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• W2624288510 endingPage "1321347" @default.
• W2624288510 startingPage "1321347" @default.
• W2624288510 abstract "Background : Enteroendocrine cells respond to food components by secreting an array of hormones that regulate several functions. We have previously shown that grape seed proanthocyanidins (GSPE) modulate GLP-1 levels. Objective : To deepen on the knowledge of the mechanisms used by GSPE to increase GLP-1, and extend it to its role at modulation of other enterohormones. Design : We used an ex vivo system to test direct modulation of enterohormones; STC-1 cells to test pure phenolic compounds; and rats to test the effects at different gastrointestinal segments. Results : GSPE compounds act at several locations along the gastrointestinal tract modulating enterohormone secretion depending on the feeding condition. GSPE directly promotes GLP-1 secretion in the ileum, while unabsorbed/metabolized forms do so in the colon. Such stimulation requires the presence of glucose. GSPE enhanced GIP and reduced CCK secretion; gallic acid could be partly responsible for this effect. Conclusions : The activity of GSPE modulating enterohormone secretion may help to explain its effects on metabolism. GSPE acts through several mechanisms; its compounds and their metabolites are GLP-1 secretagogues in ileum and colon, respectively. In vivo GLP-1 secretion might also be mediated by indirect pathways involving modulation of other enterohormones that in turn regulate GLP-1 release." @default.
• W2624288510 created "2017-06-15" @default.
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• W2624288510 date "2017-01-01" @default.
• W2624288510 modified "2023-09-27" @default.
• W2624288510 title "Acute selective bioactivity of grape seed proanthocyanidins on enteroendocrine secretions in the gastrointestinal tract" @default.
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• W2624288510 doi "https://doi.org/10.1080/16546628.2017.1321347" @default.
• W2624288510 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5475339" @default.
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