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- W2621083019 abstract "The approximations embedded in the single compartment description of glucose kinetics used in the minimal models are investigated using a model of the glucose-insulin system, to generate a high number of noisy synthetic data sets of glucose, tracer glucose and insulin plasma concentrations during an IVGTT, which are then analyzed with the minimal models of glucose and tracer glucose disappearance. The metabolic indices of glucose effectiveness and insulin sensitivity (liver+periphery and periphery) such obtained are compared with the “true” ones yielded by the model generating the data. Results show that (1) the minimal model glucose effectiveness is uncorre1ated with the corresponding simulationmodel index, (2) minimal model insulin sensitivity (liver+periphery) is well correlated with the simulation model insulin sensitivity, but severely underestimates it, (3) minimal model clearance rate is well correlated with the simulation model one, and (4) insulin sensitivity (periphery) estiDiated by the minimal model slightly underestimates the corresponding measure of the simulation model." @default.
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- W2621083019 date "1997-03-01" @default.
- W2621083019 modified "2023-09-25" @default.
- W2621083019 title "Minimal Models of Glucose Disappearance: Effect of Undermodeling Assessed by Monte Carlo Simulation" @default.
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- W2621083019 doi "https://doi.org/10.1016/s1474-6670(17)44548-4" @default.
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