Matches in SemOpenAlex for { <https://semopenalex.org/work/W2623592385> ?p ?o ?g. }
- W2623592385 abstract "Abstract Several growth factors, cytokines, hormones activate PI3K/Akt pathway. Akt is a key node in this pathway and activates different downstream paths. One such path is Akt/mTORC1/S6K1 that controls protein synthesis, cell survival, and proliferation. Here we show that a negative feedback controls activation of S6K1 through this pathway. Due to this negative feedback, a sustained phospho-Akt signal generates a transient pulse of phospho-S6K1. We have created a mathematical model for this circuit. Analysis of this model shows that the negative feedback acts as a filter and preferentially allows a signal, with sharp and faster rise of phospho-Akt, to induce pronounced activation of S6K1. It blocks an input with a fast oscillation of phospho-Akt to flow through this path. We show that this negative feedback leads to differential activation of S6K1 by Insulin and Insulin-like Growth Factor 1. Such differential effect may explain the difference in the mitogenic effect of these two molecules." @default.
- W2623592385 created "2017-06-15" @default.
- W2623592385 creator A5051880106 @default.
- W2623592385 creator A5059093825 @default.
- W2623592385 creator A5085862689 @default.
- W2623592385 date "2017-06-08" @default.
- W2623592385 modified "2023-09-23" @default.
- W2623592385 title "A Negative Feedback Regulates The Flow Of Signal Through Akt/mTORC1/S6K1 Pathway" @default.
- W2623592385 cites W1775749144 @default.
- W2623592385 cites W179416411 @default.
- W2623592385 cites W1804602290 @default.
- W2623592385 cites W1965435094 @default.
- W2623592385 cites W1974743726 @default.
- W2623592385 cites W1975444080 @default.
- W2623592385 cites W1980923443 @default.
- W2623592385 cites W1980940261 @default.
- W2623592385 cites W1984621921 @default.
- W2623592385 cites W1988737089 @default.
- W2623592385 cites W1992182416 @default.
- W2623592385 cites W1995242599 @default.
- W2623592385 cites W1995819749 @default.
- W2623592385 cites W1996861095 @default.
- W2623592385 cites W2002226709 @default.
- W2623592385 cites W2005693445 @default.
- W2623592385 cites W2007215370 @default.
- W2623592385 cites W2008282782 @default.
- W2623592385 cites W2010422325 @default.
- W2623592385 cites W2012001954 @default.
- W2623592385 cites W2020931266 @default.
- W2623592385 cites W2021380963 @default.
- W2623592385 cites W2024475905 @default.
- W2623592385 cites W2024696581 @default.
- W2623592385 cites W2026037773 @default.
- W2623592385 cites W2030945597 @default.
- W2623592385 cites W2031655911 @default.
- W2623592385 cites W2032511861 @default.
- W2623592385 cites W2047392189 @default.
- W2623592385 cites W2051091678 @default.
- W2623592385 cites W2062030505 @default.
- W2623592385 cites W2062860025 @default.
- W2623592385 cites W2070102480 @default.
- W2623592385 cites W2074377887 @default.
- W2623592385 cites W2075465392 @default.
- W2623592385 cites W2087835012 @default.
- W2623592385 cites W2095216640 @default.
- W2623592385 cites W2099540110 @default.
- W2623592385 cites W2101572834 @default.
- W2623592385 cites W2107186290 @default.
- W2623592385 cites W2109533749 @default.
- W2623592385 cites W2123973944 @default.
- W2623592385 cites W2129585918 @default.
- W2623592385 cites W2140484696 @default.
- W2623592385 cites W2150317682 @default.
- W2623592385 cites W2160079255 @default.
- W2623592385 cites W2166307667 @default.
- W2623592385 cites W2179083909 @default.
- W2623592385 cites W2345836671 @default.
- W2623592385 cites W2570914713 @default.
- W2623592385 cites W2593083251 @default.
- W2623592385 cites W4232790544 @default.
- W2623592385 cites W751952818 @default.
- W2623592385 doi "https://doi.org/10.1101/147710" @default.
- W2623592385 hasPublicationYear "2017" @default.
- W2623592385 type Work @default.
- W2623592385 sameAs 2623592385 @default.
- W2623592385 citedByCount "0" @default.
- W2623592385 crossrefType "posted-content" @default.
- W2623592385 hasAuthorship W2623592385A5051880106 @default.
- W2623592385 hasAuthorship W2623592385A5059093825 @default.
- W2623592385 hasAuthorship W2623592385A5085862689 @default.
- W2623592385 hasBestOaLocation W26235923851 @default.
- W2623592385 hasConcept C104202773 @default.
- W2623592385 hasConcept C119599485 @default.
- W2623592385 hasConcept C121332964 @default.
- W2623592385 hasConcept C127413603 @default.
- W2623592385 hasConcept C165801399 @default.
- W2623592385 hasConcept C166501922 @default.
- W2623592385 hasConcept C185592680 @default.
- W2623592385 hasConcept C62478195 @default.
- W2623592385 hasConcept C62520636 @default.
- W2623592385 hasConcept C75217442 @default.
- W2623592385 hasConcept C86554907 @default.
- W2623592385 hasConcept C86803240 @default.
- W2623592385 hasConcept C93586867 @default.
- W2623592385 hasConcept C95444343 @default.
- W2623592385 hasConcept C98490376 @default.
- W2623592385 hasConceptScore W2623592385C104202773 @default.
- W2623592385 hasConceptScore W2623592385C119599485 @default.
- W2623592385 hasConceptScore W2623592385C121332964 @default.
- W2623592385 hasConceptScore W2623592385C127413603 @default.
- W2623592385 hasConceptScore W2623592385C165801399 @default.
- W2623592385 hasConceptScore W2623592385C166501922 @default.
- W2623592385 hasConceptScore W2623592385C185592680 @default.
- W2623592385 hasConceptScore W2623592385C62478195 @default.
- W2623592385 hasConceptScore W2623592385C62520636 @default.
- W2623592385 hasConceptScore W2623592385C75217442 @default.
- W2623592385 hasConceptScore W2623592385C86554907 @default.
- W2623592385 hasConceptScore W2623592385C86803240 @default.
- W2623592385 hasConceptScore W2623592385C93586867 @default.
- W2623592385 hasConceptScore W2623592385C95444343 @default.