Matches in SemOpenAlex for { <https://semopenalex.org/work/W2623330179> ?p ?o ?g. }
- W2623330179 endingPage "e0179169" @default.
- W2623330179 startingPage "e0179169" @default.
- W2623330179 abstract "Class 1 integrons have played a major role in the global dissemination of antibiotic resistance. Reconstructing the history of class 1 integrons might help us control further spread of antibiotic resistance by understanding how human activities influence microbial evolution. Here we describe a class 1 integron that represents an intermediate stage in the evolutionary history of clinical integrons. It was embedded in a series of nested transposons, carried on an IncP plasmid resident in Enterobacter, isolated from the surface of baby spinach leaves. Based on the structure of this integron, we present a modified hypothesis for integron assembly, where the ancestral clinical class 1 integron was captured from a betaproteobacterial chromosome to form a Tn402-like transposon. This transposon then inserted into a plasmid-borne Tn21-like ancestor while in an environmental setting, possibly a bacterium resident in the phyllosphere. We suggest that the qacE gene cassette, conferring resistance to biocides, together with the mercury resistance operon carried by Tn21, provided a selective advantage when this bacterium made its way into the human commensal flora via food. The integron characterized here was located in Tn6007, which along with Tn6008, forms part of the larger Tn6006 transposon, itself inserted into another transposable element to form the Tn21-like transposon, Tn6005. This element has previously been described from the human microbiota, but with a promoter mutation that upregulates integron cassette expression. This element we describe here is from an environmental bacterium, and supports the hypothesis that the ancestral class 1 integron migrated into anthropogenic settings via foodstuffs. Selection pressures brought about by early antimicrobial agents, including mercury, arsenic and disinfectants, promoted its initial fixation, the acquisition of promoter mutations, and subsequent dissemination into various species and pathogens." @default.
- W2623330179 created "2017-06-15" @default.
- W2623330179 creator A5014384973 @default.
- W2623330179 creator A5055770757 @default.
- W2623330179 creator A5069432238 @default.
- W2623330179 creator A5077020521 @default.
- W2623330179 creator A5081713394 @default.
- W2623330179 date "2017-06-06" @default.
- W2623330179 modified "2023-10-17" @default.
- W2623330179 title "Evolution of class 1 integrons: Mobilization and dispersal via food-borne bacteria" @default.
- W2623330179 cites W1972469893 @default.
- W2623330179 cites W1975701682 @default.
- W2623330179 cites W1990524884 @default.
- W2623330179 cites W1994183353 @default.
- W2623330179 cites W1995954523 @default.
- W2623330179 cites W1995989835 @default.
- W2623330179 cites W1998258963 @default.
- W2623330179 cites W2008602286 @default.
- W2623330179 cites W2030941577 @default.
- W2623330179 cites W2035139729 @default.
- W2623330179 cites W2035657017 @default.
- W2623330179 cites W2050108888 @default.
- W2623330179 cites W2050116248 @default.
- W2623330179 cites W2058729834 @default.
- W2623330179 cites W2059624542 @default.
- W2623330179 cites W2067472717 @default.
- W2623330179 cites W2093471017 @default.
- W2623330179 cites W2097016077 @default.
- W2623330179 cites W2112010690 @default.
- W2623330179 cites W2113828015 @default.
- W2623330179 cites W2117802370 @default.
- W2623330179 cites W2125649845 @default.
- W2623330179 cites W2133490400 @default.
- W2623330179 cites W2136264360 @default.
- W2623330179 cites W2138811562 @default.
- W2623330179 cites W2144203006 @default.
- W2623330179 cites W2144656189 @default.
- W2623330179 cites W2145191698 @default.
- W2623330179 cites W2145463306 @default.
- W2623330179 cites W2155075136 @default.
- W2623330179 cites W2155623469 @default.
- W2623330179 cites W2158119633 @default.
- W2623330179 cites W2161755302 @default.
- W2623330179 cites W2163740188 @default.
- W2623330179 cites W2412233985 @default.
- W2623330179 cites W2528989351 @default.
- W2623330179 cites W2533645590 @default.
- W2623330179 cites W4235879813 @default.
- W2623330179 cites W848743766 @default.
- W2623330179 cites W85380906 @default.
- W2623330179 doi "https://doi.org/10.1371/journal.pone.0179169" @default.
- W2623330179 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5460862" @default.
- W2623330179 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28586403" @default.
- W2623330179 hasPublicationYear "2017" @default.
- W2623330179 type Work @default.
- W2623330179 sameAs 2623330179 @default.
- W2623330179 citedByCount "71" @default.
- W2623330179 countsByYear W26233301792017 @default.
- W2623330179 countsByYear W26233301792018 @default.
- W2623330179 countsByYear W26233301792019 @default.
- W2623330179 countsByYear W26233301792020 @default.
- W2623330179 countsByYear W26233301792021 @default.
- W2623330179 countsByYear W26233301792022 @default.
- W2623330179 countsByYear W26233301792023 @default.
- W2623330179 crossrefType "journal-article" @default.
- W2623330179 hasAuthorship W2623330179A5014384973 @default.
- W2623330179 hasAuthorship W2623330179A5055770757 @default.
- W2623330179 hasAuthorship W2623330179A5069432238 @default.
- W2623330179 hasAuthorship W2623330179A5077020521 @default.
- W2623330179 hasAuthorship W2623330179A5081713394 @default.
- W2623330179 hasBestOaLocation W26233301791 @default.
- W2623330179 hasConcept C10147152 @default.
- W2623330179 hasConcept C104317684 @default.
- W2623330179 hasConcept C141231307 @default.
- W2623330179 hasConcept C22744801 @default.
- W2623330179 hasConcept C2776650774 @default.
- W2623330179 hasConcept C4918238 @default.
- W2623330179 hasConcept C54355233 @default.
- W2623330179 hasConcept C86803240 @default.
- W2623330179 hasConcept C89423630 @default.
- W2623330179 hasConceptScore W2623330179C10147152 @default.
- W2623330179 hasConceptScore W2623330179C104317684 @default.
- W2623330179 hasConceptScore W2623330179C141231307 @default.
- W2623330179 hasConceptScore W2623330179C22744801 @default.
- W2623330179 hasConceptScore W2623330179C2776650774 @default.
- W2623330179 hasConceptScore W2623330179C4918238 @default.
- W2623330179 hasConceptScore W2623330179C54355233 @default.
- W2623330179 hasConceptScore W2623330179C86803240 @default.
- W2623330179 hasConceptScore W2623330179C89423630 @default.
- W2623330179 hasFunder F4320334704 @default.
- W2623330179 hasIssue "6" @default.
- W2623330179 hasLocation W26233301791 @default.
- W2623330179 hasLocation W26233301792 @default.
- W2623330179 hasLocation W26233301793 @default.
- W2623330179 hasLocation W26233301794 @default.
- W2623330179 hasOpenAccess W2623330179 @default.
- W2623330179 hasPrimaryLocation W26233301791 @default.
- W2623330179 hasRelatedWork W2026612772 @default.