Matches in SemOpenAlex for { <https://semopenalex.org/work/W2623783389> ?p ?o ?g. }
- W2623783389 endingPage "779" @default.
- W2623783389 startingPage "769" @default.
- W2623783389 abstract "An efficacious malaria vaccine is necessary to advance the current control measures towards malaria elimination. To-date, only RTS,S/AS01, a leading pre-erythrocytic stage vaccine completed phase 3 trials, but with an efficacy of 28-36% in children, and 18-26% in infants, that waned over time. Blood-stage malaria vaccines protect against disease, and are considered effective targets for the logical design of next generation vaccines to improve the RTS,S field efficacy. Therefore, novel blood-stage vaccine candidate discovery efforts are critical, albeit with several challenges including, high polymorphisms in vaccine antigens, poor understanding of targets of naturally protective immunity, and difficulties in the expression of high AT-rich plasmodial proteins. Areas covered: PubMed ( www.ncbi.nlm.nih.gov/pubmed ) was searched to review the progress and future prospects of malaria vaccine research and development. We focused on post-genome vaccine candidate discovery, malaria vaccine development, sequence diversity, pre-clinical and clinical trials. Expert commentary: Post-genome high-throughput technologies using wheat germ cell-free protein synthesis technology and immuno-profiling with sera from malaria patients with clearly defined outcomes are highlighted to overcome current challenges of malaria vaccine candidate discovery." @default.
- W2623783389 created "2017-06-15" @default.
- W2623783389 creator A5003487307 @default.
- W2623783389 creator A5044197874 @default.
- W2623783389 creator A5059491151 @default.
- W2623783389 creator A5066528261 @default.
- W2623783389 creator A5072345714 @default.
- W2623783389 creator A5081815480 @default.
- W2623783389 date "2017-06-19" @default.
- W2623783389 modified "2023-10-14" @default.
- W2623783389 title "Blood-stage malaria vaccines: post-genome strategies for the identification of novel vaccine candidates" @default.
- W2623783389 cites W1537342340 @default.
- W2623783389 cites W1729017034 @default.
- W2623783389 cites W1761012009 @default.
- W2623783389 cites W1761021735 @default.
- W2623783389 cites W1817614869 @default.
- W2623783389 cites W190349426 @default.
- W2623783389 cites W1965139568 @default.
- W2623783389 cites W1968378375 @default.
- W2623783389 cites W1969689914 @default.
- W2623783389 cites W1972073650 @default.
- W2623783389 cites W1973488341 @default.
- W2623783389 cites W1973835029 @default.
- W2623783389 cites W1974245401 @default.
- W2623783389 cites W1977086234 @default.
- W2623783389 cites W1979147958 @default.
- W2623783389 cites W1979346865 @default.
- W2623783389 cites W1984080130 @default.
- W2623783389 cites W1984796152 @default.
- W2623783389 cites W1985878579 @default.
- W2623783389 cites W1994077336 @default.
- W2623783389 cites W1996862183 @default.
- W2623783389 cites W2000695993 @default.
- W2623783389 cites W2002932555 @default.
- W2623783389 cites W2008924331 @default.
- W2623783389 cites W2012593576 @default.
- W2623783389 cites W2016746408 @default.
- W2623783389 cites W2019851585 @default.
- W2623783389 cites W2026745968 @default.
- W2623783389 cites W2028671643 @default.
- W2623783389 cites W2034926863 @default.
- W2623783389 cites W2035169581 @default.
- W2623783389 cites W2036558143 @default.
- W2623783389 cites W2037225366 @default.
- W2623783389 cites W2037606550 @default.
- W2623783389 cites W2039242962 @default.
- W2623783389 cites W2039735909 @default.
- W2623783389 cites W2043891526 @default.
- W2623783389 cites W2046866639 @default.
- W2623783389 cites W2051809585 @default.
- W2623783389 cites W2052688453 @default.
- W2623783389 cites W2054621277 @default.
- W2623783389 cites W2057319782 @default.
- W2623783389 cites W2058406245 @default.
- W2623783389 cites W2060028595 @default.
- W2623783389 cites W2067908772 @default.
- W2623783389 cites W2079098638 @default.
- W2623783389 cites W2083385879 @default.
- W2623783389 cites W2085055383 @default.
- W2623783389 cites W2085684878 @default.
- W2623783389 cites W2087490172 @default.
- W2623783389 cites W2088693235 @default.
- W2623783389 cites W2088822039 @default.
- W2623783389 cites W2090205689 @default.
- W2623783389 cites W2090211342 @default.
- W2623783389 cites W2093426037 @default.
- W2623783389 cites W2099838559 @default.
- W2623783389 cites W2102131955 @default.
- W2623783389 cites W2113442583 @default.
- W2623783389 cites W2116741676 @default.
- W2623783389 cites W2119076403 @default.
- W2623783389 cites W2119855808 @default.
- W2623783389 cites W2123005998 @default.
- W2623783389 cites W2125264382 @default.
- W2623783389 cites W2128319492 @default.
- W2623783389 cites W2130386606 @default.
- W2623783389 cites W2137171250 @default.
- W2623783389 cites W2142248377 @default.
- W2623783389 cites W2142384652 @default.
- W2623783389 cites W2142545346 @default.
- W2623783389 cites W2144296388 @default.
- W2623783389 cites W2146205686 @default.
- W2623783389 cites W2148954648 @default.
- W2623783389 cites W2153756387 @default.
- W2623783389 cites W2154074344 @default.
- W2623783389 cites W2155827721 @default.
- W2623783389 cites W2156049957 @default.
- W2623783389 cites W2157905250 @default.
- W2623783389 cites W2159204717 @default.
- W2623783389 cites W2162315014 @default.
- W2623783389 cites W2162684905 @default.
- W2623783389 cites W2165626262 @default.
- W2623783389 cites W2166902938 @default.
- W2623783389 cites W2168341480 @default.
- W2623783389 cites W2168741095 @default.
- W2623783389 cites W2169030260 @default.
- W2623783389 cites W2174108569 @default.
- W2623783389 cites W2175263917 @default.