FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2621189585> ?p ?o ?g. }

• W2621189585 endingPage "1101" @default.
• W2621189585 startingPage "1091" @default.
• W2621189585 abstract "OBJECTIVE High-grade glial brain tumors are often characterized by an elevated expression of the tumorigenic epidermal growth factor receptor variant III ( EGFRvIII ). The authors sought to establish a clinically adaptive protocol as a noninvasive diagnostic tool for EGFRvIII detection through serum exosomes. METHODS Purity of serum exosome/RNA was confirmed by electron microscopy and flow cytometry and through an RNA bioanalyzer profile. EGFRvIII amplification was initially established by semiquantitative polymerase chain reaction in tumor tissues and exosomes. Diagnostic performance of EGFRvIII transcript in tissue versus exosome was determined using a 2 × 2 clinical table approach. Overall survival was determined using Kaplan-Meier analysis. RESULTS The EGFRvIII transcript was detected in 39.5% of tumor tissue samples and in 44.7% of their paired serum exosome samples; 28.1% of biopsy tumors coexpressed wild-type EGFR and EGFRvIII . Tissue EGFRvIII amplification served as the reference-positive control for its paired serum expression. The overall clinical sensitivity and specificity of semiquantitative exosome EGFRvIII polymerase chain reaction detection assay in serum were 81.58% (95% CI 65.67%–92.26%) and 79.31% (95% CI 66.65%–88.83%), respectively. Age, sex, tumor location, and side of the body on which the tumor was located had no effect on the detection rate of exosomal EGFRvIII transcript. EGFRvIII expression either in exosomes or tissue correlated with poor survival. CONCLUSIONS The authors established a serum-based method for detection of EGFRvIII in high-grade brain tumors that might serve as an optimal noninvasive method for diagnosing EGFRvIII -positive high-grade gliomas." @default.
• W2621189585 created "2017-06-09" @default.
• W2621189585 creator A5006982918 @default.
• W2621189585 creator A5011475873 @default.
• W2621189585 creator A5038463866 @default.
• W2621189585 creator A5040621259 @default.
• W2621189585 creator A5060138444 @default.
• W2621189585 creator A5061487300 @default.
• W2621189585 creator A5063242157 @default.
• W2621189585 creator A5065704978 @default.
• W2621189585 date "2018-04-01" @default.
• W2621189585 modified "2023-10-14" @default.
• W2621189585 title "Exosomes as a biomarker platform for detecting epidermal growth factor receptor–positive high-grade gliomas" @default.
• W2621189585 cites W1738003656 @default.
• W2621189585 cites W1910229223 @default.
• W2621189585 cites W1937665132 @default.
• W2621189585 cites W1991791143 @default.
• W2621189585 cites W2007499410 @default.
• W2621189585 cites W2010032031 @default.
• W2621189585 cites W2010956784 @default.
• W2621189585 cites W2011788217 @default.
• W2621189585 cites W2021227540 @default.
• W2621189585 cites W2023563217 @default.
• W2621189585 cites W2028119906 @default.
• W2621189585 cites W2030701238 @default.
• W2621189585 cites W2031470129 @default.
• W2621189585 cites W2039923138 @default.
• W2621189585 cites W2045699527 @default.
• W2621189585 cites W2055313665 @default.
• W2621189585 cites W2064876412 @default.
• W2621189585 cites W2070705072 @default.
• W2621189585 cites W2073618702 @default.
• W2621189585 cites W2073641341 @default.
• W2621189585 cites W2098259366 @default.
• W2621189585 cites W2100265701 @default.
• W2621189585 cites W2103744931 @default.
• W2621189585 cites W2114551767 @default.
• W2621189585 cites W2121354606 @default.
• W2621189585 cites W2122919112 @default.
• W2621189585 cites W2141569879 @default.
• W2621189585 cites W2148216778 @default.
• W2621189585 cites W2155401787 @default.
• W2621189585 cites W2157733223 @default.
• W2621189585 cites W2161289668 @default.
• W2621189585 cites W2226953621 @default.
• W2621189585 cites W2337269107 @default.
• W2621189585 cites W2366536035 @default.
• W2621189585 cites W2475109848 @default.
• W2621189585 doi "https://doi.org/10.3171/2016.11.jns161187" @default.
• W2621189585 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28574310" @default.
• W2621189585 hasPublicationYear "2018" @default.
• W2621189585 type Work @default.
• W2621189585 sameAs 2621189585 @default.
• W2621189585 citedByCount "72" @default.
• W2621189585 countsByYear W26211895852017 @default.
• W2621189585 countsByYear W26211895852018 @default.
• W2621189585 countsByYear W26211895852019 @default.
• W2621189585 countsByYear W26211895852020 @default.
• W2621189585 countsByYear W26211895852021 @default.
• W2621189585 countsByYear W26211895852022 @default.
• W2621189585 countsByYear W26211895852023 @default.
• W2621189585 crossrefType "journal-article" @default.
• W2621189585 hasAuthorship W2621189585A5006982918 @default.
• W2621189585 hasAuthorship W2621189585A5011475873 @default.
• W2621189585 hasAuthorship W2621189585A5038463866 @default.
• W2621189585 hasAuthorship W2621189585A5040621259 @default.
• W2621189585 hasAuthorship W2621189585A5060138444 @default.
• W2621189585 hasAuthorship W2621189585A5061487300 @default.
• W2621189585 hasAuthorship W2621189585A5063242157 @default.
• W2621189585 hasAuthorship W2621189585A5065704978 @default.
• W2621189585 hasBestOaLocation W26211895851 @default.
• W2621189585 hasConcept C104317684 @default.
• W2621189585 hasConcept C121608353 @default.
• W2621189585 hasConcept C126322002 @default.
• W2621189585 hasConcept C142724271 @default.
• W2621189585 hasConcept C145059251 @default.
• W2621189585 hasConcept C153911025 @default.
• W2621189585 hasConcept C170493617 @default.
• W2621189585 hasConcept C203014093 @default.
• W2621189585 hasConcept C204232928 @default.
• W2621189585 hasConcept C20518536 @default.
• W2621189585 hasConcept C2775934546 @default.
• W2621189585 hasConcept C2776362946 @default.
• W2621189585 hasConcept C2779438470 @default.
• W2621189585 hasConcept C2779529041 @default.
• W2621189585 hasConcept C2781197716 @default.
• W2621189585 hasConcept C2781261824 @default.
• W2621189585 hasConcept C49105822 @default.
• W2621189585 hasConcept C502942594 @default.
• W2621189585 hasConcept C553184892 @default.
• W2621189585 hasConcept C55493867 @default.
• W2621189585 hasConcept C71924100 @default.
• W2621189585 hasConcept C86803240 @default.
• W2621189585 hasConceptScore W2621189585C104317684 @default.
• W2621189585 hasConceptScore W2621189585C121608353 @default.
• W2621189585 hasConceptScore W2621189585C126322002 @default.
• W2621189585 hasConceptScore W2621189585C142724271 @default.
• W2621189585 hasConceptScore W2621189585C145059251 @default.

• next