FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2621196568> ?p ?o ?g. }

• W2621196568 abstract "BACKGROUND. Aortic stiffness (AS) is an independent predictor of cardiovascular events and is associated with hypertension (HTN) in aging and obesity however it is unclear whether HTN causes AS or AS could develop in advance of HTN. C57Bl/6J mice fed a diet rich in fat and sucrose (HFHS) develop obesity mimicking the metabolic syndrome. AIMS. We sought to determine: 1) whether AS occurs in HFHS-fed mice; 2) the relation between AS and HTN in such a model and 2) whether weight loss could improve AS and HTN in obese mice. METHODS. Pulse wave velocity (PWV) was measured by ultrasound as an in vivo index of arterial stiffness and confirmed invasively with high-fidelity pressure catheters. Blood pressure was measured by radiotelemetry in conscious mice. Weight loss was achieved by reversing mice to ND after 5 months of HFHS with bi-weekly assessments of metabolic and cardiovascular parameters. RESULTS. AS developed in HFHS-fed mice within 2 months (PWV from 2.3 ± 0.2 to 4.1 ± 0.5 m/s, n=6, mean ± SEM, p<0.05) and remained elevated up to 8 months (5.1 ± 0.5 m/s, n=10). Systolic and mean arterial pressures were significantly elevated after 6 months of HFHS (SBP: from 119.2 ± 1.8 to 140.4 ± 2.5 mmHg and MAP: from 106.9 ± 1.9 to 123 ± 1.6 mmHg; n=6). Within two months, when AS was fully developed, aortas from HFHS-fed mice had impaired endothelium-dependent relaxation and increased transglutaminase-2 activity, both in vitro indices of reduced NO bioactivity and ∼3-fold upregulation of pro-inflammatory cytokines TNFα, MCP-1 and MIP1α. Diet reversal induced a return to normal weight within 8 weeks accompanied by a 2-fold reduction in fat mass and hyperinsulinemia. PWV was significantly reduced from 5.3 ± 0.7 to 3.4 ± 0.4 m/s after reversal to ND and SBP and MAP were decreased to normal values (from 138.1 ± 3.7 to 124.2 ± 2.7 mmHg and from 121.2 ± 3.9 to 109.5 ± 3.4 mmHg, respectively). Atomic force measurements on aortic rings, an in vitro indicator of structural stiffness of the intima, was increased after HFHS (52 ± 4.8, n=7 vs 24 ± 2.8 kPa in ND, n=10) and significantly decreased after reversal to ND (30 ± 3.7 kPa, n=8). CONCLUSIONS. In a model of dietary obesity, arterial stiffness precedes the onset of hypertension and is reversed by normalization of the metabolic state achieved by weight loss." @default.
• W2621196568 created "2017-06-09" @default.
• W2621196568 creator A5005465891 @default.
• W2621196568 creator A5007545731 @default.
• W2621196568 creator A5023995071 @default.
• W2621196568 creator A5035287010 @default.
• W2621196568 creator A5036596541 @default.
• W2621196568 creator A5043840964 @default.
• W2621196568 creator A5048501504 @default.
• W2621196568 creator A5062114034 @default.
• W2621196568 creator A5066056970 @default.
• W2621196568 creator A5070992899 @default.
• W2621196568 creator A5076210364 @default.
• W2621196568 date "2013-09-01" @default.
• W2621196568 modified "2023-09-24" @default.
• W2621196568 title "Abstract 411: Arterial Stiffening Precedes Systolic Hypertension in Diet-induced Obese Mice and Is Reversed by Weight Loss" @default.
• W2621196568 doi "https://doi.org/10.1161/hyp.62.suppl_1.a411" @default.
• W2621196568 hasPublicationYear "2013" @default.
• W2621196568 type Work @default.
• W2621196568 sameAs 2621196568 @default.
• W2621196568 citedByCount "0" @default.
• W2621196568 crossrefType "journal-article" @default.
• W2621196568 hasAuthorship W2621196568A5005465891 @default.
• W2621196568 hasAuthorship W2621196568A5007545731 @default.
• W2621196568 hasAuthorship W2621196568A5023995071 @default.
• W2621196568 hasAuthorship W2621196568A5035287010 @default.
• W2621196568 hasAuthorship W2621196568A5036596541 @default.
• W2621196568 hasAuthorship W2621196568A5043840964 @default.
• W2621196568 hasAuthorship W2621196568A5048501504 @default.
• W2621196568 hasAuthorship W2621196568A5062114034 @default.
• W2621196568 hasAuthorship W2621196568A5066056970 @default.
• W2621196568 hasAuthorship W2621196568A5070992899 @default.
• W2621196568 hasAuthorship W2621196568A5076210364 @default.
• W2621196568 hasConcept C126322002 @default.
• W2621196568 hasConcept C134018914 @default.
• W2621196568 hasConcept C164705383 @default.
• W2621196568 hasConcept C17140001 @default.
• W2621196568 hasConcept C2775850156 @default.
• W2621196568 hasConcept C2776452961 @default.
• W2621196568 hasConcept C2777953023 @default.
• W2621196568 hasConcept C2778319312 @default.
• W2621196568 hasConcept C2780578515 @default.
• W2621196568 hasConcept C511355011 @default.
• W2621196568 hasConcept C544821477 @default.
• W2621196568 hasConcept C71924100 @default.
• W2621196568 hasConcept C84393581 @default.
• W2621196568 hasConceptScore W2621196568C126322002 @default.
• W2621196568 hasConceptScore W2621196568C134018914 @default.
• W2621196568 hasConceptScore W2621196568C164705383 @default.
• W2621196568 hasConceptScore W2621196568C17140001 @default.
• W2621196568 hasConceptScore W2621196568C2775850156 @default.
• W2621196568 hasConceptScore W2621196568C2776452961 @default.
• W2621196568 hasConceptScore W2621196568C2777953023 @default.
• W2621196568 hasConceptScore W2621196568C2778319312 @default.
• W2621196568 hasConceptScore W2621196568C2780578515 @default.
• W2621196568 hasConceptScore W2621196568C511355011 @default.
• W2621196568 hasConceptScore W2621196568C544821477 @default.
• W2621196568 hasConceptScore W2621196568C71924100 @default.
• W2621196568 hasConceptScore W2621196568C84393581 @default.
• W2621196568 hasIssue "suppl_1" @default.
• W2621196568 hasLocation W26211965681 @default.
• W2621196568 hasOpenAccess W2621196568 @default.
• W2621196568 hasPrimaryLocation W26211965681 @default.
• W2621196568 hasRelatedWork W1974238827 @default.
• W2621196568 hasRelatedWork W1977617928 @default.
• W2621196568 hasRelatedWork W1998782725 @default.
• W2621196568 hasRelatedWork W2038464101 @default.
• W2621196568 hasRelatedWork W2044964708 @default.
• W2621196568 hasRelatedWork W2129380198 @default.
• W2621196568 hasRelatedWork W2144708423 @default.
• W2621196568 hasRelatedWork W2164667396 @default.
• W2621196568 hasRelatedWork W2291315650 @default.
• W2621196568 hasRelatedWork W2291390788 @default.
• W2621196568 hasRelatedWork W2470575000 @default.
• W2621196568 hasRelatedWork W2553127428 @default.
• W2621196568 hasRelatedWork W2586886436 @default.
• W2621196568 hasRelatedWork W2904455220 @default.
• W2621196568 hasRelatedWork W2995140472 @default.
• W2621196568 hasRelatedWork W3012433487 @default.
• W2621196568 hasRelatedWork W3162814218 @default.
• W2621196568 hasRelatedWork W3166315605 @default.
• W2621196568 hasRelatedWork W3171297891 @default.
• W2621196568 hasRelatedWork W3192141866 @default.
• W2621196568 hasVolume "62" @default.
• W2621196568 isParatext "false" @default.
• W2621196568 isRetracted "false" @default.
• W2621196568 magId "2621196568" @default.
• W2621196568 workType "article" @default.