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- W2622401982 startingPage "33" @default.
- W2622401982 abstract "While members of the Kingdom Fungi are found across many of the world’s most hostile environments, only a limited number of species can thrive within the human host. The causative agents of the most common invasive fungal infections are Candida albicans, Aspergillus fumigatus, and Cryptococcus neoformans. During the infection process, these fungi must not only combat the host immune system while adapting to dramatic changes in temperature and pH, but also acquire sufficient nutrients to enable growth and dissemination in the host. One class of nutrients required by fungi, which is found in varying concentrations in their environmental niches and the human host, is the purines. These nitrogen-containing heterocycles are one of the most abundant organic molecules in nature and are required for roles as diverse as signal transduction, energy metabolism and DNA synthesis. The most common life-threatening fungal pathogens can degrade, salvage and synthesize de novo purines through a number of enzymatic steps that are conserved. While these enable them to adapt to the changing purine availability in the environment, only de novo purine biosynthesis is essential during infection and therefore an attractive antimycotic target." @default.
- W2622401982 created "2017-06-15" @default.
- W2622401982 creator A5065433879 @default.
- W2622401982 creator A5091752903 @default.
- W2622401982 date "2017-06-08" @default.
- W2622401982 modified "2023-10-16" @default.
- W2622401982 title "Purine Acquisition and Synthesis by Human Fungal Pathogens" @default.
- W2622401982 cites W1489790705 @default.
- W2622401982 cites W1521756421 @default.
- W2622401982 cites W1535874378 @default.
- W2622401982 cites W1539520796 @default.
- W2622401982 cites W155427695 @default.
- W2622401982 cites W1564660212 @default.
- W2622401982 cites W1589482077 @default.
- W2622401982 cites W1681833908 @default.
- W2622401982 cites W1784319065 @default.
- W2622401982 cites W1824218087 @default.
- W2622401982 cites W1938843555 @default.
- W2622401982 cites W1965804472 @default.
- W2622401982 cites W1969511656 @default.
- W2622401982 cites W1971705479 @default.
- W2622401982 cites W1973847153 @default.
- W2622401982 cites W1980003414 @default.
- W2622401982 cites W1980410713 @default.
- W2622401982 cites W1980901364 @default.
- W2622401982 cites W1982151856 @default.
- W2622401982 cites W1983377204 @default.
- W2622401982 cites W1987985725 @default.
- W2622401982 cites W1989148845 @default.
- W2622401982 cites W1996783999 @default.
- W2622401982 cites W1998069931 @default.
- W2622401982 cites W1998602558 @default.
- W2622401982 cites W2000102090 @default.
- W2622401982 cites W2006715432 @default.
- W2622401982 cites W2011245487 @default.
- W2622401982 cites W2012702774 @default.
- W2622401982 cites W2017889698 @default.
- W2622401982 cites W2019920171 @default.
- W2622401982 cites W2020503272 @default.
- W2622401982 cites W2021407910 @default.
- W2622401982 cites W2022294513 @default.
- W2622401982 cites W2022967146 @default.
- W2622401982 cites W2023661478 @default.
- W2622401982 cites W2029662459 @default.
- W2622401982 cites W2030271109 @default.
- W2622401982 cites W2035806918 @default.
- W2622401982 cites W2035960777 @default.
- W2622401982 cites W2045074917 @default.
- W2622401982 cites W2045138757 @default.
- W2622401982 cites W2046337822 @default.
- W2622401982 cites W2051350436 @default.
- W2622401982 cites W2063873410 @default.
- W2622401982 cites W2066253824 @default.
- W2622401982 cites W2067035154 @default.
- W2622401982 cites W2067503599 @default.
- W2622401982 cites W2068743761 @default.
- W2622401982 cites W2076412057 @default.
- W2622401982 cites W2078123631 @default.
- W2622401982 cites W2078190145 @default.
- W2622401982 cites W2082304674 @default.
- W2622401982 cites W2084694036 @default.
- W2622401982 cites W2085415570 @default.
- W2622401982 cites W2092806983 @default.
- W2622401982 cites W2094066375 @default.
- W2622401982 cites W2095331773 @default.
- W2622401982 cites W2098472248 @default.
- W2622401982 cites W2100822273 @default.
- W2622401982 cites W2102763929 @default.
- W2622401982 cites W2104043278 @default.
- W2622401982 cites W2104753262 @default.
- W2622401982 cites W2105946152 @default.
- W2622401982 cites W2108886858 @default.
- W2622401982 cites W2111571652 @default.
- W2622401982 cites W2116646133 @default.
- W2622401982 cites W2118442490 @default.
- W2622401982 cites W2122002065 @default.
- W2622401982 cites W2122427889 @default.
- W2622401982 cites W2125728208 @default.
- W2622401982 cites W2127363691 @default.
- W2622401982 cites W2141197648 @default.
- W2622401982 cites W2142686276 @default.
- W2622401982 cites W2143691385 @default.
- W2622401982 cites W2144543496 @default.
- W2622401982 cites W2145106986 @default.
- W2622401982 cites W2148371056 @default.
- W2622401982 cites W2148847926 @default.
- W2622401982 cites W2149002422 @default.
- W2622401982 cites W2149286475 @default.
- W2622401982 cites W2151458427 @default.
- W2622401982 cites W2151869311 @default.
- W2622401982 cites W2153911335 @default.
- W2622401982 cites W2155360686 @default.
- W2622401982 cites W2155800098 @default.
- W2622401982 cites W2160143310 @default.
- W2622401982 cites W2160198598 @default.
- W2622401982 cites W2160445461 @default.
- W2622401982 cites W2167655118 @default.
- W2622401982 cites W2167867974 @default.