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- W2623277795 abstract "The bacterial and archaeal CRISPR-Cas systems of adaptive immunity show remarkable diversity of protein composition, effector complex structure, genome locus architecture and mechanisms of adaptation, pre-CRISPR (cr)RNA processing and interference. The CRISPR-Cas systems belong to two classes, with multi-subunit effector complexes in Class 1 and single-protein effector modules in Class 2. Concerted genomic and experimental efforts on comprehensive characterization of Class 2 CRISPR-Cas systems led to the identification of two new types and several subtypes. The newly characterized type VI systems are the first among the CRISPR-Cas variants to exclusively target RNA. Unexpectedly, in some of the class 2 systems, the effector protein is additionally responsible for the pre-crRNA processing. Comparative analysis of the effector complexes indicates that Class 2 systems evolved from mobile genetic elements on multiple, independent occasions." @default.
- W2623277795 created "2017-06-15" @default.
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- W2623277795 creator A5035240489 @default.
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- W2623277795 date "2017-06-01" @default.
- W2623277795 modified "2023-10-11" @default.
- W2623277795 title "Diversity, classification and evolution of CRISPR-Cas systems" @default.
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- W2623277795 doi "https://doi.org/10.1016/j.mib.2017.05.008" @default.
- W2623277795 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5776717" @default.
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