FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2622562723> ?p ?o ?g. }

• W2622562723 endingPage "1777" @default.
• W2622562723 startingPage "1767" @default.
• W2622562723 abstract "Antibacterial resistance has become a serious crisis for world health over the last few decades, so that new therapeutic approaches are strongly needed to face the threat of resistant infections. Transcription factor decoys (TFD) are a promising new class of antimicrobial oligonucleotides with proven in vivo activity when combined with a bolaamphiphilic cationic molecule, 12-bis-THA. These two molecular species form stable nanoplexes which, however, present very scarce colloidal stability in physiological media, which poses the challenge of drug formulation and delivery. In this work, we reformulated the 12-bis-THA/TFD nanoplexes in a liposomal carrier, which retains the ability to protect the oligonucleotide therapeutic from degradation and deliver it across the bacterial cell wall. We performed a physical-chemical study to investigate how the incorporation of 12-bis-THA and TFD affects the structure of POPC- and POPC/DOPE liposomes. Analysis was performed using dynamic light scattering (DLS), ζ-potential measurements, small-angle x-ray scattering (SAXS), and steady-state fluorescence spectroscopy to better understand the structure of the liposomal formulations containing the 12-bis-THA/TFD complexes. Oligonucleotide delivery to model Escherichia coli bacteria was assessed by means of confocal scanning laser microscopy (CLSM), evidencing the requirement of a fusogenic helper lipid for transfection. Preliminary biological assessments suggested the necessity of further development by modulation of 12-bis-THA concentration in order to optimize its therapeutic index, i.e. the ratio of antibacterial activity to the observed cytotoxicity. In summary, POPC/DOPE/12-bis-THA liposomes appear as promising formulations for TFD delivery." @default.
• W2622562723 created "2017-06-15" @default.
• W2622562723 creator A5013080220 @default.
• W2622562723 creator A5017193470 @default.
• W2622562723 creator A5029711509 @default.
• W2622562723 creator A5040213906 @default.
• W2622562723 creator A5046264714 @default.
• W2622562723 creator A5053312586 @default.
• W2622562723 creator A5070328782 @default.
• W2622562723 creator A5079003288 @default.
• W2622562723 creator A5088187218 @default.
• W2622562723 creator A5088883064 @default.
• W2622562723 creator A5091851463 @default.
• W2622562723 date "2017-10-01" @default.
• W2622562723 modified "2023-09-29" @default.
• W2622562723 title "Cationic liposomal vectors incorporating a bolaamphiphile for oligonucleotide antimicrobials" @default.
• W2622562723 cites W1549152014 @default.
• W2622562723 cites W169814353 @default.
• W2622562723 cites W1963552167 @default.
• W2622562723 cites W1969060550 @default.
• W2622562723 cites W1978195377 @default.
• W2622562723 cites W1981522326 @default.
• W2622562723 cites W1987885263 @default.
• W2622562723 cites W1989712861 @default.
• W2622562723 cites W1996424750 @default.
• W2622562723 cites W2009113911 @default.
• W2622562723 cites W2010912813 @default.
• W2622562723 cites W2015178572 @default.
• W2622562723 cites W2025294279 @default.
• W2622562723 cites W2029494296 @default.
• W2622562723 cites W2034342858 @default.
• W2622562723 cites W2039096198 @default.
• W2622562723 cites W2052544119 @default.
• W2622562723 cites W2054185238 @default.
• W2622562723 cites W2058707261 @default.
• W2622562723 cites W2062580204 @default.
• W2622562723 cites W2069329657 @default.
• W2622562723 cites W2076163624 @default.
• W2622562723 cites W2076491038 @default.
• W2622562723 cites W2079462709 @default.
• W2622562723 cites W2090433719 @default.
• W2622562723 cites W2092770422 @default.
• W2622562723 cites W2116837113 @default.
• W2622562723 cites W2118781326 @default.
• W2622562723 cites W2122676372 @default.
• W2622562723 cites W2132911648 @default.
• W2622562723 cites W2137323781 @default.
• W2622562723 cites W2160679445 @default.
• W2622562723 cites W2170543410 @default.
• W2622562723 cites W2229987747 @default.
• W2622562723 cites W2239738725 @default.
• W2622562723 cites W2297224545 @default.
• W2622562723 cites W2300671107 @default.
• W2622562723 cites W2313837094 @default.
• W2622562723 cites W2315329709 @default.
• W2622562723 cites W2346680648 @default.
• W2622562723 cites W2402171825 @default.
• W2622562723 cites W2562944419 @default.
• W2622562723 cites W2580748322 @default.
• W2622562723 cites W2600536947 @default.
• W2622562723 doi "https://doi.org/10.1016/j.bbamem.2017.06.006" @default.
• W2622562723 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28610721" @default.
• W2622562723 hasPublicationYear "2017" @default.
• W2622562723 type Work @default.
• W2622562723 sameAs 2622562723 @default.
• W2622562723 citedByCount "20" @default.
• W2622562723 countsByYear W26225627232017 @default.
• W2622562723 countsByYear W26225627232018 @default.
• W2622562723 countsByYear W26225627232019 @default.
• W2622562723 countsByYear W26225627232020 @default.
• W2622562723 countsByYear W26225627232021 @default.
• W2622562723 countsByYear W26225627232022 @default.
• W2622562723 crossrefType "journal-article" @default.
• W2622562723 hasAuthorship W2622562723A5013080220 @default.
• W2622562723 hasAuthorship W2622562723A5017193470 @default.
• W2622562723 hasAuthorship W2622562723A5029711509 @default.
• W2622562723 hasAuthorship W2622562723A5040213906 @default.
• W2622562723 hasAuthorship W2622562723A5046264714 @default.
• W2622562723 hasAuthorship W2622562723A5053312586 @default.
• W2622562723 hasAuthorship W2622562723A5070328782 @default.
• W2622562723 hasAuthorship W2622562723A5079003288 @default.
• W2622562723 hasAuthorship W2622562723A5088187218 @default.
• W2622562723 hasAuthorship W2622562723A5088883064 @default.
• W2622562723 hasAuthorship W2622562723A5091851463 @default.
• W2622562723 hasBestOaLocation W26225627232 @default.
• W2622562723 hasConcept C104317684 @default.
• W2622562723 hasConcept C120665830 @default.
• W2622562723 hasConcept C121332964 @default.
• W2622562723 hasConcept C12554922 @default.
• W2622562723 hasConcept C129312508 @default.
• W2622562723 hasConcept C131888329 @default.
• W2622562723 hasConcept C14631669 @default.
• W2622562723 hasConcept C155672457 @default.
• W2622562723 hasConcept C155887181 @default.
• W2622562723 hasConcept C171250308 @default.
• W2622562723 hasConcept C185154212 @default.
• W2622562723 hasConcept C185592680 @default.
• W2622562723 hasConcept C191486275 @default.

• next