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- W2622919265 abstract "Genetic variations in the vacuolar protein sorting 10 protein (Vps10p) family have been linked to Alzheimer's disease (AD). Here we demonstrate deposition of fragments from the Vps10p member sortilin at senile plaques (SPs) in aged and AD human cerebrum. Sortilin changes were characterized in postmortem brains with antibodies against the extracellular and intracellular C-terminal domains. The two antibodies exhibited identical labeling in normal human cerebrum, occurring in the somata and dendrites of cortical and hippocampal neurons. The C-terminal antibody also marked extracellular lesions in some aged and all AD cases, appearing as isolated fibrils, mini-plaques, dense-packing or circular mature-looking plaques. Sortilin and β-amyloid (Aβ) deposition were correlated overtly in a region/lamina- and case-dependent manner as analyzed in the temporal lobe structures, with co-localized immunofluorescence seen at individual SPs. However, sortilin deposition rarely occurred around the pia, at vascular wall or in areas with typical diffuse Aβ deposition, with the labeling not enhanced by section pretreatment with heating or formic acid. Levels of a major sortilin fragment ~15 kDa, predicted to derive from the C-terminal region, were dramatically elevated in AD relative to control cortical lysates. Thus, sortilin fragments are a prominent constituent of the extracellularly deposited protein products at SPs in human cerebrum." @default.
- W2622919265 created "2017-06-15" @default.
- W2622919265 creator A5012834626 @default.
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- W2622919265 date "2017-06-07" @default.
- W2622919265 modified "2023-10-17" @default.
- W2622919265 title "Sortilin Fragments Deposit at Senile Plaques in Human Cerebrum" @default.
- W2622919265 cites W1228775382 @default.
- W2622919265 cites W1260792146 @default.
- W2622919265 cites W1523483038 @default.
- W2622919265 cites W1574188788 @default.
- W2622919265 cites W168886292 @default.
- W2622919265 cites W1849525423 @default.
- W2622919265 cites W1865472904 @default.
- W2622919265 cites W1963680576 @default.
- W2622919265 cites W1967464880 @default.
- W2622919265 cites W1969414063 @default.
- W2622919265 cites W1969479602 @default.
- W2622919265 cites W1972781517 @default.
- W2622919265 cites W1975432307 @default.
- W2622919265 cites W1982732238 @default.
- W2622919265 cites W1984544042 @default.
- W2622919265 cites W1986046759 @default.
- W2622919265 cites W1986312847 @default.
- W2622919265 cites W1987687780 @default.
- W2622919265 cites W1989018633 @default.
- W2622919265 cites W1994457811 @default.
- W2622919265 cites W1997957892 @default.
- W2622919265 cites W2001210466 @default.
- W2622919265 cites W2004960515 @default.
- W2622919265 cites W2005628140 @default.
- W2622919265 cites W2006617415 @default.
- W2622919265 cites W2008280197 @default.
- W2622919265 cites W2011724363 @default.
- W2622919265 cites W2018024956 @default.
- W2622919265 cites W2026940148 @default.
- W2622919265 cites W2027927801 @default.
- W2622919265 cites W2028727274 @default.
- W2622919265 cites W2030100345 @default.
- W2622919265 cites W2032920422 @default.
- W2622919265 cites W2033069175 @default.
- W2622919265 cites W2034151090 @default.
- W2622919265 cites W2038205848 @default.
- W2622919265 cites W2039220230 @default.
- W2622919265 cites W2042600422 @default.
- W2622919265 cites W2046344792 @default.
- W2622919265 cites W2046391671 @default.
- W2622919265 cites W2046847750 @default.
- W2622919265 cites W2053682876 @default.
- W2622919265 cites W2057212517 @default.
- W2622919265 cites W2058880763 @default.
- W2622919265 cites W2062020025 @default.
- W2622919265 cites W2062214806 @default.
- W2622919265 cites W2062489372 @default.
- W2622919265 cites W2064751532 @default.
- W2622919265 cites W2071039886 @default.
- W2622919265 cites W2071986823 @default.
- W2622919265 cites W2073164785 @default.
- W2622919265 cites W2073266663 @default.
- W2622919265 cites W2077706021 @default.
- W2622919265 cites W2081768441 @default.
- W2622919265 cites W2083153805 @default.
- W2622919265 cites W2089613882 @default.
- W2622919265 cites W2091861303 @default.
- W2622919265 cites W2092781004 @default.
- W2622919265 cites W2093104385 @default.
- W2622919265 cites W2093123126 @default.
- W2622919265 cites W2093153970 @default.
- W2622919265 cites W2093650784 @default.
- W2622919265 cites W2094007252 @default.
- W2622919265 cites W2095011840 @default.
- W2622919265 cites W2098665843 @default.
- W2622919265 cites W2100377941 @default.
- W2622919265 cites W2108676263 @default.
- W2622919265 cites W2110180331 @default.
- W2622919265 cites W2116262162 @default.
- W2622919265 cites W2122860201 @default.
- W2622919265 cites W2128228199 @default.
- W2622919265 cites W2129422864 @default.
- W2622919265 cites W2131478918 @default.
- W2622919265 cites W2134010906 @default.
- W2622919265 cites W2136714025 @default.
- W2622919265 cites W2139145543 @default.
- W2622919265 cites W2160181681 @default.
- W2622919265 cites W2170644095 @default.
- W2622919265 cites W2214346462 @default.
- W2622919265 cites W2231280169 @default.