Matches in SemOpenAlex for { <https://semopenalex.org/work/W2622143662> ?p ?o ?g. }
Showing items 1 to 96 of
96
with 100 items per page.
- W2622143662 endingPage "202" @default.
- W2622143662 startingPage "198" @default.
- W2622143662 abstract "Background: There is a need to measure antibiotic resistance of Pseudomonas aeruginosa (PA) in cystic fibrosis (CF), either qualitatively or quantitatively, to inform patient management. The aim of this study was to develop a simple method by which resistance can be quantified by calculating a relative resistance index (RRI), and to assess correlation of RRIs with clinical variables.Methods: In our model, RRIs were calculated based on resistance to aztreonam, ceftazidime, ciprofloxacin, colistin, meropenem, tazocin, temicillin and tobramycin. Eighty-five adults with CF and chronic PA colonisation were identified. For each, all PA cultures were allocated a score of 0 for susceptible, 0.5 for intermediate resistance or 1 for resistance for each antibiotic listed above, and the RRI calculated by dividing the sum of these by the number of antibiotics, giving a maximum score of 1. The mean RRIs for all cultures were correlated with key clinical variables monitored in CF patients (including age, FEV1, IV antibiotic days and BMI).Results: RRIs for non-mucoid PA exhibited moderate positive correlation with total number of IV days (r = 0.405; p < 0.001) and moderate negative correlation with FEV1 % predicted (r = −0.437; p < 0.001). RRIs were not significantly correlated with duration of colonisation, typing (clonal vs other strain) or BMI. Median RRIs were significantly higher for females (0.26, IQR 0.13–0.54) than males (0.18, IQR 0.07–0.37) for non-mucoid PA only (p = 0.03).Conclusions: RRI is an easily calculated measure that correlates with other clinical variables in CF patients and enables quantitative monitoring of resistance." @default.
- W2622143662 created "2017-06-15" @default.
- W2622143662 creator A5004707517 @default.
- W2622143662 creator A5033892561 @default.
- W2622143662 creator A5040721400 @default.
- W2622143662 creator A5048945685 @default.
- W2622143662 creator A5049298196 @default.
- W2622143662 creator A5060848881 @default.
- W2622143662 creator A5087398782 @default.
- W2622143662 date "2017-07-26" @default.
- W2622143662 modified "2023-10-14" @default.
- W2622143662 title "Relative resistance index (RRI) – a scoring system for antibiotic resistance in Pseudomonas aeruginosa" @default.
- W2622143662 cites W1992444327 @default.
- W2622143662 cites W2055261049 @default.
- W2622143662 cites W2088668762 @default.
- W2622143662 cites W2107154370 @default.
- W2622143662 cites W2115505766 @default.
- W2622143662 cites W2142443730 @default.
- W2622143662 cites W2155069031 @default.
- W2622143662 cites W2155721944 @default.
- W2622143662 cites W2346216498 @default.
- W2622143662 cites W2592042928 @default.
- W2622143662 doi "https://doi.org/10.1080/09674845.2017.1338500" @default.
- W2622143662 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28745144" @default.
- W2622143662 hasPublicationYear "2017" @default.
- W2622143662 type Work @default.
- W2622143662 sameAs 2622143662 @default.
- W2622143662 citedByCount "7" @default.
- W2622143662 countsByYear W26221436622017 @default.
- W2622143662 countsByYear W26221436622018 @default.
- W2622143662 countsByYear W26221436622019 @default.
- W2622143662 countsByYear W26221436622020 @default.
- W2622143662 crossrefType "journal-article" @default.
- W2622143662 hasAuthorship W2622143662A5004707517 @default.
- W2622143662 hasAuthorship W2622143662A5033892561 @default.
- W2622143662 hasAuthorship W2622143662A5040721400 @default.
- W2622143662 hasAuthorship W2622143662A5048945685 @default.
- W2622143662 hasAuthorship W2622143662A5049298196 @default.
- W2622143662 hasAuthorship W2622143662A5060848881 @default.
- W2622143662 hasAuthorship W2622143662A5087398782 @default.
- W2622143662 hasBestOaLocation W26221436622 @default.
- W2622143662 hasConcept C126322002 @default.
- W2622143662 hasConcept C2775832221 @default.
- W2622143662 hasConcept C2776938444 @default.
- W2622143662 hasConcept C2777637488 @default.
- W2622143662 hasConcept C2778512257 @default.
- W2622143662 hasConcept C2778974779 @default.
- W2622143662 hasConcept C2779631663 @default.
- W2622143662 hasConcept C2780416669 @default.
- W2622143662 hasConcept C501593827 @default.
- W2622143662 hasConcept C523546767 @default.
- W2622143662 hasConcept C54355233 @default.
- W2622143662 hasConcept C71924100 @default.
- W2622143662 hasConcept C86803240 @default.
- W2622143662 hasConcept C89423630 @default.
- W2622143662 hasConcept C90924648 @default.
- W2622143662 hasConcept C94665300 @default.
- W2622143662 hasConceptScore W2622143662C126322002 @default.
- W2622143662 hasConceptScore W2622143662C2775832221 @default.
- W2622143662 hasConceptScore W2622143662C2776938444 @default.
- W2622143662 hasConceptScore W2622143662C2777637488 @default.
- W2622143662 hasConceptScore W2622143662C2778512257 @default.
- W2622143662 hasConceptScore W2622143662C2778974779 @default.
- W2622143662 hasConceptScore W2622143662C2779631663 @default.
- W2622143662 hasConceptScore W2622143662C2780416669 @default.
- W2622143662 hasConceptScore W2622143662C501593827 @default.
- W2622143662 hasConceptScore W2622143662C523546767 @default.
- W2622143662 hasConceptScore W2622143662C54355233 @default.
- W2622143662 hasConceptScore W2622143662C71924100 @default.
- W2622143662 hasConceptScore W2622143662C86803240 @default.
- W2622143662 hasConceptScore W2622143662C89423630 @default.
- W2622143662 hasConceptScore W2622143662C90924648 @default.
- W2622143662 hasConceptScore W2622143662C94665300 @default.
- W2622143662 hasIssue "4" @default.
- W2622143662 hasLocation W26221436621 @default.
- W2622143662 hasLocation W26221436622 @default.
- W2622143662 hasLocation W26221436623 @default.
- W2622143662 hasOpenAccess W2622143662 @default.
- W2622143662 hasPrimaryLocation W26221436621 @default.
- W2622143662 hasRelatedWork W155492995 @default.
- W2622143662 hasRelatedWork W2002540126 @default.
- W2622143662 hasRelatedWork W2003946063 @default.
- W2622143662 hasRelatedWork W2062216886 @default.
- W2622143662 hasRelatedWork W2075072320 @default.
- W2622143662 hasRelatedWork W2158260706 @default.
- W2622143662 hasRelatedWork W2166164946 @default.
- W2622143662 hasRelatedWork W2948303782 @default.
- W2622143662 hasRelatedWork W2975560964 @default.
- W2622143662 hasRelatedWork W4307459913 @default.
- W2622143662 hasVolume "74" @default.
- W2622143662 isParatext "false" @default.
- W2622143662 isRetracted "false" @default.
- W2622143662 magId "2622143662" @default.
- W2622143662 workType "article" @default.