FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2623796402> ?p ?o ?g. }

• W2623796402 endingPage "1668" @default.
• W2623796402 startingPage "1658" @default.
• W2623796402 abstract "Although quantitative PCR (qPCR) has been explored for chimerism monitoring after allogeneic stem cell transplantation (SCT), evidence regarding its clinical utility compared with standard short tandem repeat (STR) is still limited. We retrospectively studied commercial qPCR and STR chimerism with respective positivity thresholds of .1% and 1% in 359 peripheral blood (PB) and 95 bone marrow (BM) samples from 30 adult patients after first HLA-matched SCT for myeloid malignancies or acute lymphatic leukemia. Concordance between the 2 methods was 79.5%, with all discordant samples positive in qPCR but negative in STR. Of the latter, sporadic qPCR positivity without clinical correlates was seen mostly in BM samples early post-transplant. In 7 of 21 patients with available follow-up samples in the first months after transplantation, qPCR but not STR revealed low levels (<1%) of sustained host chimerism in PB, reflecting delayed engraftment or persistent mixed chimerism (PMC). These conditions were associated with donor–recipient cytomegalovirus (CMV) serostatus and early CMV reactivation but not with immunosuppressive regimens or clinical outcome. qPCR predicted all 8/8 relapses with samples in the 6 months before onset by sustained positivity in both PB and BM compared with 1/8 relapses predicted by STR mainly in BM. The response kinetics to donor lymphocyte infusions for the treatment of PMC or relapse was shown by qPCR but not STR to be protracted over several months in 3 patients. Our results demonstrate the superior clinical utility of qPCR compared with STR for monitoring subtle changes of host chimerism associated with different clinical conditions, making a case for its use in the clinical follow-up of transplant patients." @default.
• W2623796402 created "2017-06-15" @default.
• W2623796402 creator A5001409916 @default.
• W2623796402 creator A5012385278 @default.
• W2623796402 creator A5027480329 @default.
• W2623796402 creator A5027599215 @default.
• W2623796402 creator A5041775689 @default.
• W2623796402 creator A5061913947 @default.
• W2623796402 creator A5077680007 @default.
• W2623796402 creator A5078150344 @default.
• W2623796402 creator A5078883445 @default.
• W2623796402 creator A5079883423 @default.
• W2623796402 creator A5081595462 @default.
• W2623796402 date "2017-10-01" @default.
• W2623796402 modified "2023-09-25" @default.
• W2623796402 title "Clinical Utility of Quantitative PCR for Chimerism and Engraftment Monitoring after Allogeneic Stem Cell Transplantation for Hematologic Malignancies" @default.
• W2623796402 cites W1493853131 @default.
• W2623796402 cites W1572602136 @default.
• W2623796402 cites W175852921 @default.
• W2623796402 cites W1873308820 @default.
• W2623796402 cites W1965141820 @default.
• W2623796402 cites W1969218349 @default.
• W2623796402 cites W1981449355 @default.
• W2623796402 cites W1991308016 @default.
• W2623796402 cites W1993168911 @default.
• W2623796402 cites W1996258788 @default.
• W2623796402 cites W2000653963 @default.
• W2623796402 cites W2003322468 @default.
• W2623796402 cites W2006714444 @default.
• W2623796402 cites W2009474598 @default.
• W2623796402 cites W2011208086 @default.
• W2623796402 cites W2014352019 @default.
• W2623796402 cites W2016791399 @default.
• W2623796402 cites W2021331728 @default.
• W2623796402 cites W2022956462 @default.
• W2623796402 cites W2025142706 @default.
• W2623796402 cites W2026927282 @default.
• W2623796402 cites W2027639308 @default.
• W2623796402 cites W2037711777 @default.
• W2623796402 cites W2042167238 @default.
• W2623796402 cites W2047031579 @default.
• W2623796402 cites W2049271851 @default.
• W2623796402 cites W2051260817 @default.
• W2623796402 cites W2058905748 @default.
• W2623796402 cites W2063299523 @default.
• W2623796402 cites W2064967925 @default.
• W2623796402 cites W2071145021 @default.
• W2623796402 cites W2074809365 @default.
• W2623796402 cites W2079888206 @default.
• W2623796402 cites W2085951767 @default.
• W2623796402 cites W2086585159 @default.
• W2623796402 cites W2089394867 @default.
• W2623796402 cites W2099166961 @default.
• W2623796402 cites W2107065200 @default.
• W2623796402 cites W2126494202 @default.
• W2623796402 cites W2142699023 @default.
• W2623796402 cites W2144737390 @default.
• W2623796402 cites W2152253814 @default.
• W2623796402 cites W2152515293 @default.
• W2623796402 cites W2160666689 @default.
• W2623796402 cites W2164059474 @default.
• W2623796402 cites W2167101066 @default.
• W2623796402 cites W2194972574 @default.
• W2623796402 cites W2284574660 @default.
• W2623796402 cites W2285753642 @default.
• W2623796402 cites W2330930577 @default.
• W2623796402 cites W2395266396 @default.
• W2623796402 cites W2493732290 @default.
• W2623796402 cites W2544424592 @default.
• W2623796402 cites W2556611242 @default.
• W2623796402 cites W2558062626 @default.
• W2623796402 cites W2733129701 @default.
• W2623796402 cites W4211214417 @default.
• W2623796402 cites W4235834002 @default.
• W2623796402 cites W42774651 @default.
• W2623796402 doi "https://doi.org/10.1016/j.bbmt.2017.05.031" @default.
• W2623796402 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28603070" @default.
• W2623796402 hasPublicationYear "2017" @default.
• W2623796402 type Work @default.
• W2623796402 sameAs 2623796402 @default.
• W2623796402 citedByCount "34" @default.
• W2623796402 countsByYear W26237964022017 @default.
• W2623796402 countsByYear W26237964022018 @default.
• W2623796402 countsByYear W26237964022019 @default.
• W2623796402 countsByYear W26237964022020 @default.
• W2623796402 countsByYear W26237964022021 @default.
• W2623796402 countsByYear W26237964022022 @default.
• W2623796402 countsByYear W26237964022023 @default.
• W2623796402 crossrefType "journal-article" @default.
• W2623796402 hasAuthorship W2623796402A5001409916 @default.
• W2623796402 hasAuthorship W2623796402A5012385278 @default.
• W2623796402 hasAuthorship W2623796402A5027480329 @default.
• W2623796402 hasAuthorship W2623796402A5027599215 @default.
• W2623796402 hasAuthorship W2623796402A5041775689 @default.
• W2623796402 hasAuthorship W2623796402A5061913947 @default.
• W2623796402 hasAuthorship W2623796402A5077680007 @default.
• W2623796402 hasAuthorship W2623796402A5078150344 @default.
• W2623796402 hasAuthorship W2623796402A5078883445 @default.

• next