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• W2623115360 abstract "Aim: To evaluate the clinical effectiveness of double cytotoxic drugs enhanced chemo immunotherapy in the treatment of advanced pancreatic cancer compared to single cytotoxic drugs by ultra-minimum incision personalized intra-tumoral chemo immunotherapy (UMIPIC-Therapy).Method: In study of UMIPIC with double drugs, 41 patients of pancreatic cancer were randomly divided into UMIPIC and ITCT groups, UMIPIC-D (n=30) treated with a proprietary therapeutic regimens including two cytotoxic drugs (Cytosine Arabinoside: Ara-C and Bleomycin: BLM) plus an oxidant and hapten, and ITCT-D (n=11) treated with same regimens intra-tumoral without the hapten. In UMIPIC with single drug, 45 patients of pancreatic cancer were randomly divided into two groups. UMIPIC-S (n=25) treated with a proprietary therapeutic regimens, it is composed of three intra-tumoral injections of a compound with an oxidant, a cytotoxic drug (Ara-C) and hapten. ITCT-S (n=20) uses an oxidant and a cytotoxic drug (Ara-C) without hapten. Both UMIPIC and ITCT use the same clinical therapeutic procedure.Results: For single drug, median survival was 6.45 months for UMIPIC-S vs 4.98 months for ITCT-S, (P<0.05), one year survival rate was 28% for UMIPIC-S vs 5% for ITCT-S (P<0.05). For double drugs, median survival was 15.5 months for UMIPIC-D vs 3 months in ITCT-D (P<0.01). The 6-month survival rate was 76.67% for UMIPIC-D vs 18.18% for ITCT-D (P<0.01) and 1-year survival rate for 56.67% UMIPIC-D vs 9.09% ITCT (P<0.01).Conclusion: UMIPIC for pancreatic cancer is a non-invasive and potentially effective therapy, and double cytotoxic drugs applied in the UMPIC-D revealed a significant advantage in prolonging the survival time." @default.
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• W2623115360 date "2015-12-30" @default.
• W2623115360 modified "2023-09-22" @default.
• W2623115360 title "Use of Hapten Combined Cytotoxic Drugs for Enhancing Therapeutic Effect in Advanced Stages of Pancreatic Cancer" @default.
• W2623115360 doi "https://doi.org/10.15406/jlrdt.2015.01.00013" @default.
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