Matches in SemOpenAlex for { <https://semopenalex.org/work/W2623365412> ?p ?o ?g. }
Showing items 1 to 97 of
97
with 100 items per page.
- W2623365412 endingPage "278" @default.
- W2623365412 startingPage "269" @default.
- W2623365412 abstract "The aim of this study was to establish a procedure for blood progenitor cell graft processing in rats. As a first step the mobilization protocol was optimized. The second step was dedicated to define the optimal source for subsequent graft manufacturing: either peripheral blood or spleen. The third step was designed to establish a protocol for purification of stem cells. The best mobilization results in terms of white blood cell count, granulocyte colony forming units (CFUG) and CD90 positive progenitor cells were obtained after pre-treatment of the donors for 5 days with recombinant human granulocyte colony stimulating factor (100 I¼g/kg) in combination with murine stem cell factor (33 I¼g/kg). Splenectomy prior to mobilization increased the yield of stem cells from peripheral blood. The numbers of CD90-positive progenitor cells recovered from the spleen of one rat after stem cell mobilization were sufficient to generate one stem cell graft. Grafts containing 1 x 106 progenitor cells – and thus sufficient for transplantation - were obtained after Tcell depletion and positive selection of CD90 positive cells. The grafts were characterized and showed a purity exceeding 70%, a T-cell depletion of 3.6 log10 and a 3-fold increase in CFU-G compared to the yield post mobilization.Â" @default.
- W2623365412 created "2017-06-15" @default.
- W2623365412 creator A5008940140 @default.
- W2623365412 creator A5020116063 @default.
- W2623365412 creator A5027835055 @default.
- W2623365412 creator A5039214888 @default.
- W2623365412 creator A5059338299 @default.
- W2623365412 creator A5077872934 @default.
- W2623365412 creator A5086200590 @default.
- W2623365412 date "2007-01-01" @default.
- W2623365412 modified "2023-09-27" @default.
- W2623365412 title "Peripheral Progenitor Cell Graft in the Rat: A Technique of Graft Processing" @default.
- W2623365412 hasPublicationYear "2007" @default.
- W2623365412 type Work @default.
- W2623365412 sameAs 2623365412 @default.
- W2623365412 citedByCount "0" @default.
- W2623365412 crossrefType "journal-article" @default.
- W2623365412 hasAuthorship W2623365412A5008940140 @default.
- W2623365412 hasAuthorship W2623365412A5020116063 @default.
- W2623365412 hasAuthorship W2623365412A5027835055 @default.
- W2623365412 hasAuthorship W2623365412A5039214888 @default.
- W2623365412 hasAuthorship W2623365412A5059338299 @default.
- W2623365412 hasAuthorship W2623365412A5077872934 @default.
- W2623365412 hasAuthorship W2623365412A5086200590 @default.
- W2623365412 hasConcept C10205521 @default.
- W2623365412 hasConcept C116716535 @default.
- W2623365412 hasConcept C141071460 @default.
- W2623365412 hasConcept C156708679 @default.
- W2623365412 hasConcept C15729860 @default.
- W2623365412 hasConcept C16685009 @default.
- W2623365412 hasConcept C166957645 @default.
- W2623365412 hasConcept C192285135 @default.
- W2623365412 hasConcept C201750760 @default.
- W2623365412 hasConcept C203014093 @default.
- W2623365412 hasConcept C2776694085 @default.
- W2623365412 hasConcept C2777767877 @default.
- W2623365412 hasConcept C2777983669 @default.
- W2623365412 hasConcept C2780931953 @default.
- W2623365412 hasConcept C28328180 @default.
- W2623365412 hasConcept C2911091166 @default.
- W2623365412 hasConcept C523546767 @default.
- W2623365412 hasConcept C54355233 @default.
- W2623365412 hasConcept C71924100 @default.
- W2623365412 hasConcept C86803240 @default.
- W2623365412 hasConcept C95444343 @default.
- W2623365412 hasConcept C95457728 @default.
- W2623365412 hasConceptScore W2623365412C10205521 @default.
- W2623365412 hasConceptScore W2623365412C116716535 @default.
- W2623365412 hasConceptScore W2623365412C141071460 @default.
- W2623365412 hasConceptScore W2623365412C156708679 @default.
- W2623365412 hasConceptScore W2623365412C15729860 @default.
- W2623365412 hasConceptScore W2623365412C16685009 @default.
- W2623365412 hasConceptScore W2623365412C166957645 @default.
- W2623365412 hasConceptScore W2623365412C192285135 @default.
- W2623365412 hasConceptScore W2623365412C201750760 @default.
- W2623365412 hasConceptScore W2623365412C203014093 @default.
- W2623365412 hasConceptScore W2623365412C2776694085 @default.
- W2623365412 hasConceptScore W2623365412C2777767877 @default.
- W2623365412 hasConceptScore W2623365412C2777983669 @default.
- W2623365412 hasConceptScore W2623365412C2780931953 @default.
- W2623365412 hasConceptScore W2623365412C28328180 @default.
- W2623365412 hasConceptScore W2623365412C2911091166 @default.
- W2623365412 hasConceptScore W2623365412C523546767 @default.
- W2623365412 hasConceptScore W2623365412C54355233 @default.
- W2623365412 hasConceptScore W2623365412C71924100 @default.
- W2623365412 hasConceptScore W2623365412C86803240 @default.
- W2623365412 hasConceptScore W2623365412C95444343 @default.
- W2623365412 hasConceptScore W2623365412C95457728 @default.
- W2623365412 hasIssue "4" @default.
- W2623365412 hasOpenAccess W2623365412 @default.
- W2623365412 hasRelatedWork W1537330558 @default.
- W2623365412 hasRelatedWork W1969701393 @default.
- W2623365412 hasRelatedWork W1999064157 @default.
- W2623365412 hasRelatedWork W2015963921 @default.
- W2623365412 hasRelatedWork W2017235265 @default.
- W2623365412 hasRelatedWork W2028536309 @default.
- W2623365412 hasRelatedWork W2053947868 @default.
- W2623365412 hasRelatedWork W2064440568 @default.
- W2623365412 hasRelatedWork W2072935452 @default.
- W2623365412 hasRelatedWork W2078611597 @default.
- W2623365412 hasRelatedWork W2133476536 @default.
- W2623365412 hasRelatedWork W2396455726 @default.
- W2623365412 hasRelatedWork W2397788246 @default.
- W2623365412 hasRelatedWork W2411295760 @default.
- W2623365412 hasRelatedWork W2417049717 @default.
- W2623365412 hasRelatedWork W261082544 @default.
- W2623365412 hasRelatedWork W2986070722 @default.
- W2623365412 hasRelatedWork W3199434 @default.
- W2623365412 hasRelatedWork W330534431 @default.
- W2623365412 hasRelatedWork W2492413108 @default.
- W2623365412 hasVolume "34" @default.
- W2623365412 isParatext "false" @default.
- W2623365412 isRetracted "false" @default.
- W2623365412 magId "2623365412" @default.
- W2623365412 workType "article" @default.