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- W2623356525 abstract "e12085 Background: Breast cancer is an increasingly treatable disease which means that many women will live a long time with the esthetic consequences of their treatment. The majority of women with early breast cancer are given whole breast external beam radiation therapy (EBRT) after lumpectomy (breast conservation). It has been demonstrated, using an objective assessment of esthetic outcome in patients from a randomized trial that “redness”, a surrogate for radiation induced erythema grade I or II, is significantly greater after one year in patients receiving EBRT compared with those receiving intraoperative radiation therapy (IORT). However, it has been observed that not all women given EBRT have detectable erythema, which implies that there is a greater variability in this group. In order to test this hypothesis a test of unequal group variances was performed. Methods: 991 frontal digital photographs were analyzed from women participating in the TARGIT A Trial (NCT00983684) at four sites (Lublin, Mannheim, Copenhagen and Perth). Photographs taken at baseline (before surgery), 1 and 2 years (after surgery and EBRT or IORT) were objectively assessed, blinded to treatment received, by BCCT.core software which produces overall Harris scores, and scores for various measures of symmetry, color and scar. The scores for color were analyzed in SAS v9.4 using PROC GLM. Results: cEMDL, a color score associated with lightness, showed significant heterogeneity of variance (using Levene's and Welch's Tests, p < 0.0001) in the women treated with EBRT, but not in those treated with IORT (p = 0.4). However, cX2b (associated with redness) showed significant heterogeneity of variance in both the EBRT and IORT treated groups (p < 0.0001), although the point estimates moved in different directions. Conclusions: This study demonstrates that there are complex changes in skin color following radiation therapy to the breast, and assumptions regarding homogeneity of variance should be checked if required by the statistical analysis." @default.
- W2623356525 created "2017-06-15" @default.
- W2623356525 creator A5060216513 @default.
- W2623356525 date "2017-05-20" @default.
- W2623356525 modified "2023-09-27" @default.
- W2623356525 title "Homogeneity of variance of measures associated with objective assessment of esthetic outcome after treatment with radiation therapy in early breast cancer." @default.
- W2623356525 doi "https://doi.org/10.1200/jco.2017.35.15_suppl.e12085" @default.
- W2623356525 hasPublicationYear "2017" @default.
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