Matches in SemOpenAlex for { <https://semopenalex.org/work/W2623482004> ?p ?o ?g. }
- W2623482004 endingPage "2366" @default.
- W2623482004 startingPage "2356" @default.
- W2623482004 abstract "The initial treatment of haemodynamically stable patients with pulmonary embolism (PE) has dramatically changed since the introduction of low molecular weight heparins (LMWHs). With the recent discovery of the direct oral anticoagulant drugs (DOACs), initial treatment of PE will be simplified even further. In several large clinical trials it has been demonstrated that DOACs are not inferior to standard therapy for the initial treatment of PE, and because of their practicability they are becoming the agents of first choice. However, many relative contraindications to DOACs were exclusion criteria in the clinical trials. Therefore, LMWHs will continue to play an important role in initial PE treatment and in some cases there still is a role for unfractionated heparin (UFH). In this review we will give an overview of the biophysical, pharmacokinetic and pharmacodynamic properties of anticoagulants currently available for the initial management of PE. In addition, we will provide a comprehensive overview of the indications for the use of UFH, LMWHs and DOACs in the initial management of PE from a pharmacokinetic/‐dynamic point of view." @default.
- W2623482004 created "2017-06-15" @default.
- W2623482004 creator A5031526510 @default.
- W2623482004 creator A5038173763 @default.
- W2623482004 creator A5043315520 @default.
- W2623482004 creator A5056247058 @default.
- W2623482004 creator A5081719218 @default.
- W2623482004 date "2017-07-09" @default.
- W2623482004 modified "2023-10-01" @default.
- W2623482004 title "Initial anticoagulation in patients with pulmonary embolism: thrombolysis, unfractionated heparin, LMWH, fondaparinux, or DOACs?" @default.
- W2623482004 cites W1488133965 @default.
- W2623482004 cites W1497480648 @default.
- W2623482004 cites W1584368083 @default.
- W2623482004 cites W1592091620 @default.
- W2623482004 cites W1641613989 @default.
- W2623482004 cites W1707171754 @default.
- W2623482004 cites W1829866114 @default.
- W2623482004 cites W1972938090 @default.
- W2623482004 cites W1973233314 @default.
- W2623482004 cites W1975926268 @default.
- W2623482004 cites W1976527118 @default.
- W2623482004 cites W1976693613 @default.
- W2623482004 cites W1984833612 @default.
- W2623482004 cites W1986451071 @default.
- W2623482004 cites W1992602391 @default.
- W2623482004 cites W1999388432 @default.
- W2623482004 cites W1999668293 @default.
- W2623482004 cites W2000006816 @default.
- W2623482004 cites W2000576592 @default.
- W2623482004 cites W2001027084 @default.
- W2623482004 cites W2001564318 @default.
- W2623482004 cites W2002635586 @default.
- W2623482004 cites W2006868468 @default.
- W2623482004 cites W2008614204 @default.
- W2623482004 cites W2010481138 @default.
- W2623482004 cites W2013564192 @default.
- W2623482004 cites W2015057125 @default.
- W2623482004 cites W2016611112 @default.
- W2623482004 cites W2017582897 @default.
- W2623482004 cites W2017980490 @default.
- W2623482004 cites W2020900565 @default.
- W2623482004 cites W2028577342 @default.
- W2623482004 cites W2030528634 @default.
- W2623482004 cites W2031848422 @default.
- W2623482004 cites W2034926285 @default.
- W2623482004 cites W2036466779 @default.
- W2623482004 cites W2039337035 @default.
- W2623482004 cites W2044459782 @default.
- W2623482004 cites W2046497484 @default.
- W2623482004 cites W2050683323 @default.
- W2623482004 cites W2054730686 @default.
- W2623482004 cites W2068020208 @default.
- W2623482004 cites W2069565722 @default.
- W2623482004 cites W2069773373 @default.
- W2623482004 cites W2070112905 @default.
- W2623482004 cites W2075196907 @default.
- W2623482004 cites W2083413727 @default.
- W2623482004 cites W2087002320 @default.
- W2623482004 cites W2087368566 @default.
- W2623482004 cites W2091576403 @default.
- W2623482004 cites W2092181626 @default.
- W2623482004 cites W2098215452 @default.
- W2623482004 cites W2099974623 @default.
- W2623482004 cites W2106528571 @default.
- W2623482004 cites W2110134277 @default.
- W2623482004 cites W2115819752 @default.
- W2623482004 cites W2118092611 @default.
- W2623482004 cites W2119531959 @default.
- W2623482004 cites W2119622751 @default.
- W2623482004 cites W2121477490 @default.
- W2623482004 cites W2124882231 @default.
- W2623482004 cites W2127185770 @default.
- W2623482004 cites W2134908914 @default.
- W2623482004 cites W2136489990 @default.
- W2623482004 cites W2137975307 @default.
- W2623482004 cites W2138321048 @default.
- W2623482004 cites W2138438886 @default.
- W2623482004 cites W2144169464 @default.
- W2623482004 cites W2147406493 @default.
- W2623482004 cites W2148024777 @default.
- W2623482004 cites W2148312520 @default.
- W2623482004 cites W2152914954 @default.
- W2623482004 cites W2158255752 @default.
- W2623482004 cites W2159007980 @default.
- W2623482004 cites W2159553511 @default.
- W2623482004 cites W2160625453 @default.
- W2623482004 cites W2169845753 @default.
- W2623482004 cites W2180762426 @default.
- W2623482004 cites W2189963137 @default.
- W2623482004 cites W2194756172 @default.
- W2623482004 cites W2196064518 @default.
- W2623482004 cites W2198918485 @default.
- W2623482004 cites W2225937646 @default.
- W2623482004 cites W2253704389 @default.
- W2623482004 cites W2294219585 @default.
- W2623482004 cites W2330454673 @default.
- W2623482004 cites W2340768556 @default.
- W2623482004 cites W2514338974 @default.