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- W2623354905 abstract "Introduction: Waldenström’s macroglobulinemia (WM) is a rare, incurable B-cell lymphoma, with a median survival of 5–10 years in symptomatic patients. There is no consensus on the standard of care and several agents are currently used in these patients.Areas covered: In this article, we will review the use of standard therapies and new drugs investigated such as monoclonal antibodies, proteasome inhibitors, immunomodulatory agents, Bruton’s tyrosine kinase inhibitors and novel agents in early-stage development.Expert commentary: RCD (Rituximab/Cyclophosphamide/Dexamethasone) is an effective and safe treatment in first line in WM. BR (Bendamustine/Rituximab) or BRD (Bortezomib/Rituximab/Dexamethasone) provide durable responses, and are still indicated in most patients. Ibrutinib is a new option and it was approved as primary therapy and for relapse. Carfilzomib based therapy represents an emerging option for proteasome-inhibitor based therapy for WM. Despite encouraging results, WM remains an incurable disease; therefore, new treatment options are needed. For this reason, continued participation in clinical trials should be encouraged." @default.
- W2623354905 created "2017-06-15" @default.
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- W2623354905 date "2017-06-19" @default.
- W2623354905 modified "2023-10-14" @default.
- W2623354905 title "Current options to manage Waldenström’s macroglobulinemia" @default.
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- W2623354905 doi "https://doi.org/10.1080/17474086.2017.1339596" @default.
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