FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2621731562> ?p ?o ?g. }

• W2621731562 abstract "The recurrent Coxsackievirus B3 (CVB3) infection is the most important cause of intractable myocarditis which often leads to chronic myocarditis and even dilated cardiomyopathy. Therefore, enhanced DNA vaccines capable of memory CD8 T cells are essential for long-lasting immunological protection against CVB3 infection. In this study, absent in melanoma 2 (AIM2) was used as an adjuvant to enhance the induction of memory CD8 T cells elicited by VP1 (viral capsid protein 1) vaccine. Mice were intramuscularly injected with 50 μg AIM2 plasmid and equal amount of VP1 plasmid (pAIM2/pVP1) vaccine 4 times at 2 week-intervals. We observed that the protection of pAIM2/pVP1 vaccine against CVB3 challenge was evidenced by significantly improved cardiac function, reduced myocardial injuries, and increased survival rate when compared with immunization with pVP1. Co-immunization with pAIM2/pVP1 robustly augmented T lymphocytes proliferation and CVB3-specific cytotoxic T lymphocyte responses. Importantly, 16 weeks after the last immunization, pAIM2/pVP1 co-immunization significantly enhanced the expression of Bcl-6, SOCS3, and Sca-1 which are critical for memory CD8 T cells as compared with pVP1 immunization. Notably, CD8 T cells that are likely vaccine-induced memory T cells were responsible for the protective efficacy of pAIM2/pVP1 vaccine by abolition of a CD8 T cell immune response following a lethal dose of CVB3 infection. Our results indicate that AIM2-adjuvanted vaccine could be a potential and promising approach to promote a long-lasting protection against CVB3-induced myocarditis." @default.
• W2621731562 created "2017-06-15" @default.
• W2621731562 creator A5007108734 @default.
• W2621731562 creator A5014091064 @default.
• W2621731562 creator A5031150824 @default.
• W2621731562 creator A5077563164 @default.
• W2621731562 creator A5091560656 @default.
• W2621731562 date "2017-06-08" @default.
• W2621731562 modified "2023-10-16" @default.
• W2621731562 title "AIM2 Co-immunization with VP1 Is Associated with Increased Memory CD8 T Cells and Mounts Long Lasting Protection against Coxsackievirus B3 Challenge" @default.
• W2621731562 cites W1498216094 @default.
• W2621731562 cites W1590207521 @default.
• W2621731562 cites W1911943885 @default.
• W2621731562 cites W1942194807 @default.
• W2621731562 cites W1966635341 @default.
• W2621731562 cites W1975300031 @default.
• W2621731562 cites W1991318832 @default.
• W2621731562 cites W1993026721 @default.
• W2621731562 cites W1997158699 @default.
• W2621731562 cites W1998206819 @default.
• W2621731562 cites W2006789517 @default.
• W2621731562 cites W2023809975 @default.
• W2621731562 cites W2028787589 @default.
• W2621731562 cites W2039421590 @default.
• W2621731562 cites W2041110737 @default.
• W2621731562 cites W2042288276 @default.
• W2621731562 cites W2042816890 @default.
• W2621731562 cites W2049439500 @default.
• W2621731562 cites W2054500142 @default.
• W2621731562 cites W2061141391 @default.
• W2621731562 cites W2063452309 @default.
• W2621731562 cites W2065620260 @default.
• W2621731562 cites W2068414412 @default.
• W2621731562 cites W2068914296 @default.
• W2621731562 cites W2075345074 @default.
• W2621731562 cites W2081232744 @default.
• W2621731562 cites W2081339485 @default.
• W2621731562 cites W2083236593 @default.
• W2621731562 cites W2098854209 @default.
• W2621731562 cites W2102196716 @default.
• W2621731562 cites W2104195963 @default.
• W2621731562 cites W2114931832 @default.
• W2621731562 cites W2126552441 @default.
• W2621731562 cites W2129168171 @default.
• W2621731562 cites W2133205326 @default.
• W2621731562 cites W2134916334 @default.
• W2621731562 cites W2140237734 @default.
• W2621731562 cites W2144150351 @default.
• W2621731562 cites W2145058760 @default.
• W2621731562 cites W2146890397 @default.
• W2621731562 cites W2150634944 @default.
• W2621731562 cites W2157305255 @default.
• W2621731562 cites W2157962982 @default.
• W2621731562 cites W2159153132 @default.
• W2621731562 cites W2165275387 @default.
• W2621731562 cites W2166889324 @default.
• W2621731562 cites W2180890615 @default.
• W2621731562 cites W2396609802 @default.
• W2621731562 cites W2473971766 @default.
• W2621731562 cites W2586644839 @default.
• W2621731562 cites W338093281 @default.
• W2621731562 cites W4232262676 @default.
• W2621731562 doi "https://doi.org/10.3389/fcimb.2017.00247" @default.
• W2621731562 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5462951" @default.
• W2621731562 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28642849" @default.
• W2621731562 hasPublicationYear "2017" @default.
• W2621731562 type Work @default.
• W2621731562 sameAs 2621731562 @default.
• W2621731562 citedByCount "10" @default.
• W2621731562 countsByYear W26217315622017 @default.
• W2621731562 countsByYear W26217315622020 @default.
• W2621731562 countsByYear W26217315622021 @default.
• W2621731562 countsByYear W26217315622022 @default.
• W2621731562 countsByYear W26217315622023 @default.
• W2621731562 crossrefType "journal-article" @default.
• W2621731562 hasAuthorship W2621731562A5007108734 @default.
• W2621731562 hasAuthorship W2621731562A5014091064 @default.
• W2621731562 hasAuthorship W2621731562A5031150824 @default.
• W2621731562 hasAuthorship W2621731562A5077563164 @default.
• W2621731562 hasAuthorship W2621731562A5091560656 @default.
• W2621731562 hasBestOaLocation W26217315621 @default.
• W2621731562 hasConcept C126322002 @default.
• W2621731562 hasConcept C154317977 @default.
• W2621731562 hasConcept C159047783 @default.
• W2621731562 hasConcept C167508917 @default.
• W2621731562 hasConcept C167672396 @default.
• W2621731562 hasConcept C202751555 @default.
• W2621731562 hasConcept C203014093 @default.
• W2621731562 hasConcept C2522874641 @default.
• W2621731562 hasConcept C2777863537 @default.
• W2621731562 hasConcept C2780801004 @default.
• W2621731562 hasConcept C2780875844 @default.
• W2621731562 hasConcept C2909190889 @default.
• W2621731562 hasConcept C55493867 @default.
• W2621731562 hasConcept C71924100 @default.
• W2621731562 hasConcept C86803240 @default.
• W2621731562 hasConcept C8891405 @default.
• W2621731562 hasConceptScore W2621731562C126322002 @default.
• W2621731562 hasConceptScore W2621731562C154317977 @default.
• W2621731562 hasConceptScore W2621731562C159047783 @default.

• next