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- W2622387739 abstract "Heat shock proteins 90 (Hsp90) and 70 (Hsp70) are two families of highly conserved ATP-dependent molecular chaperones that fold and remodel proteins. Both are important components of the cellular machinery involved in protein homeostasis and participate in nearly every cellular process. Although Hsp90 and Hsp70 each carry out some chaperone activities independently, they collaborate in other cellular remodeling reactions. In eukaryotes, both Hsp90 and Hsp70 function with numerous Hsp90 and Hsp70 co-chaperones. In contrast, bacterial Hsp90 and Hsp70 are less complex; Hsp90 acts independently of co-chaperones, and Hsp70 uses two co-chaperones. In this review, we focus on recent progress toward understanding the basic mechanisms of Hsp90-mediated protein remodeling and the collaboration between Hsp90 and Hsp70, with an emphasis on bacterial chaperones. We describe the structure and conformational dynamics of these chaperones and their interactions with each other and with client proteins. The physiological roles of Hsp90 in Escherichia coli and other bacteria are also discussed. We anticipate that the information gained from exploring the mechanism of the bacterial chaperone system will provide the groundwork for understanding the more complex eukaryotic Hsp90 system and its modulation by Hsp90 co-chaperones." @default.
- W2622387739 created "2017-06-15" @default.
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- W2622387739 date "2017-07-01" @default.
- W2622387739 modified "2023-09-25" @default.
- W2622387739 title "Association Between The (GT)n Polymorphism Of The HSP-32 (HO-1), HSP-70 and HSP-90 And Acute Pancreatitis" @default.
- W2622387739 doi "https://doi.org/10.1016/j.pan.2017.05.258" @default.
- W2622387739 hasPublicationYear "2017" @default.
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