Matches in SemOpenAlex for { <https://semopenalex.org/work/W2624092862> ?p ?o ?g. }
Showing items 1 to 83 of
83
with 100 items per page.
- W2624092862 endingPage "11" @default.
- W2624092862 startingPage "3" @default.
- W2624092862 abstract "Despite significant therapeutic advances, patients with chronic heart failure and reduced ejection fraction (HFrEF) remain at high risk for heart failure progression and death. The PARADIGM-HF study, the largest outcome trial in HFrEF, has shown improved cardiovascular outcomes with sacubitril/valsartan (Entresto®, Novartis), previously known as LCZ696, compared with angiotensin-converting enzyme (ACE) inhibitor therapy, possibly leading us to a new era for heart failure treatment. Sacubitril/valsartan represents a first-in-class drug acting through inhibition of angiotensin receptor and neprilysin, thus modulating the renin-angiotensin-aldosterone system and vasoactive substances such as natriuretic peptides. This approach can be considered a paradigm shift from neurohumoral inhibition to neurohumoral modulation. Based on the PARADIGM-HF results, the European Society of Cardiology and the American Heart Association/American College of Cardiology guidelines proposed a substitution of ACE-inhibitor/angiotensin receptor blocker therapy rather than an add-on strategy in HFrEF. Sacubitril/valsartan can be considered a milestone in cardiovascular therapy, like aspirin, statins, beta-blockers. Of course there are many questions that arise spontaneously from this trial, three recognized experts can help us to answer them." @default.
- W2624092862 created "2017-06-15" @default.
- W2624092862 creator A5024386124 @default.
- W2624092862 creator A5042687061 @default.
- W2624092862 creator A5060241741 @default.
- W2624092862 creator A5074415719 @default.
- W2624092862 date "2017-01-01" @default.
- W2624092862 modified "2023-09-24" @default.
- W2624092862 title "[Sacubitril/valsartan, a new and effective treatment for heart failure with reduced ejection fraction]." @default.
- W2624092862 doi "https://doi.org/10.1714/2654.27228" @default.
- W2624092862 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28492561" @default.
- W2624092862 hasPublicationYear "2017" @default.
- W2624092862 type Work @default.
- W2624092862 sameAs 2624092862 @default.
- W2624092862 citedByCount "2" @default.
- W2624092862 countsByYear W26240928622021 @default.
- W2624092862 countsByYear W26240928622022 @default.
- W2624092862 crossrefType "journal-article" @default.
- W2624092862 hasAuthorship W2624092862A5024386124 @default.
- W2624092862 hasAuthorship W2624092862A5042687061 @default.
- W2624092862 hasAuthorship W2624092862A5060241741 @default.
- W2624092862 hasAuthorship W2624092862A5074415719 @default.
- W2624092862 hasConcept C104826730 @default.
- W2624092862 hasConcept C104849204 @default.
- W2624092862 hasConcept C126322002 @default.
- W2624092862 hasConcept C164705383 @default.
- W2624092862 hasConcept C181199279 @default.
- W2624092862 hasConcept C185592680 @default.
- W2624092862 hasConcept C2775999527 @default.
- W2624092862 hasConcept C2776754050 @default.
- W2624092862 hasConcept C2777387769 @default.
- W2624092862 hasConcept C2778198053 @default.
- W2624092862 hasConcept C2908929049 @default.
- W2624092862 hasConcept C55493867 @default.
- W2624092862 hasConcept C71924100 @default.
- W2624092862 hasConcept C78085059 @default.
- W2624092862 hasConcept C84393581 @default.
- W2624092862 hasConceptScore W2624092862C104826730 @default.
- W2624092862 hasConceptScore W2624092862C104849204 @default.
- W2624092862 hasConceptScore W2624092862C126322002 @default.
- W2624092862 hasConceptScore W2624092862C164705383 @default.
- W2624092862 hasConceptScore W2624092862C181199279 @default.
- W2624092862 hasConceptScore W2624092862C185592680 @default.
- W2624092862 hasConceptScore W2624092862C2775999527 @default.
- W2624092862 hasConceptScore W2624092862C2776754050 @default.
- W2624092862 hasConceptScore W2624092862C2777387769 @default.
- W2624092862 hasConceptScore W2624092862C2778198053 @default.
- W2624092862 hasConceptScore W2624092862C2908929049 @default.
- W2624092862 hasConceptScore W2624092862C55493867 @default.
- W2624092862 hasConceptScore W2624092862C71924100 @default.
- W2624092862 hasConceptScore W2624092862C78085059 @default.
- W2624092862 hasConceptScore W2624092862C84393581 @default.
- W2624092862 hasIssue "1" @default.
- W2624092862 hasLocation W26240928621 @default.
- W2624092862 hasOpenAccess W2624092862 @default.
- W2624092862 hasPrimaryLocation W26240928621 @default.
- W2624092862 hasRelatedWork W2130271234 @default.
- W2624092862 hasRelatedWork W2186484749 @default.
- W2624092862 hasRelatedWork W2188130254 @default.
- W2624092862 hasRelatedWork W2246391228 @default.
- W2624092862 hasRelatedWork W2267226196 @default.
- W2624092862 hasRelatedWork W2337127286 @default.
- W2624092862 hasRelatedWork W2507866328 @default.
- W2624092862 hasRelatedWork W2591831185 @default.
- W2624092862 hasRelatedWork W2763343438 @default.
- W2624092862 hasRelatedWork W2790865467 @default.
- W2624092862 hasRelatedWork W2791543777 @default.
- W2624092862 hasRelatedWork W2805439296 @default.
- W2624092862 hasRelatedWork W2810662961 @default.
- W2624092862 hasRelatedWork W2890128092 @default.
- W2624092862 hasRelatedWork W2945205947 @default.
- W2624092862 hasRelatedWork W2969849159 @default.
- W2624092862 hasRelatedWork W2989920874 @default.
- W2624092862 hasRelatedWork W3045615865 @default.
- W2624092862 hasRelatedWork W3080996083 @default.
- W2624092862 hasRelatedWork W2604870649 @default.
- W2624092862 hasVolume "18" @default.
- W2624092862 isParatext "false" @default.
- W2624092862 isRetracted "false" @default.
- W2624092862 magId "2624092862" @default.
- W2624092862 workType "article" @default.