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- W2623501182 abstract "Background: Intra operative radiation therapy (IORT) is a cancer treatment modality combining surgery and radiation therapy that permits the delivery of a large single dose of radiation at the time of the tumour resection. During the last years, IORT has become a widespread technique in clinical routine. This was possible thanks to the recent development of small dedicated, and hence very flexible, electron accelerators suitable for a surgical operation environment. However, the electron beams produced by these dedicated linacs are different with respect to those produced by linacs used in conventional radiation therapy in terms of dose rate (dose delivered/time of irradiation), dose per pulse (dose delivered per emitted beam pulse) and energy spectrum. In particular the very high dose rate and dose per pulse (i.e., respectively about 20 and 100 times greater than those of conventional radiation therapy) pose some radiobiological questions that have not yet been fully investigated. The aim of this work was to evaluate the relative biological effectiveness (RBE) of the IORT beams through the experimental construction of dose-response curves for cell survival." @default.
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- W2623501182 date "2017-07-01" @default.
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- W2623501182 title "Radiobiological characterization of the very high dose rate and dose per pulse electron beams produced by an IORT (intra operative radiation therapy) dedicated linac" @default.
- W2623501182 doi "https://doi.org/10.21037/tcr.2017.05.21" @default.
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