FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2624331415> ?p ?o ?g. }

• W2624331415 endingPage "115" @default.
• W2624331415 startingPage "107" @default.
• W2624331415 abstract "Non-surgical bleeding (NSB) due to angiodysplasia is common in left ventricular assist device (LVAD) patients. Thrombin-induced angiopoietin-2 (Ang-2) expression in LVAD patients leads to altered angiogenesis and is associated with lower angiopoietin-1 (Ang-1) and increased NSB. However, the mechanism for decreased Ang-1, made by pericytes, is unknown and the origin of thrombin in LVAD patients is unclear. We hypothesized that high tumor necrosis factor-α (TNF-α) levels in LVAD patients induce pericyte apoptosis, tissue factor (TF) expression and vascular instability.We incubated cultured pericytes with serum from patients with heart failure (HF), LVAD or orthotopic heart transplantation (OHT), with or without TNF-α blockade. We performed several measurements: Ang-1 expression was assessed by reverse transcript-polymerase chain reaction (RT-PCR) and pericyte death fluorescently; TF expression was assessed by RT-PCR in cultured endothelial cells incubated with patient plasma with or without TNF-α blockade; and TF expression was assessed in endothelial biopsy samples from these patients by immunofluorescence. We incubated cultured endothelial cells on Matrigel with patient serum with or without TNF-α blockade and determined tube formation by microscopy.Serum from LVAD patients had higher levels of TNF-α, suppressed Ang-1 expression in pericytes, and induced pericyte death, and there was accelerated endothelial tube formation compared with serum from patients without LVADs. TF was higher in both plasma and endothelial cells from LVAD patients, and plasma from LVAD patients induced more endothelial TF expression. All of these effects were reversed or reduced with TNF-α blockade. High levels of TNF-α were associated with increased risk of NSB.Elevated TNF-α in LVAD patients is a central regulator of altered angiogenesis, pericyte apoptosis and expression of TF and Ang-1." @default.
• W2624331415 created "2017-06-15" @default.
• W2624331415 creator A5002461650 @default.
• W2624331415 creator A5010397554 @default.
• W2624331415 creator A5017305767 @default.
• W2624331415 creator A5044672059 @default.
• W2624331415 creator A5059165810 @default.
• W2624331415 creator A5064491810 @default.
• W2624331415 date "2018-01-01" @default.
• W2624331415 modified "2023-10-10" @default.
• W2624331415 title "Tumor necrosis factor-α levels and non-surgical bleeding in continuous-flow left ventricular assist devices" @default.
• W2624331415 cites W1274671738 @default.
• W2624331415 cites W1873126901 @default.
• W2624331415 cites W193610742 @default.
• W2624331415 cites W1964611695 @default.
• W2624331415 cites W1978082123 @default.
• W2624331415 cites W2000502243 @default.
• W2624331415 cites W2006122359 @default.
• W2624331415 cites W2007915697 @default.
• W2624331415 cites W2015436684 @default.
• W2624331415 cites W2016068982 @default.
• W2624331415 cites W2029337398 @default.
• W2624331415 cites W2035144483 @default.
• W2624331415 cites W2038831639 @default.
• W2624331415 cites W2054919355 @default.
• W2624331415 cites W2057205964 @default.
• W2624331415 cites W2058599028 @default.
• W2624331415 cites W2061047184 @default.
• W2624331415 cites W2069200731 @default.
• W2624331415 cites W2072807615 @default.
• W2624331415 cites W2074710857 @default.
• W2624331415 cites W2075122399 @default.
• W2624331415 cites W2077385734 @default.
• W2624331415 cites W2081971657 @default.
• W2624331415 cites W2082897182 @default.
• W2624331415 cites W2088975327 @default.
• W2624331415 cites W2089750661 @default.
• W2624331415 cites W2092050476 @default.
• W2624331415 cites W2094032463 @default.
• W2624331415 cites W2097255540 @default.
• W2624331415 cites W2098533150 @default.
• W2624331415 cites W2099122266 @default.
• W2624331415 cites W2107425890 @default.
• W2624331415 cites W2109339951 @default.
• W2624331415 cites W2110619084 @default.
• W2624331415 cites W2115390024 @default.
• W2624331415 cites W2115533377 @default.
• W2624331415 cites W2116632271 @default.
• W2624331415 cites W2118820973 @default.
• W2624331415 cites W2119859302 @default.
• W2624331415 cites W2121626542 @default.
• W2624331415 cites W2124732705 @default.
• W2624331415 cites W2145557434 @default.
• W2624331415 cites W2146826066 @default.
• W2624331415 cites W2152013285 @default.
• W2624331415 cites W2160870679 @default.
• W2624331415 cites W2164122959 @default.
• W2624331415 cites W2166889065 @default.
• W2624331415 cites W2168257249 @default.
• W2624331415 cites W2186734062 @default.
• W2624331415 cites W2192722393 @default.
• W2624331415 cites W2320842641 @default.
• W2624331415 cites W2329296588 @default.
• W2624331415 cites W2410958869 @default.
• W2624331415 cites W2497397127 @default.
• W2624331415 cites W2538318178 @default.
• W2624331415 cites W2545459086 @default.
• W2624331415 cites W1972640825 @default.
• W2624331415 cites W2033699167 @default.
• W2624331415 cites W2054925281 @default.
• W2624331415 doi "https://doi.org/10.1016/j.healun.2017.06.001" @default.
• W2624331415 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5722712" @default.
• W2624331415 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28651907" @default.
• W2624331415 hasPublicationYear "2018" @default.
• W2624331415 type Work @default.
• W2624331415 sameAs 2624331415 @default.
• W2624331415 citedByCount "47" @default.
• W2624331415 countsByYear W26243314152018 @default.
• W2624331415 countsByYear W26243314152019 @default.
• W2624331415 countsByYear W26243314152020 @default.
• W2624331415 countsByYear W26243314152021 @default.
• W2624331415 countsByYear W26243314152022 @default.
• W2624331415 countsByYear W26243314152023 @default.
• W2624331415 crossrefType "journal-article" @default.
• W2624331415 hasAuthorship W2624331415A5002461650 @default.
• W2624331415 hasAuthorship W2624331415A5010397554 @default.
• W2624331415 hasAuthorship W2624331415A5017305767 @default.
• W2624331415 hasAuthorship W2624331415A5044672059 @default.
• W2624331415 hasAuthorship W2624331415A5059165810 @default.
• W2624331415 hasAuthorship W2624331415A5064491810 @default.
• W2624331415 hasBestOaLocation W26243314152 @default.
• W2624331415 hasConcept C123012128 @default.
• W2624331415 hasConcept C126322002 @default.
• W2624331415 hasConcept C134018914 @default.
• W2624331415 hasConcept C142724271 @default.
• W2624331415 hasConcept C164705383 @default.
• W2624331415 hasConcept C167734588 @default.
• W2624331415 hasConcept C170493617 @default.

• next