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- W2621568130 abstract "Abstract A series of glycosyl-substituted 1,3,4-oxadiazoles were synthesized by cyclization of glycosyl-acylthiosemicarbazides via a base-catalyzed reaction. The starting glycosyl-acylthiosemicarbazide derivatives were obtained by the reaction of glycosyl isothiocyanate with various hydrazides. The acetylcholinesterase (AChE) inhibitory activities of the products were tested by Ellman’s method. The most active compounds were subsequently evaluated for the 50% inhibitory concentration (IC 50 ) values. N -(1,3,4,6-tetra- O -benzyl-2-deoxy- β -D-glucopyranosyl)-5-(4-fluorophenyl)-1,3,4-oxadiazole-2-amine ( 6i ) possesses the best AChE -inhibition activity with an IC 50 of 1.61±0.34 μ m ." @default.
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- W2621568130 date "2018-11-13" @default.
- W2621568130 modified "2023-10-16" @default.
- W2621568130 title "Synthesis and bioactivity of novel C2-glycosyl oxadiazole derivatives as acetylcholinesterase inhibitors" @default.
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- W2621568130 doi "https://doi.org/10.1515/hc-2018-0166" @default.
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