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- W2621647923 abstract "5-((1, 3-Dioxoisoindolin-2-yl)methyl-2-hydroxybenzohydrazide ( 1 ) undergoes facile condensation with aromatic aldehydes to afford the corresponding N '-substituted-phenyl-5-((1,3-dioxoisoindolin-2-yl) methyl)-2-hydroxybenzohydrazide ( 2a-h ) in good yields. Cyclocondensation of compounds ( 2a-h ) with thioglycolic acid yields 5-((1,3-dioxoisoindolin-2-yl) methyl)-2-hydroxy- N -(4-oxo-2-substituted phenylthiazolidin-3-yl)benzamide ( 3a-h ). These ( 3a-h ) compounds were further reacted with benzaldehyde in the presence of sodium ethanolate affords, (Z) – N -(5-benzylidene-4-oxo-2-substituted phenyl-thiazolidin-3-yl)-5-((1,3-dioxoisoindolin-2-yl)methyl)-2-hydroxybenzamdie( 4a-h ). The structures of these compounds were established on the basis of analytical and spectral data. All the newly synthesized compounds were evaluated for their antibacterial and antifungal activities." @default.
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- W2621647923 date "2010-01-01" @default.
- W2621647923 modified "2023-10-16" @default.
- W2621647923 title "Synthesis and Biological Activity of (Z) –n-(5-Benzylidene-4-oxo-2-substituted- phenylthiazolidin-3-yl)-5-((1, 3-dioxoisoindolin-2-yl)methyl)-2-hydroxybenzamide" @default.
- W2621647923 doi "https://doi.org/10.1155/2010/586984" @default.
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