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• W2623034330 endingPage "e96" @default.
• W2623034330 startingPage "e96" @default.
• W2623034330 abstract "OBJECTIVES: Acetaldehyde, the first metabolite of ethanol, is a definite carcinogen for the esophagus, head, and neck; and aldehyde dehydrogenase 2 (ALDH2) is a mitochondrial enzyme that catalyzes the metabolism of acetaldehyde. TheALDH2genotype exists asALDH2*1/*1(active ALDH2),ALDH2*1/*2(heterozygous inactive ALDH2), andALDH2*2/*2(homozygous inactive ALDH2). Many epidemiological studies have reported thatALDH2*2carriers are at high risk for esophageal or head and neck squamous cell carcinomas by habitual drinking. Therefore, identification ofALDH2*2carriers would be helpful for the prevention of those cancers, but there have been no methods suitable for mass screening to identify these individuals. METHODS: One hundred and eleven healthy volunteers (ALDH2*1/*1carriers: 53;ALDH2*1/*2carriers: 48; andALDH2*2/*2carriers: 10) were recruited. Breath samples were collected after drinking 100 ml of 0.5% ethanol using specially designed gas bags, and breath ethanol and acetaldehyde levels were measured by semiconductor gas chromatography. RESULTS: The median (range) breath acetaldehyde levels at 1 min after alcohol ingestion were 96.1 (18.1–399.0) parts per billion (p.p.b.) for theALDH2*1/*1genotype, 333.5 (78.4–1218.4) p.p.b. for theALDH2*1/*2genotype, and 537.1 (213.2–1353.8) p.p.b. for theALDH2*2/*2genotype. The breath acetaldehyde levels inALDH2*2carriers were significantly higher than for theALDH2*1/*1genotype. Notably, the ratio of breath acetaldehyde level-to-breath ethanol level could identify carriers of theALDH2*2allele very accurately (whole accuracy; 96.4%). CONCLUSIONS: Our novel breath test is a useful tool for identifyingALDH2*2carriers, who are at high risk for esophageal and head and neck cancers." @default.
• W2623034330 created "2017-06-15" @default.
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• W2623034330 date "2017-06-01" @default.
• W2623034330 modified "2023-09-23" @default.
• W2623034330 title "Establishment of a Quick and Highly Accurate Breath Test for ALDH2 Genotyping" @default.
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• W2623034330 doi "https://doi.org/10.1038/ctg.2017.24" @default.
• W2623034330 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5518947" @default.
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