Matches in SemOpenAlex for { <https://semopenalex.org/work/W2623582436> ?p ?o ?g. }
- W2623582436 endingPage "467" @default.
- W2623582436 startingPage "443" @default.
- W2623582436 abstract "Non-alcoholic fatty liver disease (NAFLD) is in parallel with the obesity epidemic and it is the most common cause of liver diseases. The development of hepatic steatosis in majority of patients is linked to dietary fat ingestion. NAFLD is characterized by excess accumulation of triglyceride in the hepatocyte due to both increased inflow of free fatty acids and de novo hepatic lipogenesis. Insulin resistance with the deficiency of insulin receptor substrate-2 (IRS-2)-associated phosphatidylinositol 3-kinase (PI3K) activity causes an increase in intracellular fatty acid-derived metabolites such as diacylglycerol, fatty acyl CoA or ceramides. Lipotoxicity-related mechanism of NAFLD could be explained still best by the double-hit hypothesis. Insulin resistance is the major mechanism in the development and progression of NAFLD/Non-alcoholic steatohepatitis (NASH). Metabolic oxidative stress, autophagy, and inflammation induce NASH progression. In the first hit the hepatic concentrations of diacylglycerol increase with rising saturated liver fat content in human NAFLD. Activities of mitochondrial respiratory chain complexes are decreased in liver tissue of patients with NASH. Furthermore, hepatocyte lipoapoptosis is a critical feature of NASH. In second hit reduced glutathione levels due to oxidative stress lead to overactivation of c-Jun N-terminal kinase (JNK)/c-Jun signaling that induces cell death in the steatotic liver. Accumulation of toxic levels of reactive oxygen species (ROS) is caused by the ineffectual cycling of the endoplasmic reticulum (ER) oxidoreductin (Ero1)-protein disulfide isomerase oxidation cycle through the downstream of the inner membrane mitochondrial oxidative metabolism and Kelch like-ECH-associated protein 1 (Keap1)- Nuclear factor (erythroid-derived 2)-like 2 (Nrf2) pathway." @default.
- W2623582436 created "2017-06-15" @default.
- W2623582436 creator A5026671889 @default.
- W2623582436 date "2017-01-01" @default.
- W2623582436 modified "2023-10-18" @default.
- W2623582436 title "Non-Alcoholic Fatty Liver Disease" @default.
- W2623582436 cites W131445839 @default.
- W2623582436 cites W144454424 @default.
- W2623582436 cites W1502813670 @default.
- W2623582436 cites W1543554758 @default.
- W2623582436 cites W1563504653 @default.
- W2623582436 cites W1622799587 @default.
- W2623582436 cites W1765719311 @default.
- W2623582436 cites W1792257846 @default.
- W2623582436 cites W182006361 @default.
- W2623582436 cites W1832095457 @default.
- W2623582436 cites W1849821171 @default.
- W2623582436 cites W1923086194 @default.
- W2623582436 cites W1965071591 @default.
- W2623582436 cites W1965129178 @default.
- W2623582436 cites W1965646051 @default.
- W2623582436 cites W1965727325 @default.
- W2623582436 cites W1966452335 @default.
- W2623582436 cites W1968940692 @default.
- W2623582436 cites W1972744939 @default.
- W2623582436 cites W1974152703 @default.
- W2623582436 cites W1975189993 @default.
- W2623582436 cites W1975610756 @default.
- W2623582436 cites W1975808053 @default.
- W2623582436 cites W1976094170 @default.
- W2623582436 cites W1976391651 @default.
- W2623582436 cites W1979443397 @default.
- W2623582436 cites W1979556656 @default.
- W2623582436 cites W1980050556 @default.
- W2623582436 cites W1980992924 @default.
- W2623582436 cites W1981708660 @default.
- W2623582436 cites W1982536531 @default.
- W2623582436 cites W1982578021 @default.
- W2623582436 cites W1984486531 @default.
- W2623582436 cites W1985538633 @default.
- W2623582436 cites W1985592156 @default.
- W2623582436 cites W1986060421 @default.
- W2623582436 cites W1986257201 @default.
- W2623582436 cites W1987934823 @default.
- W2623582436 cites W1989847959 @default.
- W2623582436 cites W1989908272 @default.
- W2623582436 cites W1991477890 @default.
- W2623582436 cites W1992915912 @default.
- W2623582436 cites W1993266217 @default.
- W2623582436 cites W1996688175 @default.
- W2623582436 cites W1997317586 @default.
- W2623582436 cites W1998265194 @default.
- W2623582436 cites W1999617321 @default.
- W2623582436 cites W2000349524 @default.
- W2623582436 cites W2001940599 @default.
- W2623582436 cites W2006838809 @default.
- W2623582436 cites W2007505836 @default.
- W2623582436 cites W2010250072 @default.
- W2623582436 cites W2013157141 @default.
- W2623582436 cites W2014980326 @default.
- W2623582436 cites W2015392958 @default.
- W2623582436 cites W2015450018 @default.
- W2623582436 cites W2016617561 @default.
- W2623582436 cites W2017168681 @default.
- W2623582436 cites W2019192392 @default.
- W2623582436 cites W2020242068 @default.
- W2623582436 cites W2020799782 @default.
- W2623582436 cites W2022657181 @default.
- W2623582436 cites W2022982729 @default.
- W2623582436 cites W2024851295 @default.
- W2623582436 cites W2025242285 @default.
- W2623582436 cites W2025511820 @default.
- W2623582436 cites W2025607561 @default.
- W2623582436 cites W2026241394 @default.
- W2623582436 cites W2026589609 @default.
- W2623582436 cites W2027115724 @default.
- W2623582436 cites W2028279477 @default.
- W2623582436 cites W2031293873 @default.
- W2623582436 cites W2034200174 @default.
- W2623582436 cites W2034298464 @default.
- W2623582436 cites W2036097574 @default.
- W2623582436 cites W2037591273 @default.
- W2623582436 cites W2039603705 @default.
- W2623582436 cites W2039890062 @default.
- W2623582436 cites W204032585 @default.
- W2623582436 cites W2040962503 @default.
- W2623582436 cites W2042033533 @default.
- W2623582436 cites W2047517132 @default.
- W2623582436 cites W2048375374 @default.
- W2623582436 cites W2048613643 @default.
- W2623582436 cites W2050675551 @default.
- W2623582436 cites W2050972261 @default.
- W2623582436 cites W2052153027 @default.
- W2623582436 cites W2052395914 @default.
- W2623582436 cites W2052701666 @default.
- W2623582436 cites W2053150532 @default.
- W2623582436 cites W2053307994 @default.
- W2623582436 cites W2053470799 @default.