Matches in SemOpenAlex for { <https://semopenalex.org/work/W2623486537> ?p ?o ?g. }
- W2623486537 endingPage "277" @default.
- W2623486537 startingPage "265" @default.
- W2623486537 abstract "Narcolepsy is the most well-characterized hypersomnia in both clinical and basic research fields. Narcolepsy is caused by degeneration of hypocretin-producing neurons in the hypothalamus. Although hypocretin receptor antagonists have been developed as sleep-inducing drugs, a high dose of suvorexant, a hypocretin receptor antagonist, inhibits gene expression of prepro-hypocretin to induce narcoleptic attack in wild-type mice. Prostaglandin D2 is the most potent endogenous sleep-promoting substance. Overproduction of prostaglandin D2 is involved in hypersomnia in patients with mastocytosis and African sleeping sickness or in mice after a pentylenetetrazole-induced seizure. Commercialized sleep-promoting supplements also may induce hypersomnia in humans." @default.
- W2623486537 created "2017-06-15" @default.
- W2623486537 creator A5060772179 @default.
- W2623486537 date "2017-09-01" @default.
- W2623486537 modified "2023-10-18" @default.
- W2623486537 title "Neurobiological Basis of Hypersomnia" @default.
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