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• W2622430247 endingPage "1868" @default.
• W2622430247 startingPage "1861" @default.
• W2622430247 abstract "Polyamidoamine (PAMAM) dendrimers have been investigated as a potential platform for a number of ocular drugs, but only in aqueous solution. In this work we have developed fast dissolving dendrimer-based nanofibers (DNF) as a topical delivery vehicle for the glaucoma drug brimonidine tartrate (BT). The safety and drug release kinetics of these nanofiber mats were evaluated in vitro and in vivo. DNF caused no toxicity at therapeutic levels in cultured cells or ocular irritation in animal tests using a normotensive rat model. Intra-ocular pressure response was equivalent between DNF and BT solution in a single dose test, but DNF showed improved efficacy with daily dosing over a 3-week test period. This study indicates electrospun dendrimer nanofibers are a viable alternative to aqueous solutions as a more efficient method of administering antiglaucoma drug topically." @default.
• W2622430247 created "2017-06-15" @default.
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• W2622430247 date "2017-06-22" @default.
• W2622430247 modified "2023-09-29" @default.
• W2622430247 title "Fast Dissolving Dendrimer Nanofiber Mats as Alternative to Eye Drops for More Efficient Antiglaucoma Drug Delivery" @default.
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• W2622430247 doi "https://doi.org/10.1021/acsbiomaterials.7b00319" @default.
• W2622430247 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5685521" @default.
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