FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2622472130> ?p ?o ?g. }

• W2622472130 endingPage "e0178995" @default.
• W2622472130 startingPage "e0178995" @default.
• W2622472130 abstract "Head and neck paragangliomas (HNPGLs) are rare tumors that may cause important morbidity, because of their tendency to infiltrate the skull base. At present, surgery is the only therapeutic option, but radical removal may be difficult or impossible. Thus, effective targets and molecules for HNPGL treatment need to be identified. However, the lack of cellular models for this rare tumor hampers this task. PPARα receptor activation was reported in several tumors and this receptor appears to be a promising therapeutic target in different malignancies. Considering that the role of PPARα in HNPGLs was never studied before, we analyzed the potential of modulating PPARα in a unique model of HNPGL cells. We observed an intense immunoreactivity for PPARα in HNPGL tumors, suggesting that this receptor has an important role in HNPGL. A pronounced nuclear expression of PPARα was also confirmed in HNPGL-derived cells. The specific PPARα agonist WY14643 had no effect on HNPGL cell viability, whereas the specific PPARα antagonist GW6471 reduced HNPGL cell viability and growth by inducing cell cycle arrest and caspase-dependent apoptosis. GW6471 treatment was associated with a marked decrease of CDK4, cyclin D3 and cyclin B1 protein expression, along with an increased expression of p21 in HNPGL cells. Moreover, GW6471 drastically impaired clonogenic activity of HNPGL cells, with a less marked effect on cell migration. Notably, the effects of GW6471 on HNPGL cells were associated with the inhibition of the PI3K/GSK3β/β-catenin signaling pathway. In conclusion, the PPARα antagonist GW6471 reduces HNPGL cell viability, interfering with cell cycle and inducing apoptosis. The mechanisms affecting HNPGL cell viability involve repression of the PI3K/GSK3β/β-catenin pathway. Therefore, PPARα could represent a novel therapeutic target for HNPGL." @default.
• W2622472130 created "2017-06-15" @default.
• W2622472130 creator A5011391930 @default.
• W2622472130 creator A5022113326 @default.
• W2622472130 creator A5027204492 @default.
• W2622472130 creator A5032401096 @default.
• W2622472130 creator A5036040057 @default.
• W2622472130 creator A5036755666 @default.
• W2622472130 creator A5045894601 @default.
• W2622472130 creator A5052183778 @default.
• W2622472130 creator A5055320904 @default.
• W2622472130 creator A5055796767 @default.
• W2622472130 creator A5056405634 @default.
• W2622472130 creator A5060018150 @default.
• W2622472130 creator A5082066434 @default.
• W2622472130 creator A5083037380 @default.
• W2622472130 creator A5091627342 @default.
• W2622472130 date "2017-06-08" @default.
• W2622472130 modified "2023-09-23" @default.
• W2622472130 title "Effects of PPARα inhibition in head and neck paraganglioma cells" @default.
• W2622472130 cites W1820939478 @default.
• W2622472130 cites W1908444498 @default.
• W2622472130 cites W1980930152 @default.
• W2622472130 cites W1982046186 @default.
• W2622472130 cites W1989848456 @default.
• W2622472130 cites W1997755216 @default.
• W2622472130 cites W2004507031 @default.
• W2622472130 cites W2008388141 @default.
• W2622472130 cites W2018171566 @default.
• W2622472130 cites W2021226225 @default.
• W2622472130 cites W2025719835 @default.
• W2622472130 cites W2025762055 @default.
• W2622472130 cites W2034131665 @default.
• W2622472130 cites W2041352419 @default.
• W2622472130 cites W2043213668 @default.
• W2622472130 cites W2046802352 @default.
• W2622472130 cites W2083242271 @default.
• W2622472130 cites W2086144879 @default.
• W2622472130 cites W2088386132 @default.
• W2622472130 cites W2089320077 @default.
• W2622472130 cites W2096439168 @default.
• W2622472130 cites W2110378444 @default.
• W2622472130 cites W2114657901 @default.
• W2622472130 cites W2126511952 @default.
• W2622472130 cites W2132834292 @default.
• W2622472130 cites W2157101941 @default.
• W2622472130 cites W2157639204 @default.
• W2622472130 cites W2168300082 @default.
• W2622472130 cites W2284133339 @default.
• W2622472130 cites W2520632143 @default.
• W2622472130 cites W2530502777 @default.
• W2622472130 cites W2913517897 @default.
• W2622472130 cites W4230982340 @default.
• W2622472130 doi "https://doi.org/10.1371/journal.pone.0178995" @default.
• W2622472130 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5464765" @default.
• W2622472130 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28594934" @default.
• W2622472130 hasPublicationYear "2017" @default.
• W2622472130 type Work @default.
• W2622472130 sameAs 2622472130 @default.
• W2622472130 citedByCount "29" @default.
• W2622472130 countsByYear W26224721302018 @default.
• W2622472130 countsByYear W26224721302019 @default.
• W2622472130 countsByYear W26224721302020 @default.
• W2622472130 countsByYear W26224721302021 @default.
• W2622472130 countsByYear W26224721302022 @default.
• W2622472130 countsByYear W26224721302023 @default.
• W2622472130 crossrefType "journal-article" @default.
• W2622472130 hasAuthorship W2622472130A5011391930 @default.
• W2622472130 hasAuthorship W2622472130A5022113326 @default.
• W2622472130 hasAuthorship W2622472130A5027204492 @default.
• W2622472130 hasAuthorship W2622472130A5032401096 @default.
• W2622472130 hasAuthorship W2622472130A5036040057 @default.
• W2622472130 hasAuthorship W2622472130A5036755666 @default.
• W2622472130 hasAuthorship W2622472130A5045894601 @default.
• W2622472130 hasAuthorship W2622472130A5052183778 @default.
• W2622472130 hasAuthorship W2622472130A5055320904 @default.
• W2622472130 hasAuthorship W2622472130A5055796767 @default.
• W2622472130 hasAuthorship W2622472130A5056405634 @default.
• W2622472130 hasAuthorship W2622472130A5060018150 @default.
• W2622472130 hasAuthorship W2622472130A5082066434 @default.
• W2622472130 hasAuthorship W2622472130A5083037380 @default.
• W2622472130 hasAuthorship W2622472130A5091627342 @default.
• W2622472130 hasBestOaLocation W26224721301 @default.
• W2622472130 hasConcept C117262875 @default.
• W2622472130 hasConcept C170493617 @default.
• W2622472130 hasConcept C187345961 @default.
• W2622472130 hasConcept C190283241 @default.
• W2622472130 hasConcept C29537977 @default.
• W2622472130 hasConcept C502942594 @default.
• W2622472130 hasConcept C53227056 @default.
• W2622472130 hasConcept C55493867 @default.
• W2622472130 hasConcept C62112901 @default.
• W2622472130 hasConcept C86803240 @default.
• W2622472130 hasConcept C95444343 @default.
• W2622472130 hasConceptScore W2622472130C117262875 @default.
• W2622472130 hasConceptScore W2622472130C170493617 @default.
• W2622472130 hasConceptScore W2622472130C187345961 @default.
• W2622472130 hasConceptScore W2622472130C190283241 @default.

• next