Matches in SemOpenAlex for { <https://semopenalex.org/work/W2623263419> ?p ?o ?g. }
- W2623263419 endingPage "1165" @default.
- W2623263419 startingPage "1155" @default.
- W2623263419 abstract "Vascular smooth muscle cell (VSMC) migration and proliferation at sites of vascular injury are both critical steps in the development of intimal hyperplasia (IH). Local delivery of nitric oxide (NO) largely prevents these events. Among the NO donors, tetraazamacrocyclic nitrosyl complexes, such as trans-[Ru(NO)Cl(cyclam)](PF6 )2 (cyclamNO), gained attention for their features, which include the possibility of being embedded in solid matrices, and ability to participate in a nitrite/NO catalytic conversion cycle.Methods used to evaluate cyclamNO activity: safety margin by NR and MTT; cell proliferation by 3H-thymidine incorporation and proliferating cell nuclear antigen (PCNA) expression; antimigratory properties by transwell and wound healing; prevention of cell phenotypic switching under platelet-derived growth factor type BB (PDGF-BB) stimuli by analysis of alpha smooth muscle actin (α-SMA) expression.Cell proliferation and migration induced by PDGF-BB were significantly inhibited by cyclamNO. The ~60% reduction on expression of contractile protein α-SMA induced by PDGF-BB revealed VSMC phenotypic switching which is significantly prevented by cyclamNO. Compared to the NO donor sodium nitroprusside, cyclamNO showed to be significantly less cytotoxic.With great potential to maintain VSMC functionality and prevent IH-associated events, cyclamNO might be a promissory drug for several applications in cardiovascular medicine, as in stents." @default.
- W2623263419 created "2017-06-15" @default.
- W2623263419 creator A5003520626 @default.
- W2623263419 creator A5014439746 @default.
- W2623263419 creator A5023349336 @default.
- W2623263419 creator A5027371391 @default.
- W2623263419 date "2017-06-07" @default.
- W2623263419 modified "2023-10-15" @default.
- W2623263419 title "Phenotypic switching prevention and proliferation/migration inhibition of vascular smooth muscle cells by the ruthenium nitrosyl complex <i>trans</i>-[Ru(NO)Cl(cyclam](PF6)2" @default.
- W2623263419 cites W1527614413 @default.
- W2623263419 cites W176420385 @default.
- W2623263419 cites W1966192524 @default.
- W2623263419 cites W1967492538 @default.
- W2623263419 cites W1971377175 @default.
- W2623263419 cites W1972858609 @default.
- W2623263419 cites W1973824723 @default.
- W2623263419 cites W1980224151 @default.
- W2623263419 cites W1980458823 @default.
- W2623263419 cites W1982201293 @default.
- W2623263419 cites W1989786922 @default.
- W2623263419 cites W1993601025 @default.
- W2623263419 cites W1996147332 @default.
- W2623263419 cites W2006823334 @default.
- W2623263419 cites W2010296096 @default.
- W2623263419 cites W2010818369 @default.
- W2623263419 cites W2012367453 @default.
- W2623263419 cites W2013084035 @default.
- W2623263419 cites W2013104275 @default.
- W2623263419 cites W2020867943 @default.
- W2623263419 cites W2023275162 @default.
- W2623263419 cites W2024660473 @default.
- W2623263419 cites W2025725319 @default.
- W2623263419 cites W2026972928 @default.
- W2623263419 cites W2033357754 @default.
- W2623263419 cites W2041075406 @default.
- W2623263419 cites W2042399435 @default.
- W2623263419 cites W2042912687 @default.
- W2623263419 cites W2044087150 @default.
- W2623263419 cites W2048058951 @default.
- W2623263419 cites W2056020278 @default.
- W2623263419 cites W2059211217 @default.
- W2623263419 cites W2061946374 @default.
- W2623263419 cites W2067628141 @default.
- W2623263419 cites W2082272174 @default.
- W2623263419 cites W2094891357 @default.
- W2623263419 cites W2095916495 @default.
- W2623263419 cites W2096334465 @default.
- W2623263419 cites W2100592123 @default.
- W2623263419 cites W2112964143 @default.
- W2623263419 cites W2113684546 @default.
- W2623263419 cites W2116531075 @default.
- W2623263419 cites W2121822802 @default.
- W2623263419 cites W2129956169 @default.
- W2623263419 cites W2133090725 @default.
- W2623263419 cites W2135497215 @default.
- W2623263419 cites W2143293940 @default.
- W2623263419 cites W2155835199 @default.
- W2623263419 cites W2159811849 @default.
- W2623263419 cites W2170187489 @default.
- W2623263419 cites W2183745781 @default.
- W2623263419 cites W2232982083 @default.
- W2623263419 cites W2267941286 @default.
- W2623263419 cites W2305934227 @default.
- W2623263419 cites W2316902986 @default.
- W2623263419 cites W2330559915 @default.
- W2623263419 cites W2339699486 @default.
- W2623263419 cites W2469160399 @default.
- W2623263419 cites W2589490117 @default.
- W2623263419 cites W4232582339 @default.
- W2623263419 doi "https://doi.org/10.1111/jphp.12755" @default.
- W2623263419 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28590566" @default.
- W2623263419 hasPublicationYear "2017" @default.
- W2623263419 type Work @default.
- W2623263419 sameAs 2623263419 @default.
- W2623263419 citedByCount "8" @default.
- W2623263419 countsByYear W26232634192018 @default.
- W2623263419 countsByYear W26232634192019 @default.
- W2623263419 countsByYear W26232634192020 @default.
- W2623263419 countsByYear W26232634192021 @default.
- W2623263419 countsByYear W26232634192022 @default.
- W2623263419 crossrefType "journal-article" @default.
- W2623263419 hasAuthorship W2623263419A5003520626 @default.
- W2623263419 hasAuthorship W2623263419A5014439746 @default.
- W2623263419 hasAuthorship W2623263419A5023349336 @default.
- W2623263419 hasAuthorship W2623263419A5027371391 @default.
- W2623263419 hasConcept C134018914 @default.
- W2623263419 hasConcept C137738243 @default.
- W2623263419 hasConcept C1491633281 @default.
- W2623263419 hasConcept C153911025 @default.
- W2623263419 hasConcept C170493617 @default.
- W2623263419 hasConcept C180361614 @default.
- W2623263419 hasConcept C185592680 @default.
- W2623263419 hasConcept C2775960820 @default.
- W2623263419 hasConcept C2779395532 @default.
- W2623263419 hasConcept C2779610285 @default.
- W2623263419 hasConcept C29537977 @default.
- W2623263419 hasConcept C2992686903 @default.
- W2623263419 hasConcept C34688535 @default.