079720 cites W1968458167 @default.
• W2621079720 cites W1987490683 @default.
• W2621079720 cites W1991075835 @default.
• W2621079720 cites W1992435071 @default.
• W2621079720 cites W2001399725 @default.
• W2621079720 cites W2003060606 @default.
• W2621079720 cites W2005476730 @default.
• W2621079720 cites W2012780861 @default.
• W2621079720 cites W2024282024 @default.
• W2621079720 cites W2030213143 @default.
• W2621079720 cites W2034915619 @default.
• W2621079720 cites W2035117037 @default.
• W2621079720 cites W2065681532 @default.
• W2621079720 cites W2076515532 @default.
• W2621079720 cites W2076718605 @default.
• W2621079720 cites W2077397852 @default.
• W2621079720 cites W2078100331 @default.
• W2621079720 cites W2083444507 @default.
• W2621079720 cites W2083623093 @default.
• W2621079720 cites W2088186353 @default.
• W2621079720 cites W2098439946 @default.
• W2621079720 cites W2108300681 @default.
• W2621079720 cites W2117726975 @default.
• W2621079720 cites W2120492514 @default.
• W2621079720 cites W2121797708 @default.
• W2621079720 cites W2124961982 @default.
• W2621079720 cites W2128016549 @default.
• W2621079720 cites W2128258072 @default.
• W2621079720 cites W2128568558 @default.
• W2621079720 cites W2129023633 @default.
• W2621079720 cites W2129842734 @default.
• W2621079720 cites W2136283919 @default.
• W2621079720 cites W2143645520 @default.
• W2621079720 cites W2148200419 @default.
• W2621079720 cites W2150048195 @default.
• W2621079720 cites W2163143576 @default.
• W2621079720 cites W2166251636 @default.
• W2621079720 cites W2169238639 @default.
• W2621079720 cites W2323425273 @default.
• W2621079720 cites W2396138830 @default.
• W2621079720 cites W2411707573 @default.
• W2621079720 cites W1964184380 @default.
• W2621079720 cites W1996773822 @default.
• W2621079720 doi "https://doi.org/10.1016/j.imr.2017.03.004" @default.
• W2621079720 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5478298" @default.
• W2621079720 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28664142" @default.
• W2621079720 hasPublicationYear "2017" @default.
• W2621079720 type Work @default.
• W2621079720 sameAs 2621079720 @default.
• W2621079720 citedByCount "23" @default.
• W2621079720 countsByYear W26210797202018 @default.
• W2621079720 countsByYear W26210797202019 @default.
• W2621079720 countsByYear W26210797202020 @default.
• W2621079720 countsByYear W26210797202021 @default.
• W2621079720 countsByYear W26210797202022 @default.
• W2621079720 countsByYear W26210797202023 @default.
• W2621079720 crossrefType "journal-article" @default.
• W2621079720 hasAuthorship W2621079720A5008453313 @default.
• W2621079720 hasAuthorship W2621079720A5018888962 @default.
• W2621079720 hasAuthorship W2621079720A5028021022 @default.
• W2621079720 hasAuthorship W2621079720A5063830363 @default.
• W2621079720 hasBestOaLocation W26210797201 @default.
• W2621079720 hasConcept C121608353 @default.
• W2621079720 hasConcept C153911025 @default.
• W2621079720 hasConcept C184235292 @default.
• W2621079720 hasConcept C185592680 @default.
• W2621079720 hasConcept C190283241 @default.
• W2621079720 hasConcept C29537977 @default.
• W2621079720 hasConcept C502942594 @default.
• W2621079720 hasConcept C51551487 @default.
• W2621079720 hasConcept C54355233 @default.
• W2621079720 hasConcept C55493867 @default.
• W2621079720 hasConcept C75217442 @default.
• W2621079720 hasConcept C86554907 @default.
• W2621079720 hasConcept C86803240 @default.
• W2621079720 hasConcept C95444343 @default.
• W2621079720 hasConcept C96232424 @default.
• W2621079720 hasConcept C97029542 @default.
• W2621079720 hasConceptScore W2621079720C121608353 @default.
• W2621079720 hasConceptScore W2621079720C153911025 @default.
• W2621079720 hasConceptScore W2621079720C184235292 @default.
• W2621079720 hasConceptScore W2621079720C185592680 @default.
• W2621079720 hasConceptScore W2621079720C190283241 @default.
• W2621079720 hasConceptScore W2621079720C29537977 @default.

• next