FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2621437524> ?p ?o ?g. }

• W2621437524 endingPage "41" @default.
• W2621437524 startingPage "32" @default.
• W2621437524 abstract "Increasing pressure on product quality and quantity pushes solutions of process control to be a central issue in pharmaceutical bioprocesses. Especially online biomass estimation, and further control of the specific growth rate are of central importance because they describe the catalyst of the reaction. For penicillin producing bioprocesses with filamentous microorganisms, this was underlined by recent findings describing the influence of the specific growth rate on the specific production rate. Hence, the specific growth rate needs to be controlled on a certain level to achieve high productivity. In this study, we developed a control strategy for the specific growth rate based on online estimation of viable biomass via dielectric spectroscopy. The method was verified using an at-line staining method for viability measurement. The online viable biomass estimation is applicable in the growth and decline phase, coping with physiological and morphological changes of filamentous fungi. Furthermore, the control strategy adapts to changing biomass yields, which is a big issue in the bioprocess for penicillin production applied in this study. Two application runs were conducted, yielding in proper online viable biomass estimation and control of the specific growth rate at a constant level of 0.012 h−1. We achieved biomass predictions with an average error of 1.5 g/l over the whole fed-batch process. In the decline phase, the control of specific growth rates was not possible due to physiological constrains. However, in the growth phase, a total specific growth rate of 0.013 h−1 was achieved, which met the pre-defined acceptance criterion for this method. The method is thus ready for viable biomass estimation in the growth and in the decline phase of the penicillin production process. Furthermore, the method is applicable to control the specific growth rate during the growth phase." @default.
• W2621437524 created "2017-06-15" @default.
• W2621437524 creator A5000823718 @default.
• W2621437524 creator A5014729591 @default.
• W2621437524 creator A5015875801 @default.
• W2621437524 creator A5020297199 @default.
• W2621437524 creator A5027617880 @default.
• W2621437524 creator A5036866790 @default.
• W2621437524 creator A5039608322 @default.
• W2621437524 creator A5055332747 @default.
• W2621437524 date "2017-11-01" @default.
• W2621437524 modified "2023-10-03" @default.
• W2621437524 title "Controlling the specific growth rate via biomass trend regulation in filamentous fungi bioprocesses" @default.
• W2621437524 cites W1964735120 @default.
• W2621437524 cites W1972207956 @default.
• W2621437524 cites W1977277757 @default.
• W2621437524 cites W1979923568 @default.
• W2621437524 cites W1980340867 @default.
• W2621437524 cites W1986655674 @default.
• W2621437524 cites W1997278605 @default.
• W2621437524 cites W1999367645 @default.
• W2621437524 cites W2022788035 @default.
• W2621437524 cites W2034253734 @default.
• W2621437524 cites W2050350037 @default.
• W2621437524 cites W2050833777 @default.
• W2621437524 cites W2055138926 @default.
• W2621437524 cites W2061106634 @default.
• W2621437524 cites W2065124384 @default.
• W2621437524 cites W2066328967 @default.
• W2621437524 cites W2067780259 @default.
• W2621437524 cites W2075128186 @default.
• W2621437524 cites W2079203780 @default.
• W2621437524 cites W2083551286 @default.
• W2621437524 cites W2091670774 @default.
• W2621437524 cites W2093136988 @default.
• W2621437524 cites W2106436428 @default.
• W2621437524 cites W2114759805 @default.
• W2621437524 cites W2126383085 @default.
• W2621437524 cites W2135236730 @default.
• W2621437524 cites W2155967620 @default.
• W2621437524 cites W2306759795 @default.
• W2621437524 cites W2431613453 @default.
• W2621437524 cites W2518273921 @default.
• W2621437524 cites W4234446168 @default.
• W2621437524 cites W66648161 @default.
• W2621437524 doi "https://doi.org/10.1016/j.ces.2017.06.020" @default.
• W2621437524 hasPublicationYear "2017" @default.
• W2621437524 type Work @default.
• W2621437524 sameAs 2621437524 @default.
• W2621437524 citedByCount "22" @default.
• W2621437524 countsByYear W26214375242018 @default.
• W2621437524 countsByYear W26214375242019 @default.
• W2621437524 countsByYear W26214375242020 @default.
• W2621437524 countsByYear W26214375242021 @default.
• W2621437524 countsByYear W26214375242022 @default.
• W2621437524 countsByYear W26214375242023 @default.
• W2621437524 crossrefType "journal-article" @default.
• W2621437524 hasAuthorship W2621437524A5000823718 @default.
• W2621437524 hasAuthorship W2621437524A5014729591 @default.
• W2621437524 hasAuthorship W2621437524A5015875801 @default.
• W2621437524 hasAuthorship W2621437524A5020297199 @default.
• W2621437524 hasAuthorship W2621437524A5027617880 @default.
• W2621437524 hasAuthorship W2621437524A5036866790 @default.
• W2621437524 hasAuthorship W2621437524A5039608322 @default.
• W2621437524 hasAuthorship W2621437524A5055332747 @default.
• W2621437524 hasConcept C115540264 @default.
• W2621437524 hasConcept C127413603 @default.
• W2621437524 hasConcept C139719470 @default.
• W2621437524 hasConcept C150903083 @default.
• W2621437524 hasConcept C151730666 @default.
• W2621437524 hasConcept C162324750 @default.
• W2621437524 hasConcept C17741926 @default.
• W2621437524 hasConcept C178144697 @default.
• W2621437524 hasConcept C183696295 @default.
• W2621437524 hasConcept C18903297 @default.
• W2621437524 hasConcept C204983608 @default.
• W2621437524 hasConcept C21880701 @default.
• W2621437524 hasConcept C2524010 @default.
• W2621437524 hasConcept C2778312390 @default.
• W2621437524 hasConcept C33923547 @default.
• W2621437524 hasConcept C39432304 @default.
• W2621437524 hasConcept C4916135 @default.
• W2621437524 hasConcept C523546767 @default.
• W2621437524 hasConcept C528095902 @default.
• W2621437524 hasConcept C54355233 @default.
• W2621437524 hasConcept C86803240 @default.
• W2621437524 hasConceptScore W2621437524C115540264 @default.
• W2621437524 hasConceptScore W2621437524C127413603 @default.
• W2621437524 hasConceptScore W2621437524C139719470 @default.
• W2621437524 hasConceptScore W2621437524C150903083 @default.
• W2621437524 hasConceptScore W2621437524C151730666 @default.
• W2621437524 hasConceptScore W2621437524C162324750 @default.
• W2621437524 hasConceptScore W2621437524C17741926 @default.
• W2621437524 hasConceptScore W2621437524C178144697 @default.
• W2621437524 hasConceptScore W2621437524C183696295 @default.
• W2621437524 hasConceptScore W2621437524C18903297 @default.
• W2621437524 hasConceptScore W2621437524C204983608 @default.
• W2621437524 hasConceptScore W2621437524C21880701 @default.

• next