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• W2622433887 abstract "Selenium is well documented to inhibit cancer at higher doses; however, the mechanism behind this inhibition varies widely depending on the cell type and selenium species. Previously, we have demonstrated that Bacillus licheniformis JS2 derived biogenic selenium nanoparticles (SeNPs) induce non-apoptotic cell death in prostate adenocarcinoma cell line, PC-3, at a minimal concentration of 2 µg Se/ml, without causing toxicity to the primary cells. However, the mechanism behind its anticancer activity was elusive.Our results have shown that these SeNPs at a concentration of 2 µg Se/ml were able to induce reactive oxygen species (ROS) mediated necroptosis in PC-3 cells by gaining cellular internalization. Real-time qPCR analysis showed increased expression of necroptosis associated tumor necrotic factor (TNF) and interferon regulatory factor 1 (IRF1). An increased expression of RIP1 protein was also observed at the translational level upon SeNP treatment. Moreover, the cell viability was significantly increased in the presence of necroptosis inhibitor, Necrostatin-1.Data suggest that our biogenic SeNPs induce cell death in PC-3 cells by the ROS-mediated activation of necroptosis, independent to RIP3 and MLKL, regulated by a RIP1 kinase." @default.
• W2622433887 created "2017-06-15" @default.
• W2622433887 creator A5025449800 @default.
• W2622433887 creator A5084105109 @default.
• W2622433887 date "2017-06-07" @default.
• W2622433887 modified "2023-10-17" @default.
• W2622433887 title "Biogenic selenium nanoparticles induce ROS-mediated necroptosis in PC-3 cancer cells through TNF activation" @default.
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• W2622433887 doi "https://doi.org/10.1186/s12951-017-0276-3" @default.
• W2622433887 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5463494" @default.
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• W2622433887 hasPublicationYear "2017" @default.
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