FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2621487800> ?p ?o ?g. }

• W2621487800 endingPage "244" @default.
• W2621487800 startingPage "238" @default.
• W2621487800 abstract "Type 2 diabetes is a leading cause of cardiovascular disease ( CVD ). Observational studies have consistently shown an association between glycaemic level and risk of major adverse cardiovascular events ( MACE ); however, intervention studies have provided limited evidence supporting a reduction in the cardiovascular burden of diabetes through intensive glucose control. In the present review, we aimed to examine the concept of cumulative glycaemic exposure with regard to protection against CVD in diabetes. We address how we can move from a binary approach in trials, to a more quantitative approach based on differences in cumulative glycaemic exposure. We plotted the association between differing glycaemic exposures between study arms and the hazard ratio for MACE in randomized controls trials comparing intensive with conventional glycaemic control in type 2 diabetes. We found a strikingly strong correlation between differential exposure and cardiovascular risk reduction. Similar results were obtained for trials comparing antidiabetes drugs with placebo. The results suggest that a minimum study duration and a minimum gain in glycated haemoglobin ( HbA1c ) reduction are necessary to drive a relevant risk reduction in CVD risk, and we provide a quantitative perspective in that respect. The present analysis underlines that the duration of the intensification of glycemic control, and the amplitude of the resulting reduction in HbA1c , are important notions for clinical decision‐making." @default.
• W2621487800 created "2017-06-15" @default.
• W2621487800 creator A5038737554 @default.
• W2621487800 creator A5057869899 @default.
• W2621487800 creator A5063045773 @default.
• W2621487800 creator A5063859581 @default.
• W2621487800 creator A5088350286 @default.
• W2621487800 date "2017-07-25" @default.
• W2621487800 modified "2023-10-18" @default.
• W2621487800 title "Prevention of cardiovascular disease through reduction of glycaemic exposure in type 2 diabetes: <scp>A</scp> perspective on glucose‐lowering interventions" @default.
• W2621487800 cites W1526927233 @default.
• W2621487800 cites W172609984 @default.
• W2621487800 cites W1752045965 @default.
• W2621487800 cites W1933889113 @default.
• W2621487800 cites W1957007052 @default.
• W2621487800 cites W1974180544 @default.
• W2621487800 cites W1975663485 @default.
• W2621487800 cites W1983269691 @default.
• W2621487800 cites W2006804028 @default.
• W2621487800 cites W2007374852 @default.
• W2621487800 cites W2034721926 @default.
• W2621487800 cites W2064130493 @default.
• W2621487800 cites W2076573528 @default.
• W2621487800 cites W2095409509 @default.
• W2621487800 cites W2097995302 @default.
• W2621487800 cites W2106046752 @default.
• W2621487800 cites W2110664743 @default.
• W2621487800 cites W2118828771 @default.
• W2621487800 cites W2123212032 @default.
• W2621487800 cites W2123946565 @default.
• W2621487800 cites W2126919962 @default.
• W2621487800 cites W2127854619 @default.
• W2621487800 cites W2131490500 @default.
• W2621487800 cites W2142830692 @default.
• W2621487800 cites W2143094951 @default.
• W2621487800 cites W2144125787 @default.
• W2621487800 cites W2145730981 @default.
• W2621487800 cites W2145781386 @default.
• W2621487800 cites W2146264128 @default.
• W2621487800 cites W2146392529 @default.
• W2621487800 cites W2153170671 @default.
• W2621487800 cites W2158666727 @default.
• W2621487800 cites W2159969745 @default.
• W2621487800 cites W2161984474 @default.
• W2621487800 cites W2166212677 @default.
• W2621487800 cites W2169226612 @default.
• W2621487800 cites W2171294019 @default.
• W2621487800 cites W2282578582 @default.
• W2621487800 cites W2371318472 @default.
• W2621487800 cites W2425644022 @default.
• W2621487800 cites W2514445958 @default.
• W2621487800 cites W2519510391 @default.
• W2621487800 cites W2769264260 @default.
• W2621487800 cites W72392028 @default.
• W2621487800 doi "https://doi.org/10.1111/dom.13033" @default.
• W2621487800 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28597588" @default.
• W2621487800 hasPublicationYear "2017" @default.
• W2621487800 type Work @default.
• W2621487800 sameAs 2621487800 @default.
• W2621487800 citedByCount "49" @default.
• W2621487800 countsByYear W26214878002017 @default.
• W2621487800 countsByYear W26214878002018 @default.
• W2621487800 countsByYear W26214878002019 @default.
• W2621487800 countsByYear W26214878002020 @default.
• W2621487800 countsByYear W26214878002021 @default.
• W2621487800 countsByYear W26214878002022 @default.
• W2621487800 countsByYear W26214878002023 @default.
• W2621487800 crossrefType "journal-article" @default.
• W2621487800 hasAuthorship W2621487800A5038737554 @default.
• W2621487800 hasAuthorship W2621487800A5057869899 @default.
• W2621487800 hasAuthorship W2621487800A5063045773 @default.
• W2621487800 hasAuthorship W2621487800A5063859581 @default.
• W2621487800 hasAuthorship W2621487800A5088350286 @default.
• W2621487800 hasConcept C126322002 @default.
• W2621487800 hasConcept C134018914 @default.
• W2621487800 hasConcept C142724271 @default.
• W2621487800 hasConcept C168563851 @default.
• W2621487800 hasConcept C177713679 @default.
• W2621487800 hasConcept C204787440 @default.
• W2621487800 hasConcept C207103383 @default.
• W2621487800 hasConcept C23131810 @default.
• W2621487800 hasConcept C27081682 @default.
• W2621487800 hasConcept C2777180221 @default.
• W2621487800 hasConcept C2778848681 @default.
• W2621487800 hasConcept C2779134260 @default.
• W2621487800 hasConcept C2780473172 @default.
• W2621487800 hasConcept C2780739214 @default.
• W2621487800 hasConcept C2910068830 @default.
• W2621487800 hasConcept C44249647 @default.
• W2621487800 hasConcept C45393284 @default.
• W2621487800 hasConcept C500558357 @default.
• W2621487800 hasConcept C555293320 @default.
• W2621487800 hasConcept C71924100 @default.
• W2621487800 hasConceptScore W2621487800C126322002 @default.
• W2621487800 hasConceptScore W2621487800C134018914 @default.
• W2621487800 hasConceptScore W2621487800C142724271 @default.
• W2621487800 hasConceptScore W2621487800C168563851 @default.
• W2621487800 hasConceptScore W2621487800C177713679 @default.

• next