FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2623227935> ?p ?o ?g. }

• W2623227935 abstract "Abstract The response regulator PhoP is part of the PhoP/PhoQ two‐component system, which is responsible for regulating the expression of multiple genes involved in controlling virulence, biofilm formation, and resistance to antimicrobial peptides. Therefore, modulating the transcriptional function of the PhoP protein is a promising strategy for developing new antimicrobial agents. There is evidence suggesting that phosphorylation‐mediated dimerization in the regulatory domain of PhoP is essential for its transcriptional function. Disruption or stabilization of protein‐protein interactions at the dimerization interface may inhibit or enhance the expression of PhoP‐dependent genes. In this study, we performed molecular dynamics simulations on the active and inactive dimers and monomers of the PhoP regulatory domains, followed by pocket‐detecting screenings and a quantitative hot‐spot analysis in order to assess the druggability of the protein. Consistent with prior hypothesis, the calculation of the binding free energy shows that phosphorylation enhances dimerization of PhoP. Furthermore, we have identified two different putative binding sites at the dimerization active site (the α4‐β5‐α5 face) with energetic “hot‐spot” areas, which could be used to search for modulators of protein‐protein interactions. This study delivers insight into the dynamics and druggability of the dimerization interface of the PhoP regulatory domain, and may serve as a basis for the rational identification of new antimicrobial drugs." @default.
• W2623227935 created "2017-06-15" @default.
• W2623227935 creator A5011858509 @default.
• W2623227935 creator A5017223512 @default.
• W2623227935 creator A5035266471 @default.
• W2623227935 creator A5052368521 @default.
• W2623227935 creator A5076288634 @default.
• W2623227935 date "2017-06-09" @default.
• W2623227935 modified "2023-10-16" @default.
• W2623227935 title "Computational Studies of the Active and Inactive Regulatory Domains of Response Regulator PhoP Using Molecular Dynamics Simulations" @default.
• W2623227935 cites W102875785 @default.
• W2623227935 cites W1517566065 @default.
• W2623227935 cites W1614390781 @default.
• W2623227935 cites W188879721 @default.
• W2623227935 cites W1949323217 @default.
• W2623227935 cites W1958031489 @default.
• W2623227935 cites W1963867445 @default.
• W2623227935 cites W1966084755 @default.
• W2623227935 cites W1973843350 @default.
• W2623227935 cites W1978693516 @default.
• W2623227935 cites W1979355916 @default.
• W2623227935 cites W1979414133 @default.
• W2623227935 cites W1998063251 @default.
• W2623227935 cites W1999189021 @default.
• W2623227935 cites W2000114467 @default.
• W2623227935 cites W2007152485 @default.
• W2623227935 cites W2013376035 @default.
• W2623227935 cites W2020459826 @default.
• W2623227935 cites W2033364819 @default.
• W2623227935 cites W2040159113 @default.
• W2623227935 cites W2044456503 @default.
• W2623227935 cites W2051710717 @default.
• W2623227935 cites W2052588312 @default.
• W2623227935 cites W2057477511 @default.
• W2623227935 cites W2057931054 @default.
• W2623227935 cites W2066672837 @default.
• W2623227935 cites W2071510805 @default.
• W2623227935 cites W2081693079 @default.
• W2623227935 cites W2083726121 @default.
• W2623227935 cites W2087574732 @default.
• W2623227935 cites W2091213797 @default.
• W2623227935 cites W2092808125 @default.
• W2623227935 cites W2101288419 @default.
• W2623227935 cites W2101996554 @default.
• W2623227935 cites W2102505558 @default.
• W2623227935 cites W2103977803 @default.
• W2623227935 cites W2108559568 @default.
• W2623227935 cites W2111345154 @default.
• W2623227935 cites W2114798043 @default.
• W2623227935 cites W2115156437 @default.
• W2623227935 cites W2115285855 @default.
• W2623227935 cites W2117639785 @default.
• W2623227935 cites W2118233996 @default.
• W2623227935 cites W2118571345 @default.
• W2623227935 cites W2123152720 @default.
• W2623227935 cites W2129558039 @default.
• W2623227935 cites W2150015168 @default.
• W2623227935 cites W2153245849 @default.
• W2623227935 cites W2157127485 @default.
• W2623227935 cites W2158819124 @default.
• W2623227935 cites W2159365557 @default.
• W2623227935 cites W2160170449 @default.
• W2623227935 cites W2161605421 @default.
• W2623227935 cites W2162416324 @default.
• W2623227935 cites W2164145855 @default.
• W2623227935 cites W2265804171 @default.
• W2623227935 cites W2320246267 @default.
• W2623227935 cites W2329692626 @default.
• W2623227935 doi "https://doi.org/10.1002/minf.201700031" @default.
• W2623227935 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28598557" @default.
• W2623227935 hasPublicationYear "2017" @default.
• W2623227935 type Work @default.
• W2623227935 sameAs 2623227935 @default.
• W2623227935 citedByCount "3" @default.
• W2623227935 countsByYear W26232279352018 @default.
• W2623227935 countsByYear W26232279352019 @default.
• W2623227935 countsByYear W26232279352021 @default.
• W2623227935 crossrefType "journal-article" @default.
• W2623227935 hasAuthorship W2623227935A5011858509 @default.
• W2623227935 hasAuthorship W2623227935A5017223512 @default.
• W2623227935 hasAuthorship W2623227935A5035266471 @default.
• W2623227935 hasAuthorship W2623227935A5052368521 @default.
• W2623227935 hasAuthorship W2623227935A5076288634 @default.
• W2623227935 hasConcept C104317684 @default.
• W2623227935 hasConcept C10679952 @default.
• W2623227935 hasConcept C11804247 @default.
• W2623227935 hasConcept C11960822 @default.
• W2623227935 hasConcept C12554922 @default.
• W2623227935 hasConcept C14036430 @default.
• W2623227935 hasConcept C147597530 @default.
• W2623227935 hasConcept C185592680 @default.
• W2623227935 hasConcept C2781196521 @default.
• W2623227935 hasConcept C2993175405 @default.
• W2623227935 hasConcept C55493867 @default.
• W2623227935 hasConcept C59593255 @default.
• W2623227935 hasConcept C6929976 @default.
• W2623227935 hasConcept C70721500 @default.
• W2623227935 hasConcept C86803240 @default.
• W2623227935 hasConcept C95444343 @default.
• W2623227935 hasConceptScore W2623227935C104317684 @default.

• next