FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2621386780> ?p ?o ?g. }

• W2621386780 endingPage "77" @default.
• W2621386780 startingPage "70" @default.
• W2621386780 abstract "Neuronal excitability controls the expression of a variety of genes and proteins and therefore regulates neurite outgrowth and synapse formation, fundamental physiological processes controlling learning and memory. Scorpion venom contains many neurotoxins which alter ion channel activities that influence neuronal excitability. In this study, a novel scorpion peptide termed BmK NT2 was purified from venom of Chinese scorpion Buthus martensii Karsch by combining mass spectrum mapping and intracellular Ca2+ concentration measurement in primary cultured neocortical neurons. Electrophysiological experiments demonstrated that BmK NT2 concentration-dependently delayed inactivation of voltage-gated sodium channels (VGSCs) with an EC50 value of 0.91 μM, and shifted the steady-state activation and inactivation of VGSCs to hyperpolarized direction. The effects of BmK NT2 on electrophysiological characteristics of VGSCs were similar to that of α-scorpion toxins. BmK NT2 altered Ca2+ dynamics and increased phosphorylation of extracellular-regulated protein kinases (ERK) 1/2 and cAMP-response element binding (CREB) proteins, which were eliminated by the VGSC blocker, tetrodotoxin. These data demonstrate that BmK NT2 is a novel VGSC α-scorpion toxin which is sufficient to increase the phosphorylation of ERK1/2 and CREB proteins, suggesting that modulation of VGSC function by α-scorpion toxin exerts neurotrophic effect in primary cultured neocortical neurons." @default.
• W2621386780 created "2017-06-09" @default.
• W2621386780 creator A5019456473 @default.
• W2621386780 creator A5020248771 @default.
• W2621386780 creator A5026071162 @default.
• W2621386780 creator A5028513477 @default.
• W2621386780 creator A5030707354 @default.
• W2621386780 creator A5053447705 @default.
• W2621386780 creator A5077816945 @default.
• W2621386780 date "2017-11-01" @default.
• W2621386780 modified "2023-10-01" @default.
• W2621386780 title "Activation of sodium channel by a novel α-scorpion toxin, BmK NT2, stimulates ERK1/2 and CERB phosphorylation through a Ca2+ dependent pathway in neocortical neurons" @default.
• W2621386780 cites W1485916201 @default.
• W2621386780 cites W1598578622 @default.
• W2621386780 cites W1650401181 @default.
• W2621386780 cites W1963535712 @default.
• W2621386780 cites W1974743418 @default.
• W2621386780 cites W1974937986 @default.
• W2621386780 cites W1992209399 @default.
• W2621386780 cites W1996362740 @default.
• W2621386780 cites W1998977808 @default.
• W2621386780 cites W2002069093 @default.
• W2621386780 cites W2016999300 @default.
• W2621386780 cites W2017721112 @default.
• W2621386780 cites W2019203795 @default.
• W2621386780 cites W2019671071 @default.
• W2621386780 cites W2026372526 @default.
• W2621386780 cites W2035977066 @default.
• W2621386780 cites W2037212965 @default.
• W2621386780 cites W2053307645 @default.
• W2621386780 cites W2054706865 @default.
• W2621386780 cites W2059743066 @default.
• W2621386780 cites W2068315357 @default.
• W2621386780 cites W2071952797 @default.
• W2621386780 cites W2073188416 @default.
• W2621386780 cites W2084002376 @default.
• W2621386780 cites W2088485943 @default.
• W2621386780 cites W2099344620 @default.
• W2621386780 cites W2099814157 @default.
• W2621386780 cites W2119857062 @default.
• W2621386780 cites W2125402042 @default.
• W2621386780 cites W2137015675 @default.
• W2621386780 cites W2147101888 @default.
• W2621386780 cites W2148574990 @default.
• W2621386780 cites W2150486823 @default.
• W2621386780 cites W2155586061 @default.
• W2621386780 cites W2166353621 @default.
• W2621386780 cites W2306273607 @default.
• W2621386780 cites W2429108044 @default.
• W2621386780 cites W4255760236 @default.
• W2621386780 doi "https://doi.org/10.1016/j.ijbiomac.2017.05.163" @default.
• W2621386780 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28591591" @default.
• W2621386780 hasPublicationYear "2017" @default.
• W2621386780 type Work @default.
• W2621386780 sameAs 2621386780 @default.
• W2621386780 citedByCount "10" @default.
• W2621386780 countsByYear W26213867802019 @default.
• W2621386780 countsByYear W26213867802020 @default.
• W2621386780 countsByYear W26213867802021 @default.
• W2621386780 countsByYear W26213867802022 @default.
• W2621386780 crossrefType "journal-article" @default.
• W2621386780 hasAuthorship W2621386780A5019456473 @default.
• W2621386780 hasAuthorship W2621386780A5020248771 @default.
• W2621386780 hasAuthorship W2621386780A5026071162 @default.
• W2621386780 hasAuthorship W2621386780A5028513477 @default.
• W2621386780 hasAuthorship W2621386780A5030707354 @default.
• W2621386780 hasAuthorship W2621386780A5053447705 @default.
• W2621386780 hasAuthorship W2621386780A5077816945 @default.
• W2621386780 hasConcept C104317684 @default.
• W2621386780 hasConcept C113246987 @default.
• W2621386780 hasConcept C11960822 @default.
• W2621386780 hasConcept C12554922 @default.
• W2621386780 hasConcept C130316041 @default.
• W2621386780 hasConcept C148785051 @default.
• W2621386780 hasConcept C1629964 @default.
• W2621386780 hasConcept C170493617 @default.
• W2621386780 hasConcept C178790620 @default.
• W2621386780 hasConcept C185592680 @default.
• W2621386780 hasConcept C202751555 @default.
• W2621386780 hasConcept C2776676993 @default.
• W2621386780 hasConcept C2776741303 @default.
• W2621386780 hasConcept C2776986425 @default.
• W2621386780 hasConcept C2779448229 @default.
• W2621386780 hasConcept C41625074 @default.
• W2621386780 hasConcept C50254741 @default.
• W2621386780 hasConcept C50493954 @default.
• W2621386780 hasConcept C50952357 @default.
• W2621386780 hasConcept C537181965 @default.
• W2621386780 hasConcept C55493867 @default.
• W2621386780 hasConcept C57074206 @default.
• W2621386780 hasConcept C86339819 @default.
• W2621386780 hasConcept C86803240 @default.
• W2621386780 hasConcept C95444343 @default.
• W2621386780 hasConceptScore W2621386780C104317684 @default.
• W2621386780 hasConceptScore W2621386780C113246987 @default.
• W2621386780 hasConceptScore W2621386780C11960822 @default.
• W2621386780 hasConceptScore W2621386780C12554922 @default.
• W2621386780 hasConceptScore W2621386780C130316041 @default.

• next