Matches in SemOpenAlex for { <https://semopenalex.org/work/W2621270663> ?p ?o ?g. }
- W2621270663 endingPage "27" @default.
- W2621270663 startingPage "11" @default.
- W2621270663 abstract "Cytochrome P450 (CYP450) is a superfamily of metabolizing enzymes which play a major role in the biotransformation of xenobiotics, i.e. drug, foods,, chemicals, pollutants, and endogenous compounds. The activity of CYP450 is one of the most influent factors on the drug-pharmacokinetics. CYP2D6 is one of CYP450 isoforms which takes responsibility in the metabolism of varieties clinically used drugs that usually have narrow therapeutic index such as antidepressants and anti-hypertensives. The activity of CYP2D6 is affected by both exogenous and endogenous influences, including genetic variation, epigenetic variation, and concurrently used drugs. Genetic variation of CYP2D6 genes is either hereditary or acquired mutation. The variation of CYP2D6 activity due to genetic mutation is referred to polymorphism. Polymorphism of CYP2D6 has been reported to associate with failure of pharmacotherapy and risk of adverse effects. Small rodents are often employed for the pharmacokinetic study by using the human orthologue as the determinant, however, the difference of human CYP2D6 and small rodent Cyp2d are remarkable. Hence, this review focuses on significance of human CYP2D6 , its rodent human orthologue, CYP2D6 genetic variation and polymorphism, and some clinical impacts of CYP2D6 polymorphism." @default.
- W2621270663 created "2017-06-09" @default.
- W2621270663 creator A5001447126 @default.
- W2621270663 creator A5029515835 @default.
- W2621270663 date "2017-04-07" @default.
- W2621270663 modified "2023-09-28" @default.
- W2621270663 title "Significance of CYP2D Polymorphism" @default.
- W2621270663 cites W1930341630 @default.
- W2621270663 cites W1979268079 @default.
- W2621270663 cites W1979786364 @default.
- W2621270663 cites W1981598340 @default.
- W2621270663 cites W1981792138 @default.
- W2621270663 cites W1985511816 @default.
- W2621270663 cites W1993573305 @default.
- W2621270663 cites W1993905498 @default.
- W2621270663 cites W2002192743 @default.
- W2621270663 cites W2002809107 @default.
- W2621270663 cites W2014670337 @default.
- W2621270663 cites W2016599293 @default.
- W2621270663 cites W2024520583 @default.
- W2621270663 cites W2024650807 @default.
- W2621270663 cites W2024653308 @default.
- W2621270663 cites W2044594845 @default.
- W2621270663 cites W2047288490 @default.
- W2621270663 cites W2060062181 @default.
- W2621270663 cites W2063320172 @default.
- W2621270663 cites W2067763594 @default.
- W2621270663 cites W2067992637 @default.
- W2621270663 cites W2073363614 @default.
- W2621270663 cites W2073665078 @default.
- W2621270663 cites W2074211250 @default.
- W2621270663 cites W2074266529 @default.
- W2621270663 cites W2077287304 @default.
- W2621270663 cites W2085387111 @default.
- W2621270663 cites W2085535677 @default.
- W2621270663 cites W2086158492 @default.
- W2621270663 cites W2086206243 @default.
- W2621270663 cites W2086775461 @default.
- W2621270663 cites W2087460065 @default.
- W2621270663 cites W209314204 @default.
- W2621270663 cites W2100013234 @default.
- W2621270663 cites W2137721915 @default.
- W2621270663 cites W2167244495 @default.
- W2621270663 cites W2169086666 @default.
- W2621270663 cites W2225070830 @default.
- W2621270663 hasPublicationYear "2017" @default.
- W2621270663 type Work @default.
- W2621270663 sameAs 2621270663 @default.
- W2621270663 citedByCount "0" @default.
- W2621270663 crossrefType "journal-article" @default.
- W2621270663 hasAuthorship W2621270663A5001447126 @default.
- W2621270663 hasAuthorship W2621270663A5029515835 @default.
- W2621270663 hasConcept C104317684 @default.
- W2621270663 hasConcept C115448650 @default.
- W2621270663 hasConcept C135763542 @default.
- W2621270663 hasConcept C149737253 @default.
- W2621270663 hasConcept C170734499 @default.
- W2621270663 hasConcept C181199279 @default.
- W2621270663 hasConcept C33664856 @default.
- W2621270663 hasConcept C526171541 @default.
- W2621270663 hasConcept C54355233 @default.
- W2621270663 hasConcept C55493867 @default.
- W2621270663 hasConcept C68873052 @default.
- W2621270663 hasConcept C86803240 @default.
- W2621270663 hasConcept C98274493 @default.
- W2621270663 hasConceptScore W2621270663C104317684 @default.
- W2621270663 hasConceptScore W2621270663C115448650 @default.
- W2621270663 hasConceptScore W2621270663C135763542 @default.
- W2621270663 hasConceptScore W2621270663C149737253 @default.
- W2621270663 hasConceptScore W2621270663C170734499 @default.
- W2621270663 hasConceptScore W2621270663C181199279 @default.
- W2621270663 hasConceptScore W2621270663C33664856 @default.
- W2621270663 hasConceptScore W2621270663C526171541 @default.
- W2621270663 hasConceptScore W2621270663C54355233 @default.
- W2621270663 hasConceptScore W2621270663C55493867 @default.
- W2621270663 hasConceptScore W2621270663C68873052 @default.
- W2621270663 hasConceptScore W2621270663C86803240 @default.
- W2621270663 hasConceptScore W2621270663C98274493 @default.
- W2621270663 hasIssue "1" @default.
- W2621270663 hasLocation W26212706631 @default.
- W2621270663 hasOpenAccess W2621270663 @default.
- W2621270663 hasPrimaryLocation W26212706631 @default.
- W2621270663 hasRelatedWork W1971721185 @default.
- W2621270663 hasRelatedWork W1972086924 @default.
- W2621270663 hasRelatedWork W2012812808 @default.
- W2621270663 hasRelatedWork W2041694332 @default.
- W2621270663 hasRelatedWork W2041917695 @default.
- W2621270663 hasRelatedWork W2048806256 @default.
- W2621270663 hasRelatedWork W2138332753 @default.
- W2621270663 hasRelatedWork W2315820523 @default.
- W2621270663 hasRelatedWork W2360372628 @default.
- W2621270663 hasRelatedWork W2364447186 @default.
- W2621270663 hasRelatedWork W2374222794 @default.
- W2621270663 hasRelatedWork W2377620846 @default.
- W2621270663 hasRelatedWork W2416013658 @default.
- W2621270663 hasRelatedWork W2520142472 @default.
- W2621270663 hasRelatedWork W2540748184 @default.
- W2621270663 hasRelatedWork W2790716134 @default.