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• W2621458579 abstract "Background: Childhood trauma (CT) and cannabis use are both a environmental and modifier risk factors for schizophrenia. However, a little is known about how they interact in schizophrenia. We examined a the main effect of each of these two environmental factors on the a clinical expression of the disease using a large set of variables, and a we tested whether and how cannabis and CT interact to influence the a course and the presentation of the illness. a Methods: A sample of 366 patients who met the DSM-IV-TR criteria for a schizophrenia was recruited through the FACE-SCZ (Fondamental Advanced a Centre of Expertise - Schizophrenia) network. Patients completed a large a standardized clinical evaluation including Structured Clinical Interview a for DSM Disorders-I (SCID-I), Positive and Negative Symptoms Scale a (PANSS), Columbia-Suicide Severity Rating Scale (C-SSRS), Global a Assessment of Functioning (GAF), Short-Quality of Life-18 (S-QoL-18), a and Medication Adherence Rating Scale (MARS). We assessed CT with the a Childhood Trauma Questionnaire and cannabis status with SCID-I. a Results: CT significantly predicted the number of hospitalizations, GAF, a and S-QoL-18 scores, as well as the PANSS total, positive, excitement, a and emotional distress scores. Cannabis use disorders significantly a predicted age of onset, and MARS. There was no significant interaction a between CT and cannabis use disorders. However, we found evidence of a a correlation between these two risk factors. a Conclusions: CT and cannabis both have differential deleterious effects a on clinical and functional outcomes in patients with schizophrenia. Our a results highlight the need to systematically assess the presence of a these risk factors and adopt suitable therapeutic interventions. (C) a 2016 Elsevier B.V. All rights reserved." @default.
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• W2621458579 date "2016-01-01" @default.
• W2621458579 modified "2023-09-22" @default.
• W2621458579 title "Differential effects of childhood trauma and cannabis use disorders in ă patients suffering from schizophrenia" @default.
• W2621458579 hasPublicationYear "2016" @default.
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