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- W2622765292 abstract "Sharp frequency selectivity, which is a hallmark of mammalian hearing, originates in the cochlea. However, the underlying mechanisms remain unclear. The pioneering work of von Bekesy showed that sounds launch waves of motion along the spiraling basilar membrane, and subsequent hydrodynamic analysis has shown how mechanical properties of the cochlear partition can interact with fluid forces to support sharp frequency tuning. These analyses have generally presumed (or even purported to prove) that longitudinal mechanical coupling through cochlear structures is negligible. Here, we demonstrate that the visco-elastic structure of the tectorial membrane (TM), a gelatinous structure that overlies the sensory receptor cells and plays a key role in stimulating them, also supports traveling waves. The distance over which TM waves propagate provides a measure of mechanical coupling and, through the cochlear map, determines a range of frequencies that correlates strikingly well with direct measurements of cochlear tuning in normal hearing mice, in mice with genetic disorders of hearing, and in humans. These results demonstrate significant longitudinal coupling through the TM and suggest that TM coupling plays an important role in determining the sharpness of cochlear frequency tuning." @default.
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- W2622765292 date "2017-05-01" @default.
- W2622765292 modified "2023-10-17" @default.
- W2622765292 title "Cochlear mechanisms underlying the sharp frequency selectivity of hearing" @default.
- W2622765292 doi "https://doi.org/10.1121/1.4987351" @default.
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