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- W2621480624 endingPage "67" @default.
- W2621480624 startingPage "47" @default.
- W2621480624 abstract "The presence of supernumerary centrosomes is a hallmark of human tumours. Recent work in animal models suggests that extra centrosomes are not just bystanders in cancer but can accelerate tumourigenesis in the absence of the tumour suppressor p53. Centrosome amplification could indeed actively participate in tumour progression through the induction of chromosome instability, disruption of tissue architecture and promoting cell invasion. Paradoxically, however, centrosome amplification is rather poorly tolerated in normal cells and there are several hurdles cells need to overcome in order to efficiently proliferate in the presence of extra centrosomes. Here, we review the adaptation mechanisms that allow cells to efficiently divide in the presence of extra centrosomes and how these could be exploited to develop selective cancer therapies." @default.
- W2621480624 created "2017-06-15" @default.
- W2621480624 creator A5068852417 @default.
- W2621480624 creator A5071836580 @default.
- W2621480624 date "2017-01-01" @default.
- W2621480624 modified "2023-09-26" @default.
- W2621480624 title "Dividing with Extra Centrosomes: A Double Edged Sword for Cancer Cells" @default.
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