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- W2621131204 abstract "With the recent explosion of biotherapeutic drugs, protein quantification is required from the earliest stages of discovery to understand target biology, perform pharmacokinetic (PK) analysis, and to understand biotransformation of peptide and protein biotherapeutics. In order to quantify proteins in the pg/mL range, the practice of combining immunoaffinity capture with MS detection or immunoaffinity-mass spectrometry (IA-MS) was introduced. At a high level, IA-MS methods can be classified into two groups according to whether the antibody reagents used target an intact protein or a surrogate peptide produced by proteolytic digestion during sample processing. In the years ahead, the notion of combining IA sample preparation with MS detection will become commonplace in laboratories studying either protein biomarkers or biotherapeutics. Pharmaceutical laboratories, which tend to be well supplied with MS instrumentation, will increasingly invest in the cross-training necessary to establish a workforce having comparable fluency in MS and ligand binding assay (LBA) methods." @default.
- W2621131204 created "2017-06-09" @default.
- W2621131204 creator A5030558866 @default.
- W2621131204 creator A5035369011 @default.
- W2621131204 date "2017-06-02" @default.
- W2621131204 modified "2023-10-17" @default.
- W2621131204 title "The Application of Immunoaffinity‐Based Mass Spectrometry to Characterize Protein Biomarkers and Biotherapeutics" @default.
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